Clinical assessment of HNF1A and GCK variants and identification of a novel mutation causing MODY2
Keywords: گلوکوکیناز; MODY; Glucokinase; HNF1A protein
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Characterization and crystal structure of the thermophilic ROK hexokinase from Thermus thermophilus
Keywords: گلوکوکیناز; Hexokinase; Glucokinase; ROK family; Thermus thermophilus; Crystal structure
Knockout of SOD1 alters murine hepatic glycolysis, gluconeogenesis, and lipogenesis
Keywords: گلوکوکیناز; AMPK; AMP-activated protein kinase; GK; glucokinase; GPX1; Se-glutathione peroxidase 1; JNK2; c-Jun NH2-terminal kinase; MAPK; mitogen-activated protein kinase; MS; metabolic syndrome; NEFA; nonesterified fatty acid; PEPCK; phosphoenolpyruvate carboxykina
Effects of brown alga, Ecklonia cava on glucose and lipid metabolism in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus
Keywords: گلوکوکیناز; IPGTT; intraperitoneal glucose tolerance test; GK; glucokinase; G6Pase; glucose-6-phosphatase; PEPCK; phosphoenolpyruvate carboxykinase; SOD; superoxide dismutase; CAT; catalase; Anti-diabetic; C57BL/KsJ-db/db mice; Eckloniacava; Glucose regulating enzyme
The glucokinase activator AZD6370 decreases fasting and postprandial glucose in type 2 diabetes mellitus patients with effects influenced by dosing regimen and food
Keywords: گلوکوکیناز; Glucokinase activator; Pharmacokinetics; Pharmacodynamics; Glucokinase; Type 2 diabetes mellitus
Bio-informatics based analysis of genes implicated in alcohol mediated liver injury
Keywords: گلوکوکیناز; (ATF4); Activating transcription factor 4; (ACOX); Acyl-CoA oxidase; (ADIPOR); Adiponectin; (ADH); Alcohol dehydrogenase; (ALDH); Aldehyde dehydrogenase; (ALAS1); 5-Aminolevulinic acid synthase-1; (ANXA2); Annexin A2; (APOB); Apolipoprotein B; (APOE); Apo
Allelic and phenotypic spectrum of plasma triglycerides
Keywords: گلوکوکیناز; ABL; abetalipoproteinemia; ANGPTL3; angiopoietin-like 3; ANGPTL4; angiopoietin-like 4; APOA4; apolipoprotein A-IV; APOA5; apolipoprotein A-V; APOB; apolipoprotein B; APOC2; apolipoprotein C-II; APOC3; apolipoprotein C-III; APOE; apolipoprotein E; CAD; cor
Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich GckD217V mutants
Keywords: گلوکوکیناز; Maturity-onset diabetes of the young, Neonatal diabetes; Glucokinase; β-cell dysfunction; ENU; Experimental genetics
Exendin-4 reduces glycemia by increasing liver glucokinase activity: an insulin independent effect
Keywords: گلوکوکیناز; exendin-4; liver; glucokinase; hepatic insulin resistance;
Real-time analysis of intracellular glucose and calcium in pancreatic beta cells by fluorescence microscopy
Keywords: گلوکوکیناز; GK; glucokinase; ECFP; enhanced cyan fluorescent protein; FRET; fluorescence resonance energy transfer; HK; hexokinase; GLUT; glucose transporter; MH; mannoheptulose; 3-OMG; 3-O-methylglucose; FLIPglu; FLII12Pglu-700μ-δ6; [Ca2+]i; intracellular calcium;
GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation
Keywords: گلوکوکیناز; Ab; antibody; GK; glucokinase; GKRP; glucokinase regulatory protein; Glc; α-d-glucose; HEK293; human embryonic kidney 293 cells; hGK; human glucokinase; MIN6; mouse insulinoma cell; MODY; maturity-onset diabetes of the young; PDB; protein data bank; PNS;
Fermentative glycolysis with purified Escherichia coli enzymes for in vitro ATP production and evaluating an engineered enzyme
Keywords: گلوکوکیناز; 13BPG; 1,3-bisphosphoglycerate; 2PG; 2-phosphoglycerate; 3PG; 3-phosphoglycerate; Adh; alcohol dehydrogenase; CFPS; cell-free protein synthesis; DHAP; dihydroxyacetone phosphate; DTT; dithiothreitol; Eno; enolase; F6P; fructose 6-phosphate; Fba; fructose-
Loss of toll-like receptor 3 function improves glucose tolerance and reduces liver steatosis in obese mice
Keywords: گلوکوکیناز; EMT; epithelial-mesenchymal transition; FDR; false discovery rate; FFA; free fatty acids; G6P; glucose-6-phosphotase; GcK; glucokinase; GO; gene ontology; GTT; glucose tolerance test; HDL-C; high-density lipoprotein cholesterol; HFD; high fat diet; HOMA
