Structure–activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1 Fulltext Access 4 Pages 2007
Design, synthesis, and biological evaluation of tricyclic heterocycle-tetraamine conjugates as potent NMDA channel blockers Fulltext Access 4 Pages 2007
Correlation of carboxylic acid pKa to protein binding and antibacterial activity of a novel class of bacterial translation inhibitors Fulltext Access 4 Pages 2007
Conversion of the LXR-agonist TO-901317—From inverse to normal modulation of γ-secretase by addition of a carboxylic acid and a lipophilic anchor Fulltext Access 4 Pages 2007
Anti-tubercular agents. Part IV: Synthesis and antimycobacterial evaluation of nitroheterocyclic-based 1,2,4-benzothiadiazines Fulltext Access 4 Pages 2007
Cyclonatsudamine A, a new vasodilator cyclic peptide from Citrus natsudaidai Fulltext Access 4 Pages 2007
Pyrazolo[3,4-d]pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR) Fulltext Access 4 Pages 2007
Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists Fulltext Access 4 Pages 2007
Toward novel HIV-1 integrase binding inhibitors: Molecular modeling, synthesis, and biological studies Fulltext Access 4 Pages 2007
Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos Fulltext Access 4 Pages 2007
2-O-Carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity Fulltext Access 4 Pages 2007
Application of multicomponent reactions to antimalarial drug discovery. Part 3: Discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro Fulltext Access 4 Pages 2007
1,2,4-Benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: Synthesis, DNA-binding affinity and cytotoxicity Fulltext Access 4 Pages 2007
Carbocyclic 3′-deoxyadenosine-based highly potent bisubstrate-analog inhibitor of basophilic protein kinases Fulltext Access 4 Pages 2007
Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety Fulltext Access 4 Pages 2007
Melanocortin subtype 4 receptor agonists: Structure–activity relationships about the 4-alkyl piperidine core Fulltext Access 4 Pages 2007
Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3β Fulltext Access 4 Pages 2007
Synthesis and antitubercular activity of lipophilic moxifloxacin and gatifloxacin derivatives Fulltext Access 4 Pages 2007
Novel anti-infection agents: Small-molecule inhibitors of bacterial transcription factors Fulltext Access 4 Pages 2007
Synthesis and biological evaluation of a C5-biphenyl thiolactomycin library Fulltext Access 4 Pages 2007
Synthesis of 2,3-diaryl-1,3-thiazolidine-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors Fulltext Access 4 Pages 2007
5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2) Fulltext Access 4 Pages 2007
Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a Fulltext Access 4 Pages 2007
The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase Fulltext Access 4 Pages 2007
Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I Fulltext Access 4 Pages 2007
[(S)-γ-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors Fulltext Access 4 Pages 2007
[d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor Fulltext Access 4 Pages 2007
Synthesis and in vitro evaluation of tetrahydroisoquinolinyl benzamides as ligands for σ receptors Fulltext Access 4 Pages 2007
Synthesis and evaluation of a novel lipid–peptide conjugate for functionalized liposome Fulltext Access 4 Pages 2007
Synthesis and antifungal activity of 6-arylamino-phthalazine-5,8-diones and 6,7-bis(arylthio)-phthalazine-5,8-diones Fulltext Access 4 Pages 2007
Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors Fulltext Access 4 Pages 2007
Synthesis and characterisation of a new pH-sensitive amphotericin B—poly(ethylene glycol)-b-poly(l-lysine) conjugate Fulltext Access 4 Pages 2007
β-Alkylthio indolyl carbinols: Potent nonsteroidal antiandrogens with oral efficacy in a prostate cancer model Fulltext Access 4 Pages 2007
Parallel synthesis and SAR study of novel oxa-steroids as potent and selective progesterone receptor antagonists Fulltext Access 4 Pages 2007
Novel 1,4-benzodiazepine derivatives with antiproliferative properties on tumor cell lines Fulltext Access 4 Pages 2007
1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors Fulltext Access 4 Pages 2007
Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor Fulltext Access 4 Pages 2007
Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. Fulltext Access 4 Pages 2007
Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents Fulltext Access 4 Pages 2007
Cyclic monophosphate prodrugs of base-modified 2′-C-methyl ribonucleosides as potent inhibitors of hepatitis C virus RNA replication Fulltext Access 4 Pages 2007
N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors Fulltext Access 4 Pages 2007
ABC synthesis and antitumor activity of a series of Annonaceous acetogenin analogs with a threo, trans, threo, trans, threo-bis-tetrahydrofuran core unit Fulltext Access 4 Pages 2007
Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury Fulltext Access 4 Pages 2007
Synthesis of the new pseudo-symmetrical tamoxifen derivatives and their anti-tumor activity Fulltext Access 4 Pages 2007
Synthesis and biodistribution of 8-iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine Fulltext Access 4 Pages 2007
Synthesis and characterization of a perchlorotriphenylmethyl (trityl) triester radical: A potential sensor for superoxide and oxygen in biological systems Fulltext Access 4 Pages 2007
ERβ ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor β-selective ligands Fulltext Access 4 Pages 2007
Separation and determination of closely related triterpenic acids by high performance thin-layer chromatography after iodine derivatization Fulltext Access 4 Pages 2007
Quantitation of Armillarisin A in human plasma by liquid chromatography–electrospray tandem mass spectrometry Fulltext Access 4 Pages 2007
