Keywords: Vemurafenib; LC-MS/MS; Plasma; GLP; Validation;
مقالات ISI (ترجمه نشده)
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Keywords: CI; confidence interval; CP; cyclophosphamide; GLP; Good Laboratory Practices; HPLC; high performance liquid chromatography; HPTLC; high performance thin layer chromatography; ICH; International Conference on Harmonization; l.c.; label claim; LoD; limit o
Keywords: 3T3 NRU PT; 3T3 neutral red uptake phototoxicity test; 8-MOP; 8-methoxypsoralen; CV; coefficient of variation; ECVAM; Europe Center for the Validation of Alternative Methods; GLP; Good Laboratory Practice; ICCVAM; Interagency Coordinating Committee on the
Keywords: ARA; arachidonic acid; DHA; docosahexaenoic acid; GLP; good laboratory practices; GRAS; generally recognized as safe; LC-PUFA; long-chain polyunsaturated fatty acids; NOAEL; no observed adverse effect level; RBC; red blood cells; wt%; weight percent; Doco
Keywords: Microalgae; Fermentation; Oleic-rich oil; Genotoxic; Mutagenic; Subchronic toxicity; 2-AA; 2-aminoanthracene; AAALAC; Association for Assessment and Accreditation of Laboratory Animal Care International; ANOVA; Analysis of Variance; AOAC; Association of A
Keywords: Reproductive toxicology; GLP; ICH; SEND; Validation; CT;
Keywords: Senolytic; an agent that targets senescent cells; ADME; absorption, distribution, metabolism, and excretion of a drug; SASP; senescence-associated secretory phenotype; mTOR; mammalian target of rapamycin; JAK; Janus-activated kinase; GLP; good laboratory
Keywords: AGEs; advanced glycation endproducts; BMD; bone mineral density; CAH; congenital adrenal hyperplasia; DM; diabetes mellitus; DPP-4; dipeptydil petptidase-4; DXA; dual-energy X-ray absorptiometry; FRAX; fracture risk assessment tool; FSH; follicle stimulat
Keywords: ANSES; French Agency for Food, Environmental and Occupational Health & Safety; BfR; Bundesinstitut für Risikobewertung, German Federal Institute for Risk Assessment; BPA; bisphenol A; EAC; endocrine active compound; EDC; endocrine disrupting chemical; EF
Keywords: ADC; antibody-drug conjugate; ADME; absorption, distribution, metabolism and elimination; EFD; embryofetal development; ELISA; enzyme-linked immunosorbent assay; FIH; first-in-human; GLP; Good Laboratory Practice; hERG; human ether-Ã -go-go related gene;
Keywords: AAALAC; Association for Assessment and Accreditation of Laboratory Animal Care International; ANOVA; Analysis of variance; FEMA; Flavor and Extract Manufacturers Association; GLP; Good Laboratory Practices; ILS; Integrated Laboratory Systems; NOAEL; No ob
Keywords: 3Rs; replacement, refinement and reduction of animals in research; ACSA; Agricultural Chemicals Safety Assessment; ADA; anti-drug antibody; CNS; central nervous system; DBS; dried blood spot; DART; developmental and reproductive toxicity; DRF; dose range
Keywords: 03F45; 03B45; 54A10; 54G12Provability logic; Scattered spaces; GLP
Preparation and characterization of yeast cell wall beta-glucan encapsulated humic acid nanoparticles as an enhanced aflatoxin B1 binder
Keywords: YCWP; yeast cell wall particle; YGP or GP; yeast glucan particle; GLP; glucan lipid particle; GMLP; glucan mannan lipid particle; GCP; glucan chitin particle; GCMP; glucan chitin mannan particle; GCLP; glucan chitin lipid particle; GCLMP; glucan chitin li
28-day inhalation toxicity of 3-methoxybutyl chloroformate in rats
Keywords: ANOVA; analysis of variance; CT; computed tomography; EDTA; ethylenediamine tetraacetic acid; GHS; Globally Harmonized System of Classification and Labelling of Chemicals; GLP; Good Laboratory Practice; HCT; hematocrit; HGB; hemoglobin concentration; MCH;
Analytical performance of a commercial multiplex Luminex-based cytokine panel in the rat
Keywords: Biomarker; Cytokine; GLP; Multiplex; Rat; Validation;
Novel approaches in the treatment of diabetic cardiomyopathy
