Targeting the p53 Pathway
Keywords: p53; Mdm-2; FAK; Survival; Apoptosis;
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Inhibition of Lymphangiogenesis and Angiogenesis in Breast Tumor Xenografts and Lymph Nodes by a Peptide Derived from Transmembrane Protein 45A
Keywords: BVD; blood vessel density; FAK; focal adhesion kinase; HSP27; heat shock protein 27; HUVECs; human umbilical vein endothelial cells; LECs; lymphatic endothelial cells; LN; lymph node; LVD; lymphatic vessel density; MECs; microvascular endothelial cells; N
Pro-Angiogenic Activity of TLRs and NLRs: A Novel Link Between Gut Microbiota and Intestinal Angiogenesis
Keywords: Angiogenesis; IBD; TLR; NLR; bFGF; basic fibroblast growth factor; DMEM; Dulbecco's minimal essential medium; FAK; focal adhesion kinase; FBS; fetal bovine serum; GFP; green fluorescent protein; HIF; human intestinal fibroblast; HIMEC; human intestinal mi
Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells
Keywords: Angiogenesis; Cafestol; FAK; Akt; Nitric oxide
Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases
Keywords: Kinase; JAK2; FAK; Inhibitors;
Blockade of VEGF-A suppresses tumor growth via inhibition of autocrine signaling through FAK and AKT
Keywords: VEGF; FAK; AKT; Apoptosis; Autocrine signalingFAK, focal adhesion kinase; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; HIF-1α, hypoxic inducible factor 1α; siRNA, small interfering RNA; shRNA, small hairpin RNA; VEGF, vascular endothelial growth facto
Laminin peptide YIGSR induces collagen synthesis in Hs27 human dermal fibroblasts
Keywords: Collagen; Dermal fibroblast; ERK; FAK; Pyk2; Wrinkle; YIGSR
Cortactin and focal adhesion kinase as predictors of cancer risk in patients with premalignant oral epithelial lesions
Keywords: Oral cavity; Dysplasia; Oral squamous cell carcinoma; Cortactin; FAK; Immunohistochemistry; Cancer risk;
The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis
Keywords: GPCR; G protein-coupled receptor; GRK; GPCR kinase; GIT; GRK-interacting protein; ARF-GAPs; ADP-ribosylation factor GTPase-activating proteins; GEF; guanine nucleotide exchange factor; MSC; mesenchymal stem cell; qCT; quantitative micro-computed tomograph
Impaired c-src activation and motility defects in PEA3-null fibroblasts
Keywords: c-src; PEA3; Adhesion complex; p130Cas; Paxillin; FAK
Caffeoylserotonin suppresses THP-1 monocyte adhesion and migration via inhibition of the integrin β1/FAK/Akt signalling pathway
Keywords: Caffeoylserotonin; Monocyte; Adhesion; Migration; Akt; FAK
Effects of alcohol on pericardial adhesion formation in hypercholesterolemic swine
Keywords: 32; 38.2; 40.3; ANOVA; analysis of variance; CRP; C-reactive protein; ECM; extracellular matrix; FAK; focal adhesion kinase; HCC; high-cholesterol control; HCV; high-cholesterol vodka; HCW; high-cholesterol wine; Int α5; integrin alpha-5; Int β1; integr
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors
Keywords: PYK2; FAK; DFG-out; Osteoporosis; Kinase inhibitor; BIRB-796;
Tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R8ERY prepared via Click Chemistry: Synthesis and biological evaluation
Keywords: CuAAC; copper catalyzed azide-alkyne cycloaddition; FAK; focal adhesion kinase; FBS; fetal bovine serum; GALT; gut-associated lymphoid tissues; GnHCl; guanidine hydrochloride; GVHD; graft-versus-host disease; HBSS; Hank's buffered salt solution; HMP; 4-
