ReviewInsulin: Its role in the central control of reproduction
Keywords: Insulin receptors; Hypothalamus; GnRH; Kisspeptin; AgRP; POMC;
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Hypothalamic KLF4 mediates leptin's effects on food intake via AgRP
Keywords: AgRP; Food intake; Leptin
Ablation of AgRP neurons impairs adaption to restricted feeding
Keywords: AgRP; Hypothalamus; Food anticipatory activity (FAA); Food entrainable oscillator (FEO)
Thiamine deficiency induces anorexia by inhibiting hypothalamic AMPK
Keywords: α-MSH; α-melanocyte-stimulating hormone; AgRP; agouti-related peptide; AMPK; adenosine monophosphate-activated protein kinase; ANOVA; one-way analysis of variance; ARH; arcuate hypothalamus; BAT; brown adipose tissue; DMH; dorsomedial nucleus; IHC; immu
Undernutrition during early life alters neuropeptide Y distribution along the arcuate/paraventricular pathway
Keywords: 3V; third ventricle; AGRP; Agouti-related peptide; ANOVA; analyses of variance; ARC; arcuate nucleus; CART; cocaine/amphetamine-regulated transcript; CG; control group; DMH; dorsomedial hypothalamic region; ELISA; enzyme-linked immunosorbent assay; NADPH;
Repeated agouti related peptide (83-132) injections inhibit cocaine-induced locomotor sensitisation, but not via the nucleus accumbens
Keywords: Cocaine; AgRP; Locomotor sensitisation; Nucleus accumbens;
Expression of neuropeptide Y and agouti-related protein mRNA stimulated by glucocorticoids is attenuated via NF-κB p65 under ER stress in mouse hypothalamic cultures
Keywords: ER; endoplasmic reticulum; NPY; neuropeptide Y; AgRP; agouti-related protein; UPR; unfolded protein response; TG; thapsigargin; TN; tunicamycin; DEX; dexamethasone; GR; glucocorticoid receptor; p38 MAPK; p38 mitogen-activated protein kinases; Agouti-relat
Conjugated linoleic acid and phytosterols counteract obesity induced by high-fat diet
Keywords: CLA; conjugated linoleic acid; AIN-93G; American Institute of Nutrition; GTT; glucose tolerance test; ITT; insulin tolerance test; ANOVA; analysis of variance; NPY; neurons co-expressing neuropeptide Y; AgRP; agoutigene-related protein; POMC; neurons co-e
Increased food intake in growth hormone-transgenic common carp (Cyprinus carpio L.) may be mediated by upregulating Agouti-related protein (AgRP)
Keywords: Growth hormone; AgRP; NPY; Food intake; Transgenic; Common carp;
Cloning, distribution and effects of fasting status of melanocortin 4 receptor (MC4R) in Schizothorax prenanti
Keywords: MC; melanocortin; MCRs; melanocortin receptors; GPCRs; G protein-coupled receptors; FTO; obesity-associated; POMC; proopiomelanocortin; α-MSH; α-melanocyte-stimulating hormone; AgRP; agouti-related protein; NPY; neuropeptide Y; MS-222; tricaine methanes
Characterization, tissue distribution and regulation of agouti-related protein (AgRP) in a cyprinid fish (Schizothorax prenanti)
Keywords: AgRP; agouti-related protein; ORF; Open reading frame; ARC; arcuate nucleus; NPY; neuropeptide Y; POMC; proopiomelanocortin; CART; cocaine and amphetamine regulated transcript; MCRs; melanocortin receptors; MC3-R; melanocortin receptor 3; MC4-R; melanocor
Research ReportInfluence of the core circadian gene “Clock” on obesity and leptin resistance in mice
Keywords: JAK2; Janus-activating kinase 2; STAT3; signal transducer and activators of transcription 3; NPY; neuropeptide Y; AgRP; agouti-related protein; CNS; central nervous system; POMC; proopiomelanocortin; SOCS-3; suppressor of cytokine signaling-3; ARC; arcuat
An eGFP-expressing subpopulation of growth hormone secretagogue receptor cells are distinct from kisspeptin, tyrosine hydroxylase, and RFamide-related peptide neurons in mice