LC/ESI-MS method for the determination of trimetazidine in human plasma: Application to a bioequivalence study on Chinese volunteers Fulltext Access 4 Pages 2007
A liquid chromatography/tandem mass spectrometry assay to quantitate MS-275 in human plasma Fulltext Access 4 Pages 2007
Isocratic RP-HPLC method for rutin determination in solid oral dosage forms Fulltext Access 4 Pages 2007
High performance liquid chromatographic determination of a new antifungal compound, ADKZ in rat plasma Fulltext Access 4 Pages 2007
Determination of Huperzine A in rat plasma by high-performance liquid chromatography with a fluorescence detector Fulltext Access 4 Pages 2007
Validation of a capillary electrophoresis method for the analysis of ibandronate related impurities Fulltext Access 4 Pages 2007
Evaluation of the antimicrobial mode of berberine by LC/ESI-MS combined with principal component analysis Fulltext Access 4 Pages 2007
Experimental design and capillary electrophoresis for simultaneous analysis of arbutin, kojic acid and hydroquinone in cosmetics Fulltext Access 4 Pages 2007
Study of the photostability of 18 sunscreens in creams by measuring the SPF in vitro Fulltext Access 4 Pages 2007
Assessment of the solid-state composition of an active salicylanilide compound by FT-Raman spectroscopy Fulltext Access 4 Pages 2007
Quantification of carvedilol in human plasma by liquid chromatography using fluorescence detection: Application in pharmacokinetic studies Fulltext Access 4 Pages 2007
Efficiency improvement for sulfated ash determination by usage of a microwave muffle furnace Fulltext Access 4 Pages 2007
Fluorimetric SIA optosensing in pharmaceutical analysis: Determination of paracetamol Fulltext Access 4 Pages 2007
Purification of [18F]-fluoro-l-thymidine ([18F]-FLT) for positron emission tomography imaging Fulltext Access 4 Pages 2007
Simultaneous determination of three aconitum alkaloids in urine by LC-MS-MS Fulltext Access 4 Pages 2007
Determination of purine and pyrimidine bases in natural and cultured Cordyceps using optimum acid hydrolysis followed by high performance liquid chromatography Fulltext Access 4 Pages 2007
Caution to HPLC analysis of tricarbonyl technetium radiopharmaceuticals: An example of changing constitution of complexes in column Fulltext Access 4 Pages 2007
Solid-state characterization of two polymorphic forms of R-albuterol sulfate Fulltext Access 4 Pages 2007
Quantitative determination and sampling of azathioprine residues for cleaning validation in production area Fulltext Access 4 Pages 2007
Determination of free isomeric oleanolic acid and ursolic acid in Pterocephalus hookeri by capillary zone electrophoresis Fulltext Access 4 Pages 2007
Simultaneous determination of four bioactive constituents in Liuwei Dihuang Pills by micellar electrokinetic chromatography Fulltext Access 4 Pages 2007
Validation of an isocratic LC method for determination of quercetin and methylquercetin in topical nanoemulsions Fulltext Access 4 Pages 2007
Rapid method to study the sedimentation of a pigment suspension prepared for coating fluids Fulltext Access 4 Pages 2007
Arene cis-dihydrodiols: Useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) Fulltext Access 4 Pages 2007
Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives Fulltext Access 4 Pages 2007
Cytostatic evaluations of nucleoside analogs related to unnatural base pairs for a genetic expansion system Fulltext Access 4 Pages 2007
Discovery and structure-activity relationships of new steroidal compounds bearing a carboxy-terminal side chain as androgen receptor pure antagonists Fulltext Access 4 Pages 2007
Benzopyrans as selective estrogen receptor β agonists (SERBAs). Part 5: Combined A- and C-ring structure–activity relationship studies Fulltext Access 4 Pages 2007
Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries Fulltext Access 4 Pages 2007
Discovery of novel and orally active NR2B-selective N-methyl-d-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity Fulltext Access 4 Pages 2007
Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production Fulltext Access 4 Pages 2007
Optimization of triarylimidazoles for Tie2: Influence of conformation on potency Fulltext Access 4 Pages 2007
Preparation and in vitro anti-staphylococcal activity of novel 11-deoxy-11-hydroxyiminorifamycins Fulltext Access 4 Pages 2007
Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities Fulltext Access 4 Pages 2007
On the search of new I2-IBS aliphatic ligands: Bis-guanidino carbonyl derivatives Fulltext Access 4 Pages 2007
Simultaneous determination of amoxicillin and clavulanic acid in human plasma by isocratic reversed-phase HPLC using UV detection Fulltext Access 4 Pages 2007
Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxides Fulltext Access 4 Pages 2007
Synthesis and in vitro evaluation of a selective antagonist and the corresponding radioligand for the prostaglandin D2 receptor CRTH2 Fulltext Access 4 Pages 2007
Synthesis and biological activities of glycosphingolipid analogues from marine sponge Aplysinella rhax Fulltext Access 4 Pages 2007
Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors Fulltext Access 4 Pages 2007
Design and synthesis of opioidmimetics containing 2â²,6â²-dimethyl-l-tyrosine and a pyrazinone-ring platform Fulltext Access 4 Pages 2007
Synthesis and identification of novel 11β-aryl-4â²,5â²-dihydrospiro[estra-4,9-diene-17β,4â²-oxazole] analogs with dissociated antiprogesterone activities Fulltext Access 4 Pages 2007
Enantiospecific assay of citadiol—A key intermediate of escitalopram by liquid chromatography on Chiralpak AD-H column connected with UV and polarimetric detectors in series Fulltext Access 4 Pages 2007
Rapid on-line extraction and quantification of escitalopram from urine using sol–gel columns and mass spectrometric detection Fulltext Access 4 Pages 2007
Simultaneous determination of betulin and betulinic acid in white birch bark using RP-HPLC Fulltext Access 4 Pages 2007