Cbl-b-dependent degradation of FLIPL is involved in ATO-induced autophagy in leukemic K562 and gastric cancer cells
Keywords: ATO; arsenic trioxide; CQ; chlorochine; FLIPL; FLICE-like inhibitory protein long; FLIPS; FLICE-like inhibitory protein short; Cbl-b; casitas B-lineage lymphoma-b; TNF; tumor necrosis factor; FAK; focal adhesion kinase; Arsenic trioxide; Autophagy; FLIPL;
Enhanced radiosensitivity of head and neck squamous cell carcinoma cells by β1 integrin inhibition
Keywords: Ionizing radiation; Extracellular matrix; β1 integrin; FAK; Head and neck cancer
Targeting FAK Radiosensitizes 3-Dimensional Grown Human HNSCC Cells Through Reduced Akt1 and MEK1/2 Signaling
Keywords: Ionizing radiation; Focal adhesion kinase; FAK; MEK1/2; Three-dimensional cell culture; Squamous cell carcinoma;
Anti-angiogenic effects of thioridazine involving the FAK-mTOR pathway
Keywords: HUVECs; human umbilical vein endothelial cells; Thioridazine; 10-[2-(1-methyl-2-piperidyl) ethyl]-2-methylthiophenothiazine; FAK; focal adhesion kinase; mTOR; the mammalian target of rapamycin; VEGF; vascular endothelial growth factor;
Focal adhesion kinase negatively regulates neuronal insulin resistance
Keywords: FAK; Insulin resistance; Neuronal cells
Mechanisms of human smooth muscle cell proliferation and transplant vasculopathy induced by HLA class I antibodies: In vitro and in vivo studies
Keywords: TV; transplant vasculopathy; HLA; human leukocyte antigen; SMC; smooth muscle cells; EC; endothelial cells; MMP; matrix metalloproteinases; MMP-2; matrix metalloproteinase 2; FAK; focal adhesion kinase; mTOR; mammalian target of rapamycin; PI3K; phosphati
Roles of αvβ5, FAK and MerTK in oxidative stress inhibition of RPE cell phagocytosis
Keywords: cathepsin D; αVβ5; FAK; MerTK; oxidative stress; phagocytosis
NNK promotes migration and invasion of lung cancer cells through activation of c-Src/PKCι/FAK loop
Keywords: Lung cancer; Migration; Invasion; PKC iota; c-Src; FAK
Focal Adhesion Kinase Signaling is Necessary for the Cyclosporin A-Enhanced Migration and Invasion of Human Trophoblast Cells
Keywords: Cyclosporine A; FAK; Src; Migration and invasion; Trophoblast cell;
Focal adhesion kinase governs cardiac concentric hypertrophic growth by activating the AKT and mTOR pathways
Keywords: FAK; focal adhesion kinase; FAK-Tg; cardiac-specific FAK transgenic mice model; FAKi; pharmacological FAK inhibitor (PF 573228); RP; rapamycin; TAC; thoracic aortic constriction; Cardiac myocytes; Cardiac failure; Mechanotransduction; Signal transduction;
Astrocyte-derived GDNF is a potent inhibitor of microglial activation
Keywords: ACM; astrocytes conditioned media; BDNF; brain-derived neurotrophic factor; CDNF; cerebral dopamine neurotrophic factor; ERK; extracellular signal-regulated kinase; FAK; focal adhesion kinase; GDNF; glial cell line-derived neurotrophic factor; IL; interle
CommentaryExtraneuronal activities and regulatory mechanisms of the atypical cyclin-dependent kinase Cdk5
Keywords: APE1; apurinic-apyrimidinic endonuclease 1; Cdk; cyclin-dependent kinase; Cdk5R1 or p35; Cdk5 regulatory protein R1; Cdk5R2 or p39; Cdk5 regulatory protein R2; EPRS; glutamyl-prolyl tRNA synthetase; E-Syt1; extended synaptotagmin-1; FAK; focal adhesion ki
Reconstitution of laminin-111 biological activity using multiple peptide coupled to chitosan scaffolds
