دانلود مقالات ISI درباره Ec50 + ترجمه فارسی

Research ArticleA randomized, double-blind, multiple-dose study of the pan-genotypic NS5A inhibitor samatasvir in patients infected with hepatitis C virus genotype 1, 2, 3 or 4

Keywords: HCV; hepatitis C virus; NS5A; nonstructural protein 5A; DAA; direct-acting antiviral agent; EC50; 50% effective concentration; CYP; cytochrome P450; HBV; hepatitis B virus; HIV; human immunodeficiency virus; QD; once daily; BID; twice daily; AE; adverse e

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibition

Keywords: CYP; cytochrome P450 gene or protein; T. cruzi; Trypanosoma cruzi; EC50; drug concentration that gives half-maximal response in cellular growth reduction; GFP; green fluorescent protein; SRS; substrate recognition site; VNI; ((R)-N-(1-(2,4-dichlorophenyl)

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Cytotoxicity and inhibition of P-glycoprotein by selected medicinal plants from Thailand

Keywords: ABC-transporter; ATP-binding cassette transporter; BBB; blood-brain barrier; Calcein-AM; calcein acetoxymethylester; EC50; 50% effective concentration; ECmax; maximal effective concentration; HPLC; high pressure liquid chromatography; IC50; 50% inhibito

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Identification of coregulators influenced by estrogen receptor subtype specific binding of the ER antagonists 4-hydroxytamoxifen and fulvestrant

Keywords: 4OHT; 4-hydroxytamoxifen; ATP; adenosine triphosphate; BSA; bovine serum albumin; CCD; charge coupled device; CDTA; 1,2-diaminocyclohexanetetraacetic acid monohydrate; DCC-FCS; dextran-coated charcoal-treated fetal calf serum; DMEM; Dulbecco's modified

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Optimizing the aquatic toxicity assessment under REACH through an integrated testing strategy (ITS)

Keywords: ACR; acute-to-chronic ratios; AF; assessment factor; BCF; bioconcentration factor; BOD5; 5-days biochemical oxygen demand; C&L; classification and labeling; CLP; classification, labeling and packaging; COD; chemical oxygen demand; CSA; chemical safety ass

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

The coating makes the difference: Acute effects of iron oxide nanoparticles on Daphnia magna

Keywords: NP; nanoparticles; NM; nanomaterials; nZVI; zero valent iron; IONP; iron oxide nanoparticles; ASC; ascorbate; CIT; citrate; DEX; dextran; PVP; polyvinylpyrrolidone; EC50; 50% effect concentration; HDD; hydrodynamic diameter; PTM; paratrophic membrane; Dap

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Original ResearchFull Report: Clinical-LiverEfficacy of an Interferon- and Ribavirin-Free Regimen of Daclatasvir, Asunaprevir, and BMS-791325 in Treatment-Naive Patients With HCV Genotype 1 Infection

Keywords: Liver Disease; Therapy; DAA; Drug Combination; EC50; median effective concentration; GT; genotype; HCV; hepatitis C virus; IL; interleukin; SVR; sustained virologic response; SVR24; sustained virologic response at 12 weeks;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir

Keywords: EC50; 50% effective inhibitory concentration; CsA/CsD; cyclosporine A/D; PPIase; peptidyl prolyl cis/trans isomerase; CypA/B; cyclophilin A/B; ALV; Alisporivir; FKBP; FK506-binding protein; HCoV-NL63; Cyclosporine/FK506-non-immunosuppressive derivatives;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

A robotic BG1Luc reporter assay to detect estrogen receptor agonists

Keywords: CCi; CertiChem, Inc.; CS; calf serum; DMSO; dimethyl sulfoxide; E2; 17β-estradiol; EA; estrogenic activity; EC50; half-maximal response of a test substance in its dose-response curve; EDC; endocrine disrupting chemical; EFM; EA-free medium; ER; estrogen

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Role of glutamine-169 in the substrate recognition of human aminopeptidase B

