Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors Fulltext Access 4 Pages 2007
Synthesis and biological evaluation of 7-azaindole derivatives, synthetic cytokinin analogues Fulltext Access 4 Pages 2007
Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity Fulltext Access 4 Pages 2007
Self-aggregation of zinc chlorophylls possessing perfluoroalkyl chains in fluorous solvents: Selective extraction of the self-aggregates with fluorous phase and accelerated formation of the ordered supramolecules in this phase Fulltext Access 4 Pages 2007
A long-acting selective neuropeptide Y2 receptor PEGylated peptide agonist reduces food intake in mice Fulltext Access 4 Pages 2007
Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold Fulltext Access 4 Pages 2007
N-Hydroxythiosemicarbazones: Synthesis and in vitro antitubercular activity Fulltext Access 4 Pages 2007
Neuroprotective effects of kobophenol A against the withdrawal of tropic support, nitrosative stress, and mitochondrial damage in SH-SY5Y neuroblastoma cells Fulltext Access 4 Pages 2007
Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: Structural recognition of STAT SH2 domains Fulltext Access 4 Pages 2007
Polypseudorotaxanes of pegylated insulin with cyclodextrins: Application to sustained release system Fulltext Access 4 Pages 2007
3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists Fulltext Access 4 Pages 2007
Synthesis of furanosyl α-C-glycosides derived from 4-chloro-4-deoxy-α-d-galactose and their cytotoxic activities Fulltext Access 4 Pages 2007
Thyroid receptor ligands. Part 7: Indirect antagonists of the thyroid hormone receptor with improved affinity Fulltext Access 4 Pages 2007
Synthesis and biological activity of naphthalene analogues of phenstatins: Naphthylphenstatins Fulltext Access 4 Pages 2007
A cell-permeable inhibitor and activity-based probe for the caspase-like activity of the proteasome Fulltext Access 4 Pages 2007
Synthesis and evaluation of 2′-substituted cyclobutyl nucleosides and nucleotides as potential anti-HIV agents Fulltext Access 4 Pages 2007
Discovery of 1-(4-phenoxypiperidin-1-yl)-2-arylaminoethanone stearoyl-CoA desaturase 1 inhibitors Fulltext Access 4 Pages 2007
Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin Fulltext Access 4 Pages 2007
Benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides as inhibitors of carbonic anhydrase Fulltext Access 4 Pages 2007
Discovery and SAR development of thienopyridones: A class of small molecule AMPK activators Fulltext Access 4 Pages 2007
Synthesis and antibacterial activity of some novel chiral fluorophoric biscyclic macrocycles Fulltext Access 4 Pages 2007
Development of new pyrrolopyrimidine-based inhibitors of Janus kinase 3 (JAK3) Fulltext Access 4 Pages 2007
Novel membrane-localizing TEMPO derivatives for measurement of cellular oxidative stress at the cell membrane Fulltext Access 4 Pages 2007
N-Alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) prodrugs of carboxylic acid containing drugs Fulltext Access 4 Pages 2007
4-[6-(2-Aminoethyl)naphthalen-2-yl]benzonitriles are potent histamine H3 receptor antagonists with high CNS penetration Fulltext Access 4 Pages 2007
Ac2-DPD, the bis-(O)-acetylated derivative of 4,5-dihydroxy-2,3-pentanedione (DPD) is a convenient stable precursor of bacterial quorum sensing autoinducer AI-2 Fulltext Access 4 Pages 2007
Synthesis and evaluation of novel chromogenic aminopeptidase substrates for microorganism detection and identification Fulltext Access 4 Pages 2007
Dopamine/serotonin receptor ligands. Part 15: Oxygenation of the benz-indolo-azecine LE 300 leads to novel subnanomolar dopamine D1/D5 antagonists Fulltext Access 4 Pages 2007
Inhibition of Src kinase activity by 7-ethynyl-4-phenylamino-3-quinolinecarbonitriles: Identification of SKS-927 Fulltext Access 4 Pages 2007
Novel antiproliferative analogs of the Taq DNA polymerase inhibitor catalpol Fulltext Access 4 Pages 2007
3-Hydroxychromones as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation Fulltext Access 4 Pages 2007
High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity Fulltext Access 4 Pages 2007
A novel diketo phosphonic acid that exhibits specific, strand-transfer inhibition of HIV integrase and anti-HIV activity Fulltext Access 4 Pages 2007
Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents Fulltext Access 4 Pages 2007
5-((1H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5 Fulltext Access 4 Pages 2007
Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2) Fulltext Access 4 Pages 2007
Synthesis and antibacterial evaluation of a novel series of rifabutin-like spirorifamycins Fulltext Access 4 Pages 2007
A new visual screening assay for catalytic antibodies with retro-aldol retro-Michael activity Fulltext Access 4 Pages 2007
Synthesis of new xanthone analogues and their biological activity test—Cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study Fulltext Access 4 Pages 2007
Novel mitochondria-localizing TEMPO derivative for measurement of cellular oxidative stress in mitochondria Fulltext Access 4 Pages 2007
Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide Fulltext Access 4 Pages 2007
N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors Fulltext Access 4 Pages 2007
Preparation, characterization and in vivo conversion of new water-soluble sulfenamide prodrugs of carbamazepine Fulltext Access 4 Pages 2007
Synthesis and reactivity of azobenzene-based bispropargyl sulfones: Interesting comparison between cyclic and acyclic systems Fulltext Access 4 Pages 2007
Proinsecticide candidates N-(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl derivatives of imidacloprid and 1-chlorothiazolylmethyl-2-nitroimino-imidazolidine Fulltext Access 4 Pages 2007
Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition Fulltext Access 4 Pages 2007
Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators Fulltext Access 4 Pages 2007
Gypsophin: A novel α-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana Fulltext Access 4 Pages 2007
Design, synthesis, and molecular modeling studies of 5′-deoxy-5′-ureidoadenosine: 5′-ureido group as multiple hydrogen bonding donor in the active site of S-adenosylhomocysteine hydrolase Fulltext Access 4 Pages 2007
Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol Fulltext Access 4 Pages 2007
Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists Fulltext Access 4 Pages 2007
Efficient synthesis and in vitro cytostatic activity of 4-substituted triazolyl-nucleosides Fulltext Access 4 Pages 2007
Synthesis and cytotoxic activity of various 5-[alkoxy-(4-nitro-phenyl)-methyl]-uracils in their racemic form Fulltext Access 4 Pages 2007
Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy Fulltext Access 4 Pages 2007
Synthesis and antibacterial activity of novel fluoroquinolones containing substituted piperidines Fulltext Access 4 Pages 2007
3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b Fulltext Access 4 Pages 2007
Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification Fulltext Access 4 Pages 2007
Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists Fulltext Access 4 Pages 2007
Dipeptidyl α-fluorovinyl Michael acceptors: Synthesis and activity against cysteine proteases Fulltext Access 4 Pages 2007
Preparation of carbohydrate–oligonucleotide conjugates using the squarate spacer Fulltext Access 4 Pages 2007
Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists Fulltext Access 4 Pages 2007
Identifying common metalloprotease inhibitors by protein fold types using Fourier Transform Mass Spectrometry Fulltext Access 4 Pages 2007
Phenylpiperidine-benzoxazinones as urotensin-II receptor antagonists: Synthesis, SAR, and in vivo assessment Fulltext Access 4 Pages 2007
Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors Fulltext Access 4 Pages 2007
Synthesis and structure–activity relationships of second-generation hydroxamate botulinum neurotoxin A protease inhibitors Fulltext Access 4 Pages 2007
Benzopyrans as selective estrogen receptor β agonists (SERBAs). Part 4: Functionalization of the benzopyran A-ring Fulltext Access 4 Pages 2007
Novel substituted tetrahydrotriazaacenaphthylene derivatives as potent CRF1 receptor antagonists Fulltext Access 4 Pages 2007
Studies on a series of potent, orally bioavailable, 5-HT1 receptor ligands Fulltext Access 4 Pages 2007
Synthesis, resolution, and antiplatelet activity of 3-substituted 1(3H)-isobenzofuranone Fulltext Access 4 Pages 2007
A minimalistic approach to identify substrate binding features in B1 Metallo-β-lactamases Fulltext Access 4 Pages 2007
Optimized synthesis of aminooxy-peptides as glycoprobe precursors for surface-based sugar–protein interaction studies Fulltext Access 4 Pages 2007
Development of oligoarginine–drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption Fulltext Access 4 Pages 2007
Synthesis of fluorescent and photoaffinity-labeled derivatives of bisphenol A and their inhibitory activity toward hypoxic expression of erythropoietin Fulltext Access 4 Pages 2007
Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: Further optimization of anti-hepatitis C virus activity Fulltext Access 4 Pages 2007
Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells Fulltext Access 4 Pages 2007
An atom efficient, solvent-free, green synthesis and antimycobacterial evaluation of 2-amino-6-methyl-4-aryl-8-[(E)-arylmethylidene]-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridine-3-carbonitriles Fulltext Access 4 Pages 2007
Unique spirocyclopiperazinium salt. Part 4: Modification of dispirocyclopiperazinium (DSPZ) salts as analgesics Fulltext Access 4 Pages 2007
Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation Fulltext Access 4 Pages 2007
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety Fulltext Access 4 Pages 2007
Synthesis and SAR of novel conformationally restricted oxazolidinones possessing Gram-positive and fastidious Gram-negative antibacterial activity. Part 2: Amino substitutions on heterocyclic D-ring system Fulltext Access 4 Pages 2007
Selective oxidation of sulfides to sulfoxides catalyzed by ruthenium (III) meso-tetraphenylporphyrin chloride in the presence of molecular oxygen Fulltext Access 4 Pages 2007
Human serum albumin binding assay based on displacement of a non selective fluorescent inhibitor Fulltext Access 4 Pages 2007
Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis Fulltext Access 4 Pages 2007
Design, synthesis, and preliminary biological evaluation of a novel triazole analogue of ceramide Fulltext Access 4 Pages 2007
Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis Fulltext Access 4 Pages 2007