Keywords: Ghrelin; GHSR; GFP; Kisspeptin; AgRP; Reproduction;
The hypothalamic POMC mRNA expression is upregulated in prenatally undernourished male rat offspring under high-fat diet
Keywords: DOHaD; developmental origin of health and disease; C; control; FR30; offspring from 70% food-restricted pregnant dams; IUGR; intrauterine growth retardation; MPU; maternal prenatal undernutrition; LP; low protein diet; WAT; white adipose tissue; BAT; brow
Adolescent binge-like ethanol exposure reduces basal α-MSH expression in the hypothalamus and the amygdala of adult rats
Keywords: AA Alko; alcohol rats; AgRP; agouti-related peptide; ANA Alko; non alcohol rats; Arc; hypothalamic arcuate nucleus; BEC; blood ethanol concentration; BEP; binge-like ethanol pre-treatment group; BNST; bed nucleus of the stria terminalis; BW; body weight;
Neuropeptide Y stimulates food intake and regulates metabolism in grass carp, Ctenopharyngodon idellus
Keywords: AgRP; agouti-related peptide; AMY; amylase; BW; body weight; CART; cocaine and amphetamine regulated transcript; CCK; cholecystokinin; CNS; central nervous system; CRF; corticotropin-releasing factor; EST; expressed sequence tag; GH; growth hormone; ICV;
Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
Keywords: AGRP; agouti-related protein; AMPK; AMP-activated protein kinase; AP-1; activator protein-1; BCL10; B-cell lymphoma/leukemia-10; CIITA; class II, major histocompatibility complex, transactivator; DHA; docosahexaenoic acid; E2F1; transcription factor E2F1;
Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: Potential therapeutic targets for cardiac cachexia
Keywords: Ang II; angiotensin II; AT1R; angiotensin II type 1 receptor; CHF; congestive heart failure; ESRD; end-stage renal disease; ACE; angiotensin-converting enzyme; UPS; ubiquitin proteasome system; ROS; reactive oxygen species; IGF-1; insulin-like growth fact
Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling
Keywords: AMPK; AMP-activated protein kinase; AgRP; agouti-related protein; CAMKK2; calmodulin-dependent kinase kinase 2; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; GHS-R1a; growth hormone secretagogue receptor type 1a; ICV; intracerebroventricular; mTORC1;
Food-intake dysregulation in type 2 diabetic Goto-Kakizaki rats: Hypothesized role of dysfunctional brainstem thyrotropin-releasing hormone and impaired vagal output
Keywords: AgRP; agouti-related peptide; Amb; nucleus ambiguus; AP; area postrema; BW; body weight; DMV; dorsal motor nucleus of the vagus; DVC; dorsal vagal complex; F48h; 48Â h fasted; GHSR; ghrelin receptor; GIP; glucose-dependent insulinotropic polypeptide; GK r
Kisspeptin as a link between metabolism and reproduction: Evidences from rodent and primate studies
Keywords: KP; Kissspeptin; GnRH; Gonadotropin Releasing Hormone; ARC; Arcuate Nucleus; NPY; Neuropeptide Y; AgRP; Agouti Related Protein; GALP; Galanin-like Peptide; MCH; Melanin-Concentrating Hormone; POMC; Proopiomelanocortin; CART; Cocaine- and Amphetamine-Relat
The role of nitric oxide signaling in food intake; insights from the inner mitochondrial membrane peptidase 2 mutant mice
Keywords: Immp2l; IMP2 inner mitochondrial membrane peptidase-like; cGMP; cyclic guanosine monophosphate; ROS; reactive oxygen species; UCP2; uncoupling protein 2; NPY; neuropeptide Y; AgRP; agouti related protein; POMC; pro-opiomelanocortin; NO; nitric oxide; NOS;
Reduced AgRP activation in the hypothalamus of cows with high extent of fat mobilization after parturition
Keywords: AgRP; NEFA; Oxygen consumption; Respiratory quotient; Early lactation; Dairy cow