Keywords: APB; aminopeptidase B; IC50; half maximal (50%) inhibitory concentration; EC50; half maximal (50%) effective concentration; ERAP; endoplasmic reticulum aminopeptidase; LTA4H; leukotriene A4 hydrolase; MCA; 4-methylcoumaryl-7-amide; NRD; N-arginine dibasic

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

In vitro and in vivo anti-influenza virus activities of flavonoids and related compounds as components of Brazilian propolis (AF-08)

Keywords: ANOVA; analysis of variance;; BALF; bronchoalveolar lavage fluid;; CC50; 50% cytotoxic concentration;; DMSO; dimethylsulfoxide;; EC50; 50% effective concentration;; HPLC; high-performance liquid chromatograph;; LC-MS; liquid chromatography-mass spectromet

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Cell proliferation and modulation of interaction of estrogen receptors with coregulators induced by ERα and ERβ agonists

Keywords: ATP; adenosine triphosphate; BrdU; 5-bromo-2′-deoxyuridine; BSA; bovine serum albumin; CCD; charge coupled device; CDTA; 1,2-diaminocyclo-hexanetetraacetic acid; CHO; Chinese hamster ovary; DCC-FCS; dextran-coated charcoal-treated fetal calf serum; DMEM

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Love-Hate ligands for high resolution analysis of strain in ultra-stable protein/small molecule interaction

Keywords: D, Dead; non-binding streptavidin mutant; EC50; half-maximal effective concentration; L3/4; loop connecting β-strands 3 and 4; LH; Love-Hate ligand; rmsd; root mean square deviation; SA; wild-type core streptavidin; SAe; core streptavidin with C-termin

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Numerical simulations of in vitro nanoparticle toxicity - The case of poly(amido amine) dendrimers

Keywords: ROS; Reactive Oxygen Species; EC50; effective concentration 50%; QSAR; quantitative structure activity relationship; PAMAM; polyamidoamine; GSH; glutathione; MMPD; mitochondrial membrane depolarisation; TNF-α; tumour necrosis factor-alpha; IL-8; interleu

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes

Keywords: Plasmodium falciparum; PfCDPK4; PfCDPK1; Pyrazolopyrimidine; Exflagellation; ACT; artemisinin combination therapy; ATP; adenosine triphosphate; Boc; tert-butyloxycarbonyl; CAMKII; Ca2+/calmodulin-dependent protein kinase II; CDPK1; calcium-dependent prote

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Development of a robust reporter-based ADCC assay with frozen, thaw-and-use cells to measure Fc effector function of therapeutic antibodies

Keywords: ADCC; antibody-dependent cell-mediated cytotoxicity; CDC; complement-dependent cytotoxicity; PBMC; peripheral blood mononuclear cell; NK cells; natural killer cells; LDH; lactate dehydrogenase; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; EC50; measur

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

A hydrophobic residue in position 15 of the rP2X3 receptor slows desensitization and reveals properties beneficial for pharmacological analysis and high-throughput screening

Keywords: P2X3 receptor; Desensitization; Mechanism of antagonism; Drug screening; Calcium imaging; αß-meATP; αß-methylene-ATP; CI; confidence interval; EC50; 50% effective concentration; IC50; 50% inhibitory concentration; Ki; inhibition constant; pA2; negativ

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling

Keywords: BSA; bovine serum albumin; CHO; Chinese hamster ovary; CRC; concentration-response curve; EC50; half maximimal excitatory concentration; Emax; maximal efficacy versus a defined control; FBS; fetal bovine serum; GPCR; G protein coupled receptor; GRK; GPC

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Simeprevir With Peginterferon and Ribavirin Leads to High Rates of SVR in Patients With HCV Genotype 1 Who Relapsed After Previous Therapy: A Phase 3 Trial

Keywords: PROMISE; Chronic Hepatitis C; Drug; DAA; AE; adverse event; CI; confidence interval; DAA; direct-acting antiviral agent; EC50; median effective concentration; EOT; end of treatment; FDA; Food and Drug Administration; HCV; hepatitis C virus; IQR; interquar

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Eucommia ulmoides Oliv.: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine

Keywords: AChE; acetylcholinesterase; AD; Alzheimer's disease; AIDS; acquired immunodeficiency syndrome; Ang II; angiotensin II; AST; aspartate transaminase; BAT-SNA; Brown adipose tissue sympathetic nerve activity; cAMP; cyclic adenosine monophosphate; CJ-S (131);

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus

Keywords: GluK; kainate receptor; PGE2; prostaglandin E2; PGF2α; prostaglandin F2α; EP1; prostaglandin E2 receptor 1; EP2; prostaglandin E2 receptor 2; EP1-KO; prostaglandin E2 receptor 1 knockout mice; WT; C57Bl/6 wildtype mice; EC50; half maximal effective conc

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2014 سفارش ترجمه

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

Keywords: Group 2 innate lymphoid cell; PGD2; chemoattractant receptor-homologous molecule expressed on TH2 cells; IL-25; IL-33; innate type 2 immunity; adaptive type 2 immunity; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 cells; CSF-1; Mac

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2014 سفارش ترجمه

trans-Caryophyllene is a natural agonistic ligand for peroxisome proliferator-activated receptor-α

Keywords: PPAR; peroxisome proliferator-activated receptor; LBD; ligand-binding domain; SPR; surface plasmon resonance; TR-FRET; time-resolved fluorescent resonance energy transfer; TG; triglyceride; HTG; hypertriglyceridemia; RXR; retinoid X receptor; EO; essentia

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2014 سفارش ترجمه

The crab Carcinus maenas as a suitable experimental model in ecotoxicology

Keywords: 6PGDH; 6-phosphogluconate dehydrogenase; AChE; acetylcholinesterase; AWP; apparent water permeability; BChE; butyrylcholinesterase; BP; benzopyrene; BPH; benzopyrene hydroxylase; BPMO; benzopyrene monoxygenase; BRI; Biomarker Response Index; CAT; catalase

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2014 سفارش ترجمه

Changes in antioxidant activity during the ripening of jujube (Ziziphus mauritiana Lamk)

Keywords: HPLC-ESI-MSMS (Q-Tof); high performance liquid chromatography-electrospray ionisation-tandem mass spectrometry (quadrupole-time-of-flight); LC-MS; liquid chromatography-mass spectrometry; GC-MS; gas chromatography-mass spectrometry; CJE; crude

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2014 سفارش ترجمه

Optimization of ultrasonic-assisted extraction and in vitro antioxidant activities of polysaccharides from Trametes orientalis

Keywords: BBD; Box-Behnken design; DEAE; diethylaminoethanol; DPPH; 1,1-diphenyl-2-picrylhydrazyl; EC50; half maximal effective concentration; EDTA; ethylenediaminetetraacetic acid; NBT; nitroblue tetrazolium; PTOP; purified T. orientalis polysaccharides; ROS; reac

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2014 سفارش ترجمه

Kinetic Analyses Reveal Potent and Early Blockade of Hepatitis C Virus Assembly by NS5A Inhibitors

Keywords: Antiviral Agent; Replication; Therapy; RNA-Dependent RNA Polymerase; BOC; boceprevir; CI; confidence interval; DAA; direct-acting antiviral; DCV; daclatasvir; EC50; 50% effective concentration; FFU; focus-forming unit; GLuc; Gaussia princeps luciferase; H

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2014 سفارش ترجمه

Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity

Keywords: BSP; 3-sulfopyruvate; CGH; comparative genomic hybridization; COOT; Crystallographic Object-Oriented Toolkit; DMEM; Dulbecco's Modified Eagle Medium; DTT; dithiothreitol; ECHO; echocardiogram; EC50; half maximal effective concentration; EEG; electroenceph

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2014 سفارش ترجمه

Differential Sensitivity of 5′UTR-NS5A Recombinants of Hepatitis C Virus Genotypes 1−6 to Protease and NS5A Inhibitors

Keywords: Drug Resistance; Cultures; Vaccine; PI; aa; amino acid; DAA; direct-acting antivirals; EC50; median effective concentration; FFU; focus-forming units; HCV; hepatitis C virus; IFN; interferon; nt; nucleotide; NS3P; NS3/NS4A protease; ORF; open reading fram