Keywords: ACE; angiotensin convertase enzyme; ACEi; angiotensin convertase enzyme inhibitor; ADP; adenosine di phosphate; AGE; advanced glycation end products; AM; adrenomedullin; AMP; adenosine mono phosphate; ARB; angiotensin receptor blocker; ATP; adenosine tri
Worsening Heart Failure During the Use of DPP-4 Inhibitors
Keywords: diabetes; DPP-4 inhibitors; heart failure risk; saxagliptin; sitagliptin; AMP; adenosine monophosphate; DPP; dipeptidyl peptidase; GLP; glucagon-like peptide; SDF; stromal cell-derived factor; SGLT2; sodium-glucose transporter 2;
Assessing the safety of an Ephedrae Herba aqueous extract in rats: A repeat dose toxicity study
Keywords: Repeated dose toxicity; Safety assessment; Ephedrae Herba; F344 rats; NOAEL; ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; bw; body weight; BUN; blood urea nitrogen; CREA; creatinine; GLU; glucose; LUC; large u
Discovery of 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one, an orally active multi-target agent for the treatment of diabetic nephropathy
Keywords: ACR; albumin-to-creatinine ratio; AUC0-t; area under the curve; BuOH; n-butanol; BUN; blood urea nitrogen; Cmax; peak concentration; C13-NMR; C13-nuclear magnetic resonance; CCr; creatinine clearance rate; CCR2; CCchemkin receptor 2; CDCl3; Deuterotrichlo
Extractability-mediated stability bias and hematocrit impact: High extraction recovery is critical to feasibility of volumetric adsorptive microsampling (VAMS) in regulated bioanalysis
Keywords: VAMS; volumetric absorptive microsampling; Ht; hematocrit; LLE; liquid-liquid extraction; GLP; good laboratory practice; LC-MS/MS; liquid chromatography coupled with triple quadrupole mass spectrometry; LLOQ; lower limit of quantification; ULOQ; upper
Effects of Vildagliptin on Ventricular Function in Patients With Type 2 Diabetes Mellitus and Heart Failure
Keywords: diabetes; heart failure; BNP; B-type natriuretic peptide; DPP; dipeptidyl peptidase; GLP; glucagon-like peptide; HFrEF; heart failure and reduced ejection fraction; NYHA; New York Heart Association;
Microdialysis combined with RRLC-MS/MS for the pharmacokinetics of two major alkaloids of Bi qi capsule and the potential roles of P-gp and BCRP on their penetration
Keywords: BQC; Bi qi capsule; BBB; blood-brain barrier; RRLC-MS/MS; rapid resolution liquid chromatography -tandem mass spectrometry; P-gp; P-glycoprotein; BCRP; breast cancer resistance protein; CNS; central nervous system; CSF; cerebrospinal fluid; LLOQ; lower li
Genetic Variants in SGLT1, Glucose Tolerance, and Cardiometabolic Risk
Keywords: glucose tolerance; Mendelian randomization; SGLT1; BP; blood pressure; CI; confidence interval; DM; diabetes mellitus; FFQ; food frequency questionnaire; GGM; glucose-galactose malabsorption; GLP; glucagon-like peptide; HF; heart failure; HGSC; Human Geno
Genotoxicity evaluation of the naturally-derived food colorant, gardenia blue, and its precursor, genipin
Keywords: Genotoxicity; Gardenia blue; Genipin; DNA damage; Food colorant; DNA crosslinking; DMSO; (dimethyl sulfoxide); EFSA; European Food Safety Authority; (EMS); ethyl methanesulfonate; FDA; US Food and Drug Administration; GLP; Good Laboratory Practice; MN; mi
Quantitative evaluation of the matrix effect in bioanalytical methods based on LC-MS: A comparison of two approaches
Keywords: AAPS; American Association of Pharmaceutical Scientists; CV(%); coefficient of variation; EMA; European Medicines Agency; FDA; U.S. Food and Drug Administration; GLP; good laboratory practice; IS; internal standard; IS-norm; internal standard normalized;
In vitro secondary pharmacological profiling: An IQ-DruSafe industry survey on current practices
Keywords: AUC; Area Under the Curve; CRO; Contract Research Organization; CTA; Clinical Trial Authorization; GLP; Good Laboratory Practice; hERG; human ether-a-go-go-related gene; ICH; International Conference on Harmonization; IND; Investigational New Drug; IQ; In
The Gaussian-Lorentzian Sum, Product, and Convolution (Voigt) functions in the context of peak fitting X-ray photoelectron spectroscopy (XPS) narrow scans
Keywords: XPS; GLS; GLP; Voigt function; Gaussian function; Lorentzian function;
Transcriptomic analysis of Momordica charantia polysaccharide on streptozotocin-induced diabetic rats
Keywords: M. charantia; Momordica charantia; RNA-seq; RNA sequencing; T2DM; Type 2 diabetes mellitus; IR; insulin resistance; PPAR; peroxisome proliferator-activated receptor; FBG; fasting blood glucose; G6Pase; glucose-6-phosphatase; PEPCK; phosphoenol pyruvate ca
Bile salt enhancers for inhalation: Correlation between in vitro and in vivo lung effects
Keywords: ADSA; axisymmetric drop shape analysis; ATP; adenosine triphosphate; APIs; active pharmaceutical ingredients; BPM; breaths per minute; bw; body weight; CDS; constrained drop surfactometer; CMC; critical micelle concentration; DMSO; dimethylsulfoxid; GLP;
A 14-day repeated-dose oral toxicological evaluation of an isothiocyanate-enriched hydro-alcoholic extract from Moringa oleifera Lam. seeds in rats
Keywords: ANOVA; analysis of variance; GLP; good laboratory practice; ITC; isothiocyanate; MIC-1; moringa isothiocyanate-1; MICs; moringa isothiocyanates; MSE; moringa seed extract; NF-κB; nuclear factor kappa B; NO; nitric oxide; NOAEL; no observed adverse effect
High PD-L1/CD86 MFI ratio and IL-10 secretion characterize human regulatory dendritic cells generated for clinical testing in organ transplantation
Keywords: DC(s); dendritic cell(s); DCreg; regulatory DC; GLP; good manufacturing practice; imDC; immature DC; matDC; mature DC; PCC; pro-inflammatory cytokine cocktail; PD-(L)1; programed death (ligand)1; Human; Dendritic cells; Immune regulation; Cell therapy;
In vitro and in vivo safety studies of cinnamon extract (Cinnamomum cassia) on general and genetic toxicology
Keywords: Cinnamomum cassia; Cinnamon; Toxicity; Subchronic; Genotoxicity; GLP; Good Laboratory Practice; OECD; Organization for Economic Co-operation and Development; WBC; white blood cell; RBC; red blood cell; HGB; hemoglobin; HCT; hematocrit; PLT; platelet; MCV;
Safety evaluation of a mixture of the human-identical milk oligosaccharides 2â²-fucosyllactose and difucosyllactose
Keywords: 2â²-fucosyllactose; Difucosyllactose; Lactodifucotetraose; Human-identical milk oligosaccharide; Infant formula; Safety; 2-AA; 2-aminoanthracene; 2â²-FL; 2â²-fucosyllactose; 2â²-FL/DFL; 2â²-fucosyllactose/difucosyllactose mixture; 2-NF; 2-nitroflouri
Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential
Keywords: 2AA; 2-aminoanthracene; 9AA; 9-aminoacridine hydrochloride monohydrate; ADI; acceptable daily intake; AF-2; 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide; DMSO; dimethyl sulfoxide; EFSA; European Food Safety Authority; FAO; Food and Agriculture Organization
Lack of genotoxicity in vivo for food color additive Tartrazine
Keywords: Food color; Tartrazine; FD&C Yellow No. 5; E102; INS 102; Genotoxicity; CP; Cyclophosphamide; EFSA; European Food Safety Authority; EU; European Union; FD&C; Food, Drug, and Cosmetic; GLP; Good Laboratory Practices; INS; International Numbering System; JE
Lack of genotoxicity in vivo for food color additive Allura Red AC
Keywords: Food color; Allura Red AC; FD&C Red no. 40; E129; INS 129; Genotoxicity; CP; Cyclophosphamide; EUEFSA; European Food Safety Authority; EU; European Union; FD&C; Food, Drug, and Cosmetic; GLP; Good Laboratory Practices; INS; International Numbering System;
Identification of appropriate QTc formula in beagle dogs for nonclinical safety assessment
Keywords: Beagle dogs; Electrocardiogram; Heart rate; QT correction formula; Preclinical assessment; AAALAC; Association for Assessment and Accreditation of Laboratory Animal Care; ECG; Electrocardiogram; GLP; Good Laboratory Practice; HR; Heart Rate; ICH; Internat
Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine
Keywords: ACN; acetonitrile; BER; base excision repair; C.V.; coefficient of variation; DMSO; dimethylsulfoxide; DSB; double strand break; EMA; European Medicine Agency; FDA; Food and Drug Administration; GLP; Good Laboratory Practice; HRR; homologous recombination
Absence of subchronic oral toxicity and genotoxicity of rice koji with Aspergillus terreus
Keywords: Aspergillus terreus; Koji; Fermented food; Functional food; Toxicity; Subchronic; Genotoxicity; NOAEL; no-observed-adverse-effect level; OECD; Organization for Economic Co-operation and Development; GLP; Good Laboratory Practice; WBC; white blood cell; RB
Framework for the quality assurance of 'omics technologies considering GLP requirements
Keywords: Good laboratory practice (GLP); Standard operating procedure; Independent quality assurance; Documentation; Data storage; Reproducibility; Raw data definition; Software validation; Quality assurance inspection; ECETOC; European Centre for Ecotoxicology an
An FDA oncology analysis of CD3 bispecific constructs and first-in-human dose selection
Keywords: CD3 bispecific; MABEL; First-in-human dose; Oncology drug development; FIH; first-in-human; CRA; cytokine release assay; CRS; cytokine release syndrome; GLP; good laboratory practice; HHD; highest human dose; HNSTD; highest non-severely toxic dose; IB; In
Structure-activity relationship studies of G9a-like protein (GLP) inhibitors
Keywords: GLP; G9a; Inhibitor; Quinazoline; Quinoline;
Pharmacokinetic and screening studies of the interaction between mononuclear phagocyte system and nanoparticle formulations and colloid forming drugs
Keywords: ABC; accelerated blood clearance; ANC; absolute neutrophil count; BLQ; below limit of quantification; CL; clearance; DC; dendritic cells; DHR; dihydrorhodamine; FCM; flow cytometry; fMLP; N-formyl-methionine-leucine-phenylalanine; GLP; Good laboratory Pra
Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study
Keywords: Furan; Tumorigenicity; Cholangiocarcinoma; Cholangiofibrosis; Rats; Bioassay; BMD; benchmark dose; BMDL; lower limit of benchmark dose; BW; body weight; FDA; Food and Drug Administration; GLP; Good Laboratory Practice; MOE; margin of exposure; NCTR; Natio
Impact of the Cu(II) ions on the chemical and biological properties of goserelin - coordination pattern, DNA degradation, oxidative reactivity and in vitro cytotoxicity
Keywords: A549; human lung adenocarcinoma cell line; cAMP; cyclic adenosine monophosphate; CT26; mouse colon carcinoma cell line; DFT; Density Functional Theory; DMEM; Dulbecco's Modified Eagle Medium; FBS; fetal bovine serum; FDA; fluorescein diacetate; Gos; goser
Genomic organization and structural diversity of germin-like protein coding genes in foxtail millet (Setaria italica L.)
Keywords: bp; base pairs; CARES; cis-acting regulatory elements; CDS; coding sequence; GER; germins; GLP; germin-like proteins; GO; gene ontology; HMM; hidden Markov Model; MYA; million years ago; OXO; oxalate oxidases; pI; iso-electric point; RT-PCR; Reverse trans
The challenge of the application of 'omics technologies in chemicals risk assessment: Background and outlook
Keywords: Omics; Transcriptomics; Weight-of-evidence; Registration, Evaluation, Authorisation, and Restriction (REACH); Plant protection products; Regulatory toxicology; Hazard assessment; Test method validation; Test method standardisation; AOP; Adverse outcome pa
A novel hybrid solid-like fluid-like (SLFL) method for the simulation of dry granular flows
Keywords: SPH; smoothed particle hydrodynamics; GR-SPH; Ghost removed SPH; TCF; truncation correction factor; GLP; glued liner particle; HLP; hung liner particles; NDT; non-dimensional time; NDV; non-dimensional velocity; Solid-like; Fluid-like; Granular flow; Smoo
The effects of RAMPs upon cell signalling
Keywords: Receptor activity modifying protein; G protein-coupled receptor; Signalling; Trafficking; Coupling; AM; adrenomedullin; AMY; amylin; CaSR; calcium-sensing receptor; CGRP; calcitonin gene-related peptide; CHO; chinese hamster ovary; CLR; calcitonin recepto