Regulation of prolactin in mice with altered hypothalamic melanocortin activity
Keywords: ACTH; adrenocorticotropin; AgRP; agouti-related protein; β-EP; β-endorphin; CMV; cytomegalovirus; D2R; dopamine type-2 receptor; DHBA; 3,4-dihydroxybenzylamine; DOPA; 3,4-dihydroxyphenylalanine; DOPAC; 3,4-dihydroxyphenylacetic acid; MBH; mediobasal hyp
Effect of dietary fatty acid composition on food intake, triglycerides, and hypothalamic peptides
Keywords: AgRP; agouti-related protein; ARC; arcuate nucleus; GAL; galanin; HiSat; diet with relatively high levels of saturated fatty acids; NPY; neuropeptide Y; ns; not significant; OX; orexin; PFLH; perifornical lateral hypothalamus; PVN; paraventricular nucleus
Incorporation of conjugated linoleic acid into brain lipids is not necessary for conjugated linoleic acid-induced reductions in feed intake or body fat in mice
Keywords: Conjugated linoleic acid; Brain; Adipose tissue; Insulin; Mouse; AgRP; agouti-related protein; α-MSH; α-melanocyte-stimulating hormone; BF; body fat; CLA; conjugated linoleic acid; EPI; epididymal; FI; feed intake; ICV; intracerebroventricular; MUFA;
G-protein-gated inwardly rectifying K+ channel 4 (GIRK4) immunoreactivity in chemically defined neurons of the hypothalamic arcuate nucleus that control body weight
Keywords: AgRP; Body weight; Hypothalamus; Obesity; POMC;
Fto colocalizes with a satiety mediator oxytocin in the brain and upregulates oxytocin gene expression
Keywords: AgRP; Agouti-related protein; NPY; neuropeptide Y; POMC; proopiomelanocortin; PVN; paraventricular hypothalamic nucleus; SON; supraoptic nucleus; Obesity; Feeding; Brain;
Perspectives on endocrine disruptor effects on metabolic sensors
Keywords: EDs; endocrine disruptors; DEHP; dietylexilphthalate; DDT; dichloro-diphenyl-trichloroethane; DES; diethylstilbestrol; BPA; bisphenol A; PCBs; polychlorinated biphenyls; TCDD; tetrachlorodibenzo-p-dioxin; HxCDD; hexachlorodibenzo-p-dioxin; PEPCK; phosphoe
Central mechanisms involved in the orexigenic actions of ghrelin
Keywords: NPY; AgRP; Ghrelin; Ghrelin resistance; Intracellular; CaMKK; AMPK; CPT1; UCP;
Melanocortin activity in the amygdala influences alcohol intake
Keywords: AgRP; agouti-related protein; AP/L/V; anterior-posterior/lateral/ventral; CeA; central nucleus of amygdala; GABA; gamma amino butyric acid; icv; intracerebroventricular; MC3R; melanocortin 3 receptor; MC4R; melanocortin 4 receptor; αMSH; alpha melanocy
Implication of the melanocortin-3 receptor in the regulation of food intake
Keywords: Melanotropin; MC3R; MC4R; Knockout mice; Obesity; Food intake; Feeding; Energy homeostasis; AGRP; SHU9119
Postprandial effects on appetite-related neuropeptide expression in the brain of Atlantic salmon, Salmo salar
Keywords: cart; npy; pyy; cck; agrp; pomc; Isoforms; Teleost; Appetite; Neuropeptide
Telmisartan suppresses food intake in mice via the melanocortin pathway
Keywords: ARB; Food intake; AgRP; α-MSH; Melanocortin receptor
The early origin of melanocortin receptors, agouti-related peptide, agouti signalling peptide, and melanocortin receptor-accessory proteins, with emphasis on pufferfishes, elephant shark, lampreys, and amphioxus
Keywords: ASIP; AgRP; Melanocortin receptor; MRAP; (Elephant shark); (Sea lamprey)
Oleoylethanolamide: Effects on hypothalamic transmitters and gut peptides regulating food intake
Keywords: Hypothalamus; NPY; AgRP; CART; Monoamines; Satiety
Acute and repeated restraint differentially activate orexigenic pathways in the rat hypothalamus
Keywords: HPA axis; PVH; ARC; LHA; Fos; MC4R; AgRP; GLP1R;
Alternative G protein coupling and biased agonism: New insights into melanocortin-4 receptor signalling