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2014 سفارش ترجمه

Cyanidin, a natural flavonoid, is an agonistic ligand for liver X receptor alpha and beta and reduces cellular lipid accumulation in macrophages and hepatocytes

Keywords: LXR; liver X receptor; LBD; ligand-binding domain; RXR; retinoid X receptor; KD; equilibrium dissociation constant; EC50; the half maximal effective concentration; SPR; surface plasmon resonance; TR-FRET; time-resolved fluorescent resonance energy transfe

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Exploring a potential palonosetron allosteric binding site in the 5-HT3 receptor

Keywords: 5-HT; 5-hydroxytryptamine (serotonin); EC50; concentration of agonist required for half-maximal response; HEK; human embryonic kidney; IC50; concentration of antagonist required for half-maximal inhibition; Kd; affinity constant; Serotonin receptor; Allos

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Characterization of a gap-junctional intercellular communication (GJIC) assay using cigarette smoke

Keywords: 2R4F; Kentucky reference cigarette code; CSC; cigarette smoke condensate; CV%; coefficient of variation; EC50; effective concentration 50% effect; GJIC; gap junctional intercellular communication; NNAL; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; NNK;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Honokiol: A non-adipogenic PPARγ agonist from nature

Keywords: AMPK; AMP-activated kinase; ANOVA; analysis of variance; ATCC; American type culture collection; BADGE; bisphenol A diglycidyl ether; BMP; bone morphogenic protein 4; BSA; bovine serum albumin; CMCNa; sodium carboxymethyl cellulose; DMEM; Dulbecco's modif

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Mechanism of dopamine D2 receptor-induced Ca2 + release in PC-12 cells

Keywords: DR; dopamine receptor; PLC; phospholipase C; CaMKII; calmodulin kinase II; IP3; inositol 1,4,5-trisphosphate; IP3R; inositol 1,4,5-trisphospate receptor; PKA; protein kinase A; GPCR; G protein coupled receptor; DMSO; dimethylsulfoxid; EC50; 50% effective

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

The time- and age-dependent effects of the juvenile hormone analog pesticide, pyriproxyfen on Daphnia magna reproduction

Keywords: pM; picomolar; EC50; half-maximal effect concentration; ng L−1; nano grams/Liter; USEPA; United States Environmental Protection Agency; Recovery; Endocrine disruptor; Environmental sex determination; Cladocera; Chronic toxicity;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Mechanisms of glucagon degradation at alkaline pH

Keywords: HPLC; high performance liquid chromatography; MS; mass spectrometry; RT; retention time; EGFP; enhanced green fluorescent protein; PKA; protein kinase A; MW; molecular weight; Da; Dalton; Fmoc; N-9-fluorenylmethoxycarbonyl; rp; reverse phase; CHO-K1; Chin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Effects of lack of pulsatility on pulmonary endothelial function in the Fontan circulation

Keywords: EC50; 50% of the maximal response; eNOS; endothelial nitric oxide synthase; Emax; maximal response; NO; nitric oxide; PA; pulmonary artery; PAP; pulmonary artery pressure; PVP; pulmonary vein pressure; PVR; pulmonary vascular resistance; SVC; superior ven

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity

Keywords: iPSC; induced pluripotent stem cell; BMC; benchmark concentration; DMSO; dimethyl sulfoxide; AUC; area under the curve; EC50; effective concentration at 50% of the maximum response; iPSC; Calcium flux; Cardiotoxicity; hERG; Phenotypic screening; Predictiv

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Investigating oxidative stress and inflammatory responses elicited by silver nanoparticles using high-throughput reporter genes in HepG2 cells: Effect of size, surface coating, and intracellular uptake

Keywords: Silver; Nanoparticles; Reporter genes; Stress response; NRF2; Oxidative stress; AgNO3; silver nitrate; Ag NPs; silver nanoparticles; Ag+; silver ion; AP1; activator protein 1; ARE; antioxidant response element; BSO; l-buthionine (S,R)-sulfoximine; CeO2; c

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Human T47D-ERβ breast cancer cells with tetracycline-dependent ERβ expression reflect ERα/ERβ ratios in rat and human breast tissue