Keywords: Cell adhesion; Chitin/chitosan; ECM (extracellular matrix); Integrin; Peptide; Scaffold; ECM; Extracellular matrix; BME; Basement membrane extract; EHS; Engelbreth-Holm-Swarm; Fmoc; 9-Fluorenylmethoxycarbonyl; MBS; N-(m-maleimidobenzoyloxy) succinimide; D
EBP50 promotes focal adhesion turnover and vascular smooth muscle cells migration
Keywords: EBP50; ezrin-radixin-moesin-binding Phosphoprotein 50; EGF; epidermal growth factor; EGFR; EGF receptor; ERM; ezrin-radixin-moesin; FA; focal adhesion; FAK; focal adhesion kinase; FBS; fetal bovine serum; GFP; green fluorescent protein; KO; knocko
JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin
Keywords: JNK, c-jun N-terminal kinase; FAK, focal adhesion kinase; EGF, epithelial growth factor; THCE, SV40-immortalized human corneal epithelial; RNAi, RNA interference.Cell migration; JNK; Paxillin; FAK
Spatiotemporal regulation of Src and its substrates at invadosomes
Keywords: Src; Invasion; Invadosome; Invadopodia; Podosome; Rosette; Rho; Cdc42; FAK; Cortactin; Mabp1; ROS; MT1-MMP
Depletion of protein kinase N3 (PKN3) impairs actin and adherens junctions dynamics and attenuates endothelial cell activation
Keywords: ICAM-1; FAK; Atu027; TNF-α activated endothelium; Inflammation
Concepts of metastasis in flux: The stromal progression model
Keywords: BMDC; bone marrow-derived cell; CAF; carcinoma-associated fibroblast; CGH; comparative genomic hybridization; CSC; cancer stem cell; CTC; circulating tumor cell; DTC; disseminated tumor cells; ECM; extracellular matrix; EMT; epithelial-mesenchymal trans
Targeted subendothelial matrix oxidation by myeloperoxidase triggers myosin II-dependent de-adhesion and alters signaling in endothelial cells
Keywords: BAH; 4-aminobenzoic acid hydrazide; PP2; 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine; ECs; bovine aortic endothelial cells; FAK; focal adhesion kinase; HBSS; Hank's balanced salt solution; HOCl; hypochlorous acid; HOSCN; hypoth
Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid
Keywords: BPs; bisphosphonates; ZOL; zoledronate; ECM; extracellular matrix; HA; hyaluronan; MMP; matrix metalloproteinase; PG; proteoglycan; MT-MMP; membrane-type MMP; TIMPs; tissue inhibitors of MMPs; COL I; collagen I; COL II; collagen II; COL-IV; collagen IV; F
Deoxyelephantopin impedes mammary adenocarcinoma cell motility by inhibiting calpain-mediated adhesion dynamics and inducing reactive oxygen species and aggresome formation
Keywords: DET; deoxyelephantopin; PTX; paclitaxel; EGF; epithelial growth factor; EGFR; epithelial growth factor receptor; ROS; reactive oxygen species; FAK; focal adhesion kinase; ER; endoplasmic reticulum; JNK; c-Jun N-terminal kinase; MG132; carbobenzoxyl-l-leuc
Integrin-Associated CD151 Drives ErbB2-Evoked Mammary Tumor Onset and Metastasis
Keywords: ER; estrogen receptor; cPKC; conventional PKC; EGFR; epidermal growth factor receptor; ErbB2; epidermal growth factor receptor 2; LB; laminin binding; FAK; focal adhesion kinase; IHC; immunohistochemistry; ERK; extracellular signal-regulated kinase; MMTV;
Inflammation-related gene expression by lipid oxidation-derived products in the progression of atherosclerosis