Keywords: ACTH; adrenocorticotropic hormone; cAMP; cyclic 3â²,5â²-adenosine monophosphate; AGRP; agouti-related protein; CTX; cholera toxin; ER; endoplasmic reticulum; ERK-1/2; extracellular signal-regulated kinases; FSK; forskolin; GPCR; G protein-coupled recept
Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity
Keywords: Ghrelin; NPY; AgRP; Spontaneous physical activity; Locomotion
VGF: An inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkers
Keywords: AGRP; agouti related peptide; BDNF; brain derived growth factor; cAMP; cyclic adenosine monophosphate; CSF; cerebro-spinal fluid; NGF; nerve growth factor; NPY; neuropeptide Y (tyrosine); POMC; proopiomelanocortin; VIP; vasoactive intestinal polypeptide;
The role of NPY in hypothalamic mediated food intake
Keywords: 2-AG; 2-arachidonoylglycerol; AAV; adeno associated virus; AEA; N-arachidonoylethanolamide/anandamide; AgRP; agouti-related peptide; α-MSH; alpha melanocyte stimulating hormone; ARC; arcuate nucleus; BBB; blood-brain barrier; CART; cocaine and amphetam
Dietary l-leucine supplementation of lactating rats results in a tendency to increase lean/fat ratio associated to lower orexigenic neuropeptide expression in hypothalamus
Keywords: Leucine supplementation; Lactation; NPY; AgRP; POMC; CART
Differential effect of prolonged food restriction and fasting on hypothalamic malonyl-CoA concentration and expression of orexigenic and anorexigenic neuropeptides genes in rats
Keywords: Malonyl-CoA; NPY; AgRP; CART; POMC;
Solid-phase peptide head-to-side chain cyclodimerization: Discovery of C2-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors
Keywords: All; allyl; AgRP; Agouti-related protein; ASIP; agouti-signaling protein; Boc; tert-butyloxycarbonyl; Fmoc; fluorenylmethoxycarbonyl; CH3CN; acetonitrile; Cl-HOBt; 1-hydroxy-6-chlorobenzotriazole; DCM; dichloromethane; DIPEA; diisopropylethylamine; DMF; N
Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake
Keywords: microarray; RT-PCR; opiates; pituitary; hypothalamus; food intake; ACTH; adrenocorticotropic hormone; Adpn; adiponutrin; AgRP; agouti-related peptide; α-MSH; α-melanocyte-stimulating hormone; CART; cocaine and amphetamine regulated transcript; Cdcn1a; c
Sleeve Gastrectomy Induces Loss of Weight and Fat Mass in Obese Rats, but Does Not Affect Leptin Sensitivity
Keywords: Bariatric Surgery; Hypothalamus; Arcuate; Stomach; AgRP; agouti-related peptide; CNS; central nervous system; MBH; mediobasal hypothalamus; NPY; neuropeptide Y; PF; pair-fed; POMC; pro-opiomelanocortin; RQ; respiratory quotient; VSG; vertical sleeve gastr
Cross-talk between adipose and gastric leptins for the control of food intake and energy metabolism
Keywords: ACTH; adrenocorticotropic hormone; ADIPOR1/2; adiponectin receptor1/2; AgRP; agouti related protein; AMPK; AMP-activated protein kinase; BSDL; bile salt-dependent lipase; cAMP; cyclic adenosine-monophosphate; CART; cocaine amphetamine related transcript;
Central lactate metabolism suppresses food intake via the hypothalamic AMP kinase/malonyl-CoA signaling pathway
Keywords: ACC; acetyl-CoA carboxylase; NPY; neuropeptide Y; AgRP; Aguoti regulated peptide; POMC; proopiomelanocortin; CART; cocaine and amphetamine-regulated transcript; G6P; glucose-6-phosphate; CNS; central nervous system; BBB; blood-brain barrier; 2-DG; 2-deo
Rutecarpine ameliorates bodyweight gain through the inhibition of orexigenic neuropeptides NPY and AgRP in mice
Keywords: Rutecarpine; Obesity; Orexigenic; NPY; AgRP
Central insulin sensitivity in male and female juvenile rats
Keywords: Food intake; Meal patterns; Glucose; Hypothalamus; Feeding; Sex differences; NPY; AgRP; POMC