Keywords: BPH; benign prostatic hyperplasia; cDNA; complementary deoxyribonucleic acid; DCC-FCS; dextran-coated charcoal-treated fetal calf serum; DL; detection limit; DNA; deoxyribonucleic acid; dNTP; deoxynucleotide triphosphate; DMEM; Dulbecco's modified Eagle

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Cytotoxic effects of amphetamine mixtures in primary hepatocytes are severely aggravated under hyperthermic conditions

Keywords: D-Amp; D-amphetamine; CA; concentration addition; CI; confidence intervals; EC50; concentration producing 50% of the maximal effect in the MTT assay; FBS; fetal bovine serum; IA; independent action; MDMA; 3,4-Methylenedioxymethamphetamine, ecstasy; METH;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

The E-screen test and the MELN gene-reporter assay used for determination of estrogenic activity in fruits and vegetables in relation to pesticide residues

Keywords: COU; coumestrol; DMEM; Dulbecco's Modified Eagle Medium; E2; 17b-estradiol; EC50; effective concentration 50; EDCs; endocrine disruptor compounds; EEF; estradiol equivalency factor; EEQ; estradiol equivalency quantity; EFSA; European food safety authori

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Metalloprotein-based MRI probes

Keywords: BBB; blood-brain barrier; BOLD; blood oxygen level dependent; CNS; central nervous system; BM3h; cytochrome P450 BM3 heme domain; EC50; effective concentration midpoint; T1e; electronic relaxation time; S; electron spin number; Ft; ferritin; fMRI; funct

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

(−)-Reboxetine inhibits muscle nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites

Keywords: AChR; nicotinic acetylcholine receptor; NSRI; norepinephrine selective reuptake inhibitor; TCAs; tricyclic antidepressants; NCA; non-competitive antagonist; (−)-reboxetine; (−)-R,R-([2-[α[2-ethoxyphenoxy]benzyl]-morpholine); PCP; phencyclidine; [3H]T

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Hanging drop: An in vitro air toxic exposure model using human lung cells in 2D and 3D structures

Keywords: HD; hanging drop; VOC; volatile organic compound; EC50; effect concentration causing 50% of maximum effect; ECM; extracellular matrix; VOA vials; volatile organic analysis vials; SOM; supplementary online materials; IEC; internal effect concentration; QSA

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents

Keywords: lipid raft; receptor; Kv7/M current; modulation; specificity; B2R; bradykinin receptor; BK; bradykinin; DRG; dorsal root ganglion; EC50; 50% effective concentration; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol tetraacetic acid; GPCR; G pr

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction

Keywords: IN; HIV-1 integrase; LEDGF/p75; lens epithelium-derived growth factor/p75; HBD; hydrogen bond donor; HBA; hydrogen bond acceptor; IC50; 50% inhibitory concentration; EC50; 50% effective concentration; CC50; 50% cytotoxic concentration; CCID50; cell cultur

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Improved tolerance to salt and water stress in Drosophila melanogaster cells conferred by late embryogenesis abundant protein

Keywords: DW; dry weight; EC50; effector concentration that yields half-maximal response; LEA; late embryogenesis abundant; OMM; outer mitochondrial membrane; ROX; residual oxygen consumption; Mitochondria; Water stress; Bioenergetics; Cellular respirometry; Cryopr

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Novel 2-(substituted benzyl)quinuclidines inhibit human α7 and α4β2 nicotinic receptors by different mechanisms

Keywords: nAChR; nicotinic acetylcholine receptor; ACh; acetylcholine; CCh; carbamylcholine; [3H]MLA; [3H]methyllycaconitine; RT; room temperature; IC50; ligand concentration that produces 50% inhibition (of binding or of agonist activation); Ki; inhibition constan

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1

Keywords: ERK; extracellular signal-regulated kinase; TSC-2; tuberous sclerosis 2 protein; mTOR; mammalian target of rapamycin; IRS; insulin receptor substrate; PI3K; phosphoinositide-3-kinase; AKT; protein kinase B; MAPK; mitogen-activated protein kinase; FOXO1; f

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه