Inhibitory effect of ERK1/2 and AP-1 by hyperoside isolated from Acanthopanax sessiliflorus
Keywords: Acanthopanax sessiliflorus; Hyperoside; ERK1/2; AP-1;
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Mast cell transcription factors—Regulators of cell fate and phenotype
Keywords: Mast cells transcription factor; IgE-Ag; AP-1; MITF
Glucocorticoids reduce inflammation in cystic fibrosis bronchial epithelial cells
Keywords: Aicar; 5-aminoimidazole-4-carboxamide-1-d-ribonucleoside; AMPK; AMP-activated protein kinase; AP-1; activator protein-1; CF; cystic fibrosis; CFTR; cystic fibrosis transmembrane conductance regulator; COPD; chronic obstructive pulmonary disease; CXCR; che
MKP-7, a negative regulator of JNK, regulates VCAM-1 expression through IRF-1
Keywords: ANOVA; analysis of variance; AP-1; activator protein-1; ChIP; chromatin immunoprecipitation; ECL; enhanced chemiluminescence; ECGS; endothelial cell growth supplements; ERK; extracellular regulated kinase; FBS; fetal bovine serum; HUVEC; human umbilical v
Src/NF-κB-targeted inhibition of LPS-induced macrophage activation and dextran sodium sulphate-induced colitis by Archidendron clypearia methanol extract
Keywords: PG; prostaglandin; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumor necrosis factor; ERK; extracellular signal-related kinase; TLR; Toll-like receptors (TLR); MAPK; mitogen activated protein kinase; NF-κB; nuclear facto
Cyanidin suppresses neoplastic cell transformation by directly targeting phosphatidylinositol 3-kinase
Keywords: EGF; epidermal growth factor; AP-1; activation of transcription factors activator protein-1; NF-κB; nuclear factor-kappaB; DPPH; 1,1-diphenyl-2-picrylhydrazyl; ABTS; 2,2â²-azinobis (3-ethylbenzothiazoline 6-sulphonate); ERK1/2; extracellular signal-regu
Theiler's murine encephalomyelitis virus induced phenotype switch of microglia in vitro
Keywords: AP-1; Astrocyte; Cytokine; Microglia; NF-κB; Theiler's murine encephalomyelitis virus;
Acyl chain-dependent effect of lysophosphatidylcholine on cyclooxygenase (COX)-2 expression in endothelial cells
Keywords: Lysophosphatidylcholine; COX-2; Endothelial cells; Calcium; Acyl-chain; Cell signaling; LPC; lysophosphatidylcholine; EL; endothelial lipase; 16:0 LPC; palmitoyl-lysophosphatidylcholine; 18:2 LPC; linoleoyl-LPC; 20:4 LPC; arachidonoyl-LPC; 18:1 LPC; oleoy
Focused ultrasound and interleukin-4 receptor-targeted liposomal doxorubicin for enhanced targeted drug delivery and antitumor effect in glioblastoma multiforme
Keywords: Focused ultrasound; AP-1; Targeted drug delivery; Blood–brain barrier; Brain tumor
Resveratrol inhibits Epstein Barr Virus lytic cycle in Burkitt's lymphoma cells by affecting multiple molecular targets
Keywords: RV; resveratrol; EBV; Epstein Barr Virus; IE; immediate early; E; early; NF-kB; nuclear factor kappa-light-chain-enhancer of activated B cells; AP-1; activator protein 1; Epstein Barr Virus; Resveratrol; Lytic infection; ROS; Protein synthesis; Transcri
Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-κB, C/EBP and AP-1 signaling pathways in murine macrophages
Keywords: PMA; phorbol 12-myristate 13-acetate; Cox-2; cyclooxygenase-2; NF-κB; nuclear factor-κB; C/EBP; CCAAT/enhancer binding protein (C/EBP); AP-1; activator protein-1; PVDF; polyvinylidene difluoride; DMSO; dimethyl sulfoxide; SDS-PAGE; sodium dodecyl sulf
Tanshinone IIA inhibits TNF-α-mediated induction of VCAM-1 but not ICAM-1 through the regulation of GATA-6 and IRF-1
Keywords: ANOVA; analysis of variance; AP-1; activator protein-1; ChIP; chromatin Immunoprecipitation; EC; endothelial cell; ECAM; endothelial cell adhesion molecule; ECGS; endothelial cell growth supplements; ECL; enhanced chemoluminescence; FBS; fetal bovine seru
The ability of an ethanol extract of Cinnamomum cassia to inhibit Src and spleen tyrosine kinase activity contributes to its anti-inflammatory action
Keywords: PG; prostaglandin; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumor necrosis factor; ERK; extracellular signal-related kinase; TLR; Toll-like receptors (TLR); MAPK; mitogen activated protein kinase; NF-κB; nuclear facto
Methanol extract of Osbeckia stellata suppresses lipopolysaccharide- and HCl/ethanol-induced inflammatory responses by inhibiting Src/Syk and IRAK1
Keywords: Os-ME; methanol extract of Osbeckia stellata; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; TNF-α; tumor necrosis factor-alpha; ERK; extracellular signal-related kinase; TLR; toll-like receptor; MAPK; mitogen
Src and Syk are targeted to an anti-inflammatory ethanol extract of Aralia continentalis
Keywords: PG; prostaglandin; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumour necrosis factor; ERK; extracellular signal-related kinase; TLR; Toll-like receptors (TLR); MAPK; mitogen activated protein kinase; NF-κB; nuclear fact
Up-regulation of IL-23 p19 expression in human periodontal ligament fibroblasts by IL-1β via concurrent activation of the NF-κB and MAPKs/AP-1 pathways
Keywords: Periodontitis; Periodontal ligament fibroblasts; IL-1; IL-23; NF-κB; nuclear factor-kappaB; MAPK; mitogen-activated protein kinase; JNK; c-Jun N-terminal kinase; ERK; extracellular-regulated kinase; AP-1; activator protein-1; IL-1Ra; IL-1 receptor antago
Cardiovascular actions and therapeutic potential of tanshinone IIA
Keywords: Ang-II; angiotensin II; AP-1; activator protein-1; ApoEâ/â; ApoE deficient; AT1R; type 1 Ang-II receptor; [Ca2+]i; intracellular calcium; CVD; cardiovascular diseases; CYP; cytochrome P450s; DOX; doxorubicin; eNOS; endothelial nitric oxide synthase; E
Fluid shear stress regulates metalloproteinase-1 and 2 in human periodontal ligament cells: Involvement of extracellular signal-regulated kinase (ERK) and P38 signaling pathways
Keywords: PDL; periodontal ligament; PGE2; prostaglandin E2; IL-8; interleukin-8; MMP; matrix metalloproteinase; TIMP; tissue inhibitors of metalloproteinase; MIP-1α; macrophage inflammatory protein-1α; AP-1; activator protein 1; Egr-1; early growth response prot
Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc
Keywords: Pdcd4; programmed cell death 4; MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1; AP-1; activator protein-1; TPA; 12-O-tetradecanoylphorbol-13-acetate; DMBA; 7,12-dimethylbenz(a)anthracene; TAK1; transforming growth factor βâactivated ki
MicroRNA 497 modulates interleukin 1 signalling via the MAPK/ERK pathway
Keywords: IL; interleukin; MAPK; mitogen-activated protein kinase; NFκB; nuclear factor κB; AP-1; jun proto-oncogene; ERK; extracellular signal-regulated kinase; JNK; c-Jun amino-terminal kinase; P38; mitogen-activated protein kinase 14; MEK; MAP Kinase kinase; R
Berberine suppresses high glucose-induced TGF-β1 and fibronectin synthesis in mesangial cells through inhibition of sphingosine kinase 1/AP-1 pathway
Keywords: Berberine; Mesangial cells; SphK1; AP-1; TGF-β1; FN;
Mixed lineage kinase 3 is required for matrix metalloproteinase expression and invasion in ovarian cancer cells
Keywords: MLK3; MMP; Invasion; Ovarian cancer; MAPK; AP-1
2′-Benzoyloxycinnamaldehyde inhibits nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells via regulation of AP-1 pathway
Keywords: Cinnamaldehyde; 2′-benzoyloxycinnamaldehyde; Lipopolysaccharide; Nitric oxide; AP-1; Atherosclerosis
Transcriptional regulation of human novel gene SPATA12 promoter by AP-1 and HSF
Keywords: SPATA12; spermatogenesis associated gene 12; AP-1; activator protein-1; HSF; heat shock factor; TGF-β; transcriptional growth factor-β; CREM; cAMP response element modulator; SRY; sex-determining region on the Y chromosome; GCR-1; germ cell restricted-1
TCR stimulation upregulates MS4a4B expression through induction of AP-1 transcription factor during T cell activation
Keywords: T cells; Gene promoter; AP-1; MS4A family
Identification of the Fra-1 transcription factor in healing skin flaps transplants: A potential role as a negative regulator of VEGF release from keratinocytes
Keywords: Wound healing; Transcription factor; Keratinocyte; Angiogenesis; AP-1
OxLDL causes both epigenetic modification and signaling regulation on the microRNA-29b gene: Novel mechanisms for cardiovascular diseases
Keywords: Atherosclerosis; AP-1; Histone modification; miR-29b; oxLDL;
Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-κB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells
Keywords: Alantolactone; Inflammation; NF-κB; MAPK; AP-1; Macrophage;
Combined α-tocopherol and ascorbic acid protects against smoke-induced lung squamous metaplasia in ferrets
Keywords: AP-1; activator protein-1; AT; α-tocopherol; AA; ascorbic acid; ERK; extracellular signal-regulated kinase; JNK; Jun N-terminal kinase; MAP; mitogen-activated protein; PCNA; proliferating cellular nuclear antigen; MDA; malondialdehyde; MEK; mitogen-activ
Intracellular redox equilibrium is essential for the constitutive expression of AP-1 dependent genes in resting cells: Studies on TGF-β1 regulation
Keywords: Reactive oxygen species; TGF-β1; Catalase; AP-1; Redox equilibrium
Vav1 in differentiation of tumoral promyelocytes
Keywords: GEF; guanosine exchange factor; APL; acute promyelocytic leukemia; ATRA; All-trans retinoic acid; LIC; leukemia initiating cells; PMA; phorbol 12-myristate 13-acetate; PIP; phosphatidylinositol 4-phosphate; PIP2; phosphatidylinositol 4, 5-bisphosphate; PI
The chloroethylating anticancer drug ACNU induces FRA1 that is involved in drug resistance of glioma cells
Keywords: AP-1; activator protein 1; FRA1; Fos-related antigen 1; DSB; DNA double-strand breaks; SSB; DNA single-strand breaks; ACNU; nimustine, (1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride; FRA1; ACNU; Glioma; Sensitivit
Increased inflammation and brain injury after transient focal cerebral ischemia in activating transcription factor 3 knockout mice
Keywords: AP-1; activator protein 1; ATF3; Activating transcription factor; CBF; cerebral blood flow; CREB; cAMP-responsive element-binding protein; HDAC1; histone deacetylase 1; ICAM; intercellular adhesion molecule; IL; interleukin; KO; knockout; MCA; middle cere
ESAT-6 induced COX-2 expression involves coordinated interplay between PI3K and MAPK signaling
Keywords: AP-1; activator protein-1; COX-2; cyclooxygenase-2; ESAT-6; early secreted antigenic target protein 6; MAPK; mitogen-activated protein kinase; NF-κB; nuclear factor-kappa B; PI3K; phosphoinositide 3-kinase; PGE2; prostaglandin E2; TLR2; toll-like recepto
Chitooligosaccharide elicits acute inflammatory cytokine response through AP-1 pathway in human intestinal epithelial-like (Caco-2) cells
Keywords: MW; molecular weight; Da; dalton; cDNA; complementary deoxyribonucleic acid; mRNA; messenger ribonucleic acid; TNF; tumor necrosis factor; AP-1; activator protein 1; NF-κB; nuclear factor kappa B; Inflammation; Intestinal epithelium; Chemokine; Functiona
Dioscorea nipponica Makino inhibits migration and invasion of human oral cancer HSC-3 cells by transcriptional inhibition of matrix metalloproteinase-2 through modulation of CREB and AP-1 activity
Keywords: DNE; 50% ethanol extract of Dioscorea nipponica; ECM; extracellular matrix; MMP; matrix metalloproteinase; u-PA; urokinase plasminogen activator; TIMP; tissue inhibitor of metalloproteinase; CREB; cAMP response element-binding; AP-1; activating protein-1;
CTB glycoprotein (75 kDa) inhibits IgE releasing, TNF-α and IL-6 expressed by bisphenol A in vivo and in vitro
Keywords: CTB; Cudrania tricuspidata Bureau; BPA; bisphenol A; IgE; immunoglobulin E; ERK; extracellular signal-regulated kinases; AP-1; activator protein-1; COX-2; cyclooxygenase-2; TNF-α; tumor necrosis factor-α; IL-6; interleukin-6; IL-1β; interleukin-1β; CT
Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): Anti-inflammatory and anti-cancer properties
Keywords: A2780; human ovarian carcinoma cells; AP-1; activator protein 1; ATF-2; activating transcription factor-2; ANOVA; analysis of variance; CD; cluster of differentiation; DMSO; Dimethyl sulfoxide; DMEM; Dulbecco's modified Eagle's medium; EF24; 3,5-Bis(2-flu
Ginsenoside Rh1 suppresses matrix metalloproteinase-1 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathway in human hepatocellular carcinoma cells
Keywords: Anti-metastasis; Ginsenoside Rh1; Invasion; Migration; AP-1; MMP-1;
Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1
Keywords: Diallyl trisulfide; Apoptosis; ROS; JNK; AP-1; MCF-7 cells;
Double-edged sword effect of biochanin to inhibit nuclear factor kappaB: Suppression of serine/threonine and tyrosine kinases
Keywords: AP-1; activator protein 1; C3-toxin; Clostridium botulinum C3 transferase; CE; cytoplasmic extracts; Cox2; cyclooxygenase 2; ICAM; intercellular adhesion molecule; NF-κB; nuclear transcription factor kappaB; IL; interleukin; IκB; inhibitory subunit of N
PPARδ prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-κB and inhibition of the PKCα/MEK1/2/ERK1/2/AP-1 pathway
Keywords: AP-1; activator protein-1; CNS; central nervous system; Cox-2; cyclooxygenase-2; ERK1/2; extracellular signal-related kinase 1/2; ICAM-1; intracellular cellular adhesion molecule-1; IL-1β; interleukin-1β; MCP-1; monocyte chemoattractant protein-1; MEK1/
Endosulfan upregulates AP-1 binding and ARE-mediated transcription via ERK1/2 and p38 activation in HepG2 cells
Keywords: Endosulfan; AP-1; ARE; ERK; p38; HepG2
Sulforaphane suppresses vascular adhesion molecule-1 expression in TNF-α-stimulated mouse vascular smooth muscle cells: Involvement of the MAPK, NF-κB and AP-1 signaling pathways
Keywords: Sulforaphane; Anti-inflammatory effect; Vascular cell adhesion molecule; MAPK; NF-κB; AP-1
Estradiol induces cytochrome P450 2B6 expression at high concentrations: Implication in estrogen-mediated gene regulation in pregnancy
Keywords: Pharmacokinetics; Drug metabolism; AP-1; activator protein 1; E2; 17β-estradiol; CYP; cytochrome P450; CAR; constitutive androstane receptor; ER; estrogen receptor; ERE; estrogen responsive element; HH; primary human hepatocyte; PBREM; the phenobarbital-
Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38
Keywords: AKT/PKB; protein kinase B; AP-1; activator protein-1; ARE; antioxidant response element; CHX; cycloheximide; DAPI; 6-diamidino-2-phenylindole; DTT; dithiothreitol; ERK; extracellular regulated kinase; FBS; fetal bovine serum; GAPDH; glyceraldehyde-3-phosp
Dynamics and regulation of lipid droplet formation in lipopolysaccharide (LPS)-stimulated microglia
Keywords: LD; lipid droplet; TG; triglyceride; TLR4; Toll-like receptor 4; LPS; lipopolysaccharides; ADRP; adipocyte differentiation-related protein; CNS; central nervous system; NO; nitric oxide; MAPK; mitogen-activated protein kinases; JNK; c-Jun N-terminal kinas
Emerging nonanticoagulant role of low molecular weight heparins on extravillous trophoblast functions and on heparin binding-epidermal growth factor and cystein-rich angiogenic inducer 61 expression
Keywords: Extravillous trophoblast invasiveness; low molecular weight heparins; tinzaparin; enoxaparin; HB-EGF; Cyr61; MMP-2; AP-1;
IL-13 dampens human airway epithelial innate immunity through induction of IL-1 receptor-associated kinase M
Keywords: IL-13; IL-1 receptor-associated kinase M; Toll-like receptor 2; airway epithelial cells; ALI; Air-liquid interface; AP-1; Activator protein 1; BEGM; Bronchial epithelial cell growth medium; GAPDH; Glyceraldehyde-3-phosphate dehydrogenase; hBD2; Human β