Stereoselective synthesis of a novel 2-aza-7-oxabicyclo[3.3.0]octane as neurokinin-1 receptor antagonist Fulltext Access 4 Pages 2007
Synthesis and evaluation of prodrugs for anti-angiogenic pyrrolylmethylidenyl oxindoles Fulltext Access 4 Pages 2007
Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor Fulltext Access 4 Pages 2007
Antibody catalyzed hydrolysis of a quorum sensing signal found in Gram-negative bacteria Fulltext Access 4 Pages 2007
Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones Fulltext Access 4 Pages 2007
Novel hydroxamic acid-related phosphinates: Inhibition of neutral aminopeptidase N (APN) Fulltext Access 4 Pages 2007
Probing binding requirements of NAD kinase with modified substrate (NAD) analogues Fulltext Access 4 Pages 2007
The role of fluorine substitution in the structure–activity relationships (SAR) of classical cannabinoids Fulltext Access 4 Pages 2007
Investigation of the terminal P4 domain in a series of d-phenylglycinamide-based factor Xa inhibitors Fulltext Access 4 Pages 2007
Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents Fulltext Access 4 Pages 2007
Synthesis of andrographolide derivatives and their TNF-α and IL-6 expression inhibitory activities Fulltext Access 4 Pages 2007
Efficient synthesis and biological evaluation of ω-oxygenated analogues of vitamin K2: Study of modification and structure–activity relationship of vitamin K2 metabolites Fulltext Access 4 Pages 2007
Novel sequence-responding fluorescent oligoDNA probe bearing a silylated pyrene molecule Fulltext Access 4 Pages 2007
A polyacetylene compound from herbal medicine regulates genes associated with thrombosis in endothelial cells Fulltext Access 4 Pages 2007
Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target Fulltext Access 4 Pages 2007
Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38αMAPK inhibitors in Werner syndrome cells Fulltext Access 4 Pages 2007
Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents Fulltext Access 4 Pages 2007
Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase Fulltext Access 4 Pages 2007
Dipeptidyl-α,β-epoxyesters as potent irreversible inhibitors of the cysteine proteases cruzain and rhodesain Fulltext Access 4 Pages 2007
Highly regioselective enzymatic synthesis of polymerizable derivatives of methyl shikimate Fulltext Access 4 Pages 2007
New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus Fulltext Access 4 Pages 2007
Nitrogen-containing flavonoids as CDK1/Cyclin B inhibitors: Design, synthesis, and biological evaluation Fulltext Access 4 Pages 2007
Design, synthesis, and biological evaluation of novel analogues of archazolid: A highly potent simplified V-ATPase inhibitor Fulltext Access 4 Pages 2007
Enantioselective synthesis and vanilloid activity evaluation of 1-β-(p-methoxycinnamoyl)polygodial, an antinociceptive compound from Drymis winteri barks Fulltext Access 4 Pages 2007
Synthesis, in vitro inhibitory activity towards COX-2 and haemolytic activity of derivatives of Esculentoside A Fulltext Access 4 Pages 2007
Xanthones from Cudrania Tricuspidata displaying potent α-glucosidase inhibition Fulltext Access 4 Pages 2007
Stereoselective synthesis and cytotoxicity of a cancer chemopreventive naphthoquinone from Tabebuia avellanedae Fulltext Access 4 Pages 2007
Synthesis of novel diaryl ethers and their evaluation as antimitotic agents Fulltext Access 4 Pages 2007
Synthesis of potent and tissue-selective androgen receptor modulators (SARMs): 2-(2,2,2)-Trifluoroethyl-benzimidazole scaffold Fulltext Access 4 Pages 2007
Specific stabilization of DNA triple helices by indolo[2,1-b]quinazolin-6,12-dione derivatives Fulltext Access 4 Pages 2007
Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site Fulltext Access 4 Pages 2007
N-Caffeoylphenalkylamide derivatives as bacterial efflux pump inhibitors Fulltext Access 4 Pages 2007
Butyl 2-(4-[1.1′-biphenyl]-4-yl-1H-imidazol-2-yl)ethylcarbamate, a potent sodium channel blocker for the treatment of neuropathic pain Fulltext Access 4 Pages 2007
Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists Fulltext Access 4 Pages 2007
A spectroscopic and molecular modeling study of sinomenine binding to transferrin Fulltext Access 4 Pages 2007
Further studies on the binding of N1-substituted tryptamines at h5-HT6 receptors Fulltext Access 4 Pages 2007
A novel, non-substrate-based series of glycine type 1 transporter inhibitors derived from high-throughput screening Fulltext Access 4 Pages 2007
Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones Fulltext Access 4 Pages 2007
Inhibition of the mitochondrial F1F0-ATPase by ligands of the peripheral benzodiazepine receptor Fulltext Access 4 Pages 2007
Structure–activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors Fulltext Access 4 Pages 2007
3H-[1,2,4]-Triazolo[5,1-i]purin-5-amine derivatives as adenosine A2A antagonists Fulltext Access 4 Pages 2007
Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity Fulltext Access 4 Pages 2007
Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase Fulltext Access 4 Pages 2007
In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites Fulltext Access 4 Pages 2007
A novel butyrolactone derivative inhibited apoptosis and depressed integrin β4 expression in vascular endothelial cells Fulltext Access 4 Pages 2007
Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase Fulltext Access 4 Pages 2007
Design and synthesis of substrate-mimic inhibitors of mycothiol-S-conjugate amidase from Mycobacterium tuberculosis Fulltext Access 4 Pages 2007
5-HT2C antagonists based on fused heterotricyclic templates: Design, synthesis and biological evaluation Fulltext Access 4 Pages 2007
New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase Fulltext Access 4 Pages 2007
Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: From anti-pestivirus to anti-hepatitis C virus activity Fulltext Access 4 Pages 2007
Trimethylsilylpyrazoles as novel inhibitors of p38 MAP kinase: A new use of silicon bioisosteres in medicinal chemistry Fulltext Access 4 Pages 2007
From dihydroxypyrimidine carboxylic acids to carboxamide HIV-1 integrase inhibitors: SAR around the amide moiety Fulltext Access 4 Pages 2007
Antitumor activity of the marine natural product dibromophakellstatin in vitro Fulltext Access 4 Pages 2007
New carbon-linked azole oxazolidinones with improved potency and pharmacokinetics Fulltext Access 4 Pages 2007
Synthesis and evaluation of peptidic maleimides as transglutaminase inhibitors Fulltext Access 4 Pages 2007
Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors Fulltext Access 4 Pages 2007
Newer tetracycline derivatives: Synthesis, anti-HIV, antimycobacterial activities and inhibition of HIV-1 integrase Fulltext Access 4 Pages 2007
Application of the Suzuki–Miyaura cross-coupling to increase antimicrobial potency generates promising novel antibacterials Fulltext Access 4 Pages 2007
Preparation of novel antibacterial agents. Replacement of the central aromatic ring with heterocycles Fulltext Access 4 Pages 2007
Evaluation of fluorescently labeled xylopyranosides as probes for proteoglycan biosynthesis Fulltext Access 4 Pages 2007
Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of unsymmetrical 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives Fulltext Access 4 Pages 2007
An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: Synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-β-d-ribofuranoside Fulltext Access 4 Pages 2007
Synthesis and structure–activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands Fulltext Access 4 Pages 2007
Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents Fulltext Access 4 Pages 2007
Structure–activity delineation of quinones related to the biologically active Calothrixin B Fulltext Access 4 Pages 2007
CCR5 receptor antagonists: Discovery and SAR study of guanylhydrazone derivatives Fulltext Access 4 Pages 2007
Identification of a series of highly potent activators of the Nurr1 signaling pathway Fulltext Access 4 Pages 2007
SAR studies of 6-(arylamino)-4,4-disubstituted-1-methyl-1,4-dihydro-benzo[d][1,3]oxazin-2-ones as progesterone receptor antagonists Fulltext Access 4 Pages 2007
Mono, di and tri-mannopyranosyl phosphates as mannose-1-phosphate prodrugs for potential CDG-Ia therapy Fulltext Access 4 Pages 2007
Structure–activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The homovanillyl moiety Fulltext Access 4 Pages 2007
The discovery of a potent orally efficacious indole androgen receptor antagonist through in vivo screening Fulltext Access 4 Pages 2007
Ponapensin, a cyclopenta[bc]benzopyran with potent NF-κB inhibitory activity from Aglaia ponapensis Fulltext Access 4 Pages 2007
Intermediate analogue inhibitors of mandelate racemase: N-Hydroxyformanilide and cupferron Fulltext Access 4 Pages 2007
Ezetimibe analogs with a reorganized azetidinone ring: Design, synthesis, and evaluation of cholesterol absorption inhibitions Fulltext Access 4 Pages 2007
Synthesis and structure–activity studies of antofine analogues as potential anticancer agents Fulltext Access 4 Pages 2007
Novel thiol-based TACE inhibitors: Rational design, synthesis, and SAR of thiol-containing aryl sulfonamides Fulltext Access 4 Pages 2007
Antibiotic-conjugated polyacrylate nanoparticles: New opportunities for development of anti-MRSA agents Fulltext Access 4 Pages 2007
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes Fulltext Access 4 Pages 2007
Kojic acid and its manganese and zinc complexes as potential radioprotective agents Fulltext Access 4 Pages 2007
Samarium(II) promoted stereoselective synthesis of antiproliferative cis-β-alkoxy-γ-alkyl-γ-lactones Fulltext Access 4 Pages 2007
Novel nucleotide triphosphates as potent P2Y2 agonists with enhanced stability over UTP Fulltext Access 4 Pages 2007
Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions Fulltext Access 4 Pages 2007
Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor Fulltext Access 4 Pages 2007