Keywords: 7α-OH; 7α-hydroxycholesterol; 7-K; 7-ketocholesterol; 9-ONC; 9-oxononanoyl cholesterol; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; α-EPOX; 5α,6α-epoxycholesterol; AP-1; activator protein-1; ARE; antioxidant-responsive element; ATF; activating trans
Associate editor: M.G. BelvisiMatrikines and the lungs
Keywords: aa; amino acid; ADAM; a disintegrin and metalloproteinase; APP; amyloid beta precursor; CXCR; C-X-C motif chemokine receptor; ECM; Extracellular matrix; ED; extra domains; EGF; epidermal growth factor; ERK; extracellular signal-regulated kinase; FAK; foca
Activation of Toll-like receptors induces macrophage migration via the iNOS/Src/FAK pathway
Keywords: FAK; iNOS; macrophage migration; Src; Toll-like receptors;
Extracellular ATP stimulates epithelial cell motility through Pyk2-mediated activation of the EGF receptor
Keywords: EGFR; epidermal growth factor receptor; SFK; Src family kinase; FAK; focal adhesion kinase; Pyk2; proline-rich tyrosine kinase 2; HCLE; human corneal limbal epithelial; SKI; Src Kinase Inhibitor-I; siRNA; small interfering RNA; PRNK; Pyk2-related non-kina
Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis
Keywords: FAK; Cell migration; Angiogenesis; Signal transduction; Cancer
Panax notoginseng saponins inhibit Zymosan A induced atherosclerosis by suppressing integrin expression, FAK activation and NF-κB translocation
Keywords: Panax notoginseng saponins; Atherogenesis; Integrin; FAK; NF-κB;
Focal adhesion kinase signaling pathway is involved in mechanotransduction in MG-63 Cells
Keywords: Osteoblast; Mechanotransduction; FAK; Mechanical loading
Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination
Keywords: TNF-α; tumor necrosis factor alpha; HcrtR2; Hypocretin receptor 2; cIAP; cellular inhibitor of apoptosis protein; FAK; focal adhesion kinase; G3PDH; glyceraldehyde 3-phosphate dehydrogenase; RT-PCR; reverse transcriptase polymerase chain reaction; MSCV v
CTGF inhibits cell motility and COX-2 expression in oral cancer cells
Keywords: CTGF; Migration; Oral cancer; FAK; Integrin
Changes in cell migration of mesenchymal cells during osteogenic differentiation
Keywords: Mesenchymal mode; BMP; Y-27632; Osteogenic differentiation; ST2; ROCK; Rho-associated kinase; FAK; focal adhesion kinase; OPN; osteopontin; PTHR; parathyroid hormone receptor; Osx; osterix; OCN; osteocalcin; MLC; myosin light chain;
Rho GTPases as regulators of morphological neuroplasticity
Keywords: C3; Clostridium botulinum ribosyltransferase; cAMP; cyclic adenosine monophosphate; Cdc42; cell division control protein 42 homolog; CRIB; Cdc42/Rac interactive binding; DRG; dorsal root ganglia; ERK; extracellular signal-regulated kinase; FAK; focal adhe
Lumican regulates osteosarcoma cell adhesion by modulating TGFβ2 activity
Keywords: SLRP; small leucine rich proteoglycans; FN; fibronectin; FAK; focal adhesion kinase; TGF-β2t; ransforming growth factor β2; Lumican; Osteosarcoma cell adhesion; TGF-β2; pSmad; β1 integrin; FAK;
Promyogenic function of Integrin/FAK signaling is mediated by Cdo, Cdc42 and MyoD
Keywords: Cell adhesion; FAK; Integrin; Cdo; Cdc42; MyoD;
Cadmium inhibits motility factor-dependent migration of human trophoblast cells
Keywords: CI-1; caspase inhibitor-1; CM; complete media; ET-1; endothelin-1; EVT; extravillous trophoblast; FAK; focal adhesion kinase; IGF-II; insulin like growth factor-II; IGFBP-1; IGF binding protein-1; IUGR; intrauterine growth retardation; MAPK; mitogen activ