Antiproliferative activity of 4-chloro-5,6-dihydro-2H-pyrans. Part 2: Enhancement of drug cytotoxicity Fulltext Access 4 Pages 2007
Synthesis of new plant growth regulator: N-(Fatty acid) O-aryloxyacetyl ethanolamine Fulltext Access 4 Pages 2007
Evaluation of nitrate-substituted pseudocholine esters of aspirin as potential nitro-aspirins Fulltext Access 4 Pages 2007
Synthesis, biological evaluations, and tubulin binding poses of C-2α sulfur linked taxol analogues Fulltext Access 4 Pages 2007
Formation of an enolate intermediate is required for the reaction catalyzed by 3-hydroxyacyl-CoA dehydrogenase Fulltext Access 4 Pages 2007
4-Substituted indazoles as new inhibitors of neuronal nitric oxide synthase Fulltext Access 4 Pages 2007
Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor Fulltext Access 4 Pages 2007
Preparation of novel anthranilic acids as antibacterial agents: Extensive evaluation of structural and physical properties on antibacterial activity and human serum albumin affinity Fulltext Access 4 Pages 2007
Piperazinyl CCR1 antagonists—optimization of human liver microsome stability Fulltext Access 4 Pages 2007
Enzymatic synthesis of arbutin undecylenic acid ester and its inhibitory effect on melanin synthesis Fulltext Access 4 Pages 2007
Concise synthesis of dideoxy-epigallocatechin gallate (DO-EGCG) and evaluation of its anti-influenza virus activity Fulltext Access 4 Pages 2007
Glaziovianin A, a new isoflavone, from the leaves of Ateleia glazioviana and its cytotoxic activity against human cancer cells Fulltext Access 4 Pages 2007
Antiproliferative activity of 2-alkyl-4-halopiperidines and 2-alkyl-4-halo-1,2,5,6-tetrahydropyridines in solid tumor cell lines Fulltext Access 4 Pages 2007
Dual M3 antagonists-PDE4 inhibitors. Part 2: Synthesis and SAR of 3-substituted azetidinyl derivatives Fulltext Access 4 Pages 2007
Synthesis and biological evaluation of 2β,3α-(substituted phenyl)nortropanes as potential norepinephrine transporter imaging agents Fulltext Access 4 Pages 2007
The thioesterase domain from the pimaricin and erythromycin biosynthetic pathways can catalyze hydrolysis of simple thioester substrates Fulltext Access 4 Pages 2007
Synthesis and antitubercular activity of phenothiazines with reduced binding to dopamine and serotonin receptors Fulltext Access 4 Pages 2007
Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as γ-secretase inhibitors Fulltext Access 4 Pages 2007
Potent bradykinin B1 receptor antagonists: 4-Substituted phenyl cyclohexanes Fulltext Access 4 Pages 2007
Design, synthesis, and antitumor activity of bile acid–polyamine–nucleoside conjugates Fulltext Access 4 Pages 2007
Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis Fulltext Access 4 Pages 2007
Amyloid-forming propensity of the hydrophobic non-natural amino acid on the fibril-forming core peptide of human tau Fulltext Access 4 Pages 2007
Ortho-azo substituted phenylboronic acids for colorimetric sugar sensors Fulltext Access 4 Pages 2007
Synthesis of fluorescent-labeled aeruginosin derivatives for high-throughput fluorescence correlation spectroscopy assays Fulltext Access 4 Pages 2007
A glycosylated complex of gadolinium, a new potential contrast agent for magnetic resonance angiography? Fulltext Access 4 Pages 2007
Synthesis and biological evaluation of two glycerolipidic prodrugs of didanosine for direct lymphatic delivery against HIV Fulltext Access 4 Pages 2007
Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers Fulltext Access 4 Pages 2007
Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B Fulltext Access 4 Pages 2007
Structure-activity relationship studies on anti-HCV activity of ring-expanded ('fat') nucleobase analogues containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system Fulltext Access 4 Pages 2007
Structural requirements of HDAC inhibitors: SAHA analogs functionalized adjacent to the hydroxamic acid Fulltext Access 4 Pages 2007
Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists Fulltext Access 4 Pages 2007
Synthesis and in vitro cytotoxicity of novel lipophilic (diamine)platinum(II) complexes of salicylate derivatives Fulltext Access 4 Pages 2007
Novel 3-galloylamido-N′-substituted-2,6-piperidinedione-N-acetamide peptidomimetics as metalloproteinase inhibitors Fulltext Access 4 Pages 2007
Sulfonamide-related conformational effects and their importance in structure-based design Fulltext Access 4 Pages 2007
Selective and dual action orally active inhibitors of thrombin and factor Xa Fulltext Access 4 Pages 2007
The crystal structures of copper(II), manganese(II), and nickel(II) complexes of a (Z)-2-hydroxy-N′-(2-oxoindolin-3-ylidene) benzohydrazide—potential antitumor agents Fulltext Access 4 Pages 2007
Analogs of the marine alkaloid makaluvamines: Synthesis, topoisomerase II inhibition, and anticancer activity Fulltext Access 4 Pages 2007
Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors Fulltext Access 4 Pages 2007
Synthesis of enantiomerically pure milnacipran analogs and inhibition of dopamine, serotonin, and norepinephrine transporters Fulltext Access 4 Pages 2007
Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokine induction and the discovery of non-linear phytosphingosine analogs Fulltext Access 4 Pages 2007
Probing length effects and mechanism of cell penetrating agents mounted on a polyproline helix scaffold Fulltext Access 4 Pages 2007
Cobaltpolyoxometalate-catalyzed cyclization of glucal with aryl amines: Synthesis of 2,4-disubstituted tetrahydroquinolines Fulltext Access 4 Pages 2007
DNA cleavage promoted by 2,9-dimethyl-4,7-diazadecane-2,9-dithiol (DDD) derivatives Fulltext Access 4 Pages 2007
SAR studies on thiazolo[4,5-d]pyrimidine based CXCR2 antagonists involving a novel tandem displacement reaction Fulltext Access 4 Pages 2007
Sulfenamides as prodrugs of NH-acidic compounds: A new prodrug option for the amide bond Fulltext Access 4 Pages 2007
Potent macrocyclic antagonists to the motilin receptor presenting novel unnatural amino acids Fulltext Access 4 Pages 2007
Synthesis and in vitro protozoocidal activity of diazabicyclic benzotropolone derivatives Fulltext Access 4 Pages 2007
Design, synthesis, and biological activity of novel triazole amino acids used to probe binding interactions between ligand and neutral amino acid transport protein SN1 Fulltext Access 4 Pages 2007
(2R,3S)-(+)- and (2S,3R)-(−)-Halofuginone lactate: Synthesis, absolute configuration, and activity against Cryptosporidium parvum Fulltext Access 4 Pages 2007
Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-α-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141 Fulltext Access 4 Pages 2007
Discovery of 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7-phenyl-(E)-2,3,6,7-tetrahydro-1,4-thiazepines as a new series of apoptosis inducers using a cell- and caspase-based HTS assay Fulltext Access 4 Pages 2007
Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1 Fulltext Access 4 Pages 2007
Interaction of O-(undec-10-en)-yl-d-glucose derivatives with the Plasmodium falciparum hexose transporter (PfHT) Fulltext Access 4 Pages 2007
Synthesis and evaluation of α,β-unsaturated α-aryl-substituted fosmidomycin analogues as DXR inhibitors Fulltext Access 4 Pages 2007
Synthesis, determination of stereochemistry, and evaluation of new bisindole alkaloids from the myxomycete Arcyria ferruginea: An approach for Wnt signal inhibitor Fulltext Access 4 Pages 2007
New triterpene glucosides, oligoporins A–C, from Oligoporus tephroleucus protect DNA from Fenton reaction Fulltext Access 4 Pages 2007
A relationship between amide hydrogen bond strength and quinone reduction potential: Implications for photosystem I and bacterial reaction center quinone function Fulltext Access 4 Pages 2007
Quinazoline derivatives as MC-I inhibitors: Evaluation of myocardial uptake using Positron Emission Tomography in rat and non-human primate Fulltext Access 4 Pages 2007
Metabolically labile cannabinoid esters: A ‘soft drug’ approach for the development of cannabinoid-based therapeutic drugs Fulltext Access 4 Pages 2007
Synthesis and anti-influenza activities of carboxyl alkoxyalkyl esters of 4-guanidino-Neu5Ac2en (zanamivir) Fulltext Access 4 Pages 2007
α,α-Cyclic aminoacids as useful scaffolds for the preparation of hNK2 receptor antagonists Fulltext Access 4 Pages 2007
Oxazolones as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 Fulltext Access 4 Pages 2007
Synthesis and structure–activity relationship of RXR antagonists based on the diazepinylbenzoic acid structure Fulltext Access 4 Pages 2007
Synthesis and structure–activity relationship of novel RXR antagonists: Orally active anti-diabetic and anti-obesity agents Fulltext Access 4 Pages 2007
Caprolactams as potent CGRP receptor antagonists for the treatment of migraine Fulltext Access 4 Pages 2007
[1,2,3]Triazolo[4,5-h]quinolones. A new class of potent antitubercular agents against multidrug resistant Mycobacterium tuberculosis strains Fulltext Access 4 Pages 2007
Synthesis and SAR studies of potent imidazopyridine anticoccidial agents Fulltext Access 4 Pages 2007
Derivatives of oxoisoaporphine alkaloids: A novel class of selective acetylcholinesterase inhibitors Fulltext Access 4 Pages 2007
Phosphonic acid analogs of GABA through reductive dealkylation of phosphonic diesters with lithium trialkylborohydrides Fulltext Access 4 Pages 2007
Synthesis and biological evaluation of analogues of the anti-tumor alkaloid naamidine A Fulltext Access 4 Pages 2007
Structure–activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors Fulltext Access 4 Pages 2007
Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: A pharmacophoric hybrid approach Fulltext Access 4 Pages 2007
Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov. Fulltext Access 4 Pages 2007
Synthesis and antifungal activities of new fluconazole analogues with azaheterocycle moiety Fulltext Access 4 Pages 2007
Improvement of base selectivity and binding affinity by controlling hydrogen bonding motifs between nucleobases and isoxanthopterin: Application to the detection of T/C mutation Fulltext Access 4 Pages 2007
Design, synthesis, and anti-HIV activity of 2′,3′-didehydro-2′,3′-dideoxyuridine (d4U), 2′,3′-dideoxyuridine (ddU) phosphoramidate ‘ProTide’ derivatives Fulltext Access 4 Pages 2007
Design, synthesis, and structure–activity relationship of carbamate-tethered aryl propanoic acids as novel PPARα/γ dual agonists Fulltext Access 4 Pages 2007
Radioiodinated aza-diphenylacetylenes as potential SPECT imaging agents for β-amyloid plaque detection Fulltext Access 4 Pages 2007
Synthesis and antibacterial activity of 5-deoxy-5-episubstituted arbekacin derivatives Fulltext Access 4 Pages 2007
Design, docking, and synthesis of novel indeno[1,2-c]isoquinolines for the development of antitumor agents as topoisomerase I inhibitors Fulltext Access 4 Pages 2007
SAR of a novel 'Anthranilamide Like' series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer Fulltext Access 4 Pages 2007
Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors Fulltext Access 4 Pages 2007
Antimicrobial activity of rationally designed amino terminal modified peptides Fulltext Access 4 Pages 2007
Anti-AIDS agents 72. Bioisosteres (7-carbon-DCKs) of the potent anti-HIV lead DCK Fulltext Access 4 Pages 2007
3D-QSAR studies on sildenafil analogues, selective phosphodiesterase 5 inhibitors Fulltext Access 4 Pages 2007
Aqua mediated synthesis of substituted 2-amino-4H-chromenes catalyzed by green and reusable Preyssler heteropolyacid Fulltext Access 4 Pages 2007