Comparative analysis of diatom genomes reveals substantial differences in the organization of carbon partitioning pathways
Keywords: گلوکوکیناز; ACCase; acetyl-CoA carboxylase; ATP-PFK; ATP-dependent phosphofructokinase; CCM; carbon concentrating mechanism; DNRA; dissimilatory nitrate reduction to ammonia; ED; Entner-Dourdoff glycolysis; EGT; endosymbiotic gene transfer; EMP; Embden-Meyerhofâ
Thermal stabilty of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and urea
Keywords: گلوکوکیناز; Diabetes; Glucokinase; Tryptophan fluorescence; Protein stability; Denaturation; Calorimetry
The Zinc Finger Protein ZBTB20 Regulates Transcription of Fructose-1,6-Bisphosphatase 1 and β Cell Function in Mice
Keywords: گلوکوکیناز; Pancreas; Mouse Model; RIP-Cre; Repressor; ChIP; chromatin immunoprecipitation; FBPase; fructose-1,6-bisphosphatase; G-6-P; glucose-6-phosphate; Gk; glucokinase; GSIS; glucose-stimulated insulin secretion; PFK; phosphofructokinase; RT-PCR; reverse-transcr
Hiperglucemia en ayunas y polimorfismo en el promotor de la glucoquinasa (rs1799884)
Keywords: گلوکوکیناز; Hiperglucemia; Glucoquinasa; PolimorfismoHyperglycemia; Glucokinase; Polymorphism
Short communicationGlucokinase inhibitor glucosamine stimulates feeding and activates hypothalamic neuropeptide Y and orexin neurons
Keywords: گلوکوکیناز; Glucosamine; Glucokinase; Food intake; Hypoglycemia; Neuropeptide Y; Orexin; Melanocyte-stimulating hormone; Melanin concentrating hormone; Hypothalamus;
Discovery and hit-to-lead optimization of novel allosteric glucokinase activators
Keywords: گلوکوکیناز; Glucokinase; Allosteric activators; Hit-to-lead optimization; Molecular modeling; Type 2 diabetes;
Cellular glucose availability and glucagon-like peptide-1
Keywords: گلوکوکیناز; Glucagon-like peptide-1; Type 2 diabetes; Glucose uptake; Pancreatic β-cell; Glucokinase; Insulin secretion
ATF3 inhibits PDX-1-stimulated transactivation
Keywords: گلوکوکیناز; ATF3; activating transcription factor 3; ChIP; chromatin immunoprecipitation; ER; endoplasmic recticulum; GCK; glucokinase; PBE; PDX-1 binding element; PDX-1; pancreatic and duodenal homeobox factor-1; UPR; unfolded protein response; Type 2 diabetes; ER s
Chronic glucokinase activation reduces glycaemia and improves glucose tolerance in high-fat diet fed mice
Keywords: گلوکوکیناز; Islet; Insulin secretion; Glucokinase; Glucose tolerance; Insulin resistance; High-fat diet
Rare forms of congenital hyperinsulinism
Keywords: گلوکوکیناز; Congenital hyperinsulinism; Glutamate dehydrogenase; Glucokinase; Exercise-induced hyperinsulinism; HNF4A
Ghrelin neutralization during fasting-refeeding cycle impairs the recuperation of body weight and alters hepatic energy metabolism
Keywords: گلوکوکیناز; 6PGDH; 6-phosphogluconate dehydrogenase; ACCα; acetyl-CoA carboxylase alpha; ACL; ATP citrate lyase; AKT; total serine/threonine kinase protein kinase B; AMPKα; 5â²AMP-activated protein kinase alpha; CPT1A; liver isoform of carnitine palmitoyltransfera
Glucagon-like peptide-1 protects NSC-34 motor neurons against glucosamine through Epac-mediated glucose uptake enhancement
Keywords: گلوکوکیناز; GLP-1; Motor neuron; Glucosamine; Glucose uptake; Glucokinase; Epac
ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells
Keywords: گلوکوکیناز; ARNT; aryl hydrocarbon receptor nuclear translocator; ChREBP; carbohydrate responsive element-binding protein; ChIP; chromatin immunoprecipitation; ChoRE; carbohydrate-responsive element; FAS; fatty acid synthase; GcK; glucokinase; GFP; green fluorescent
Gestational 30% and 40% fat diets increase brain GLUT2 and neuropeptide Y immunoreactivity in neonatal Wistar rats
Keywords: گلوکوکیناز; Glucokinase; Glucose sensing; Leptin; Obesity; Type 2 diabetes20F, 20% fat diet; 30F, 30% fat diet; 40F, 40% fat diet; ARC, arcuate nucleus of the hypothalamus; GK, glucokinase; GLUT2, glucose transporter; NPY, neuropeptide Y
Regulatory role for phosphatidylcholine transfer protein/StarD2 in the metabolic response to peroxisome proliferator activated receptor alpha (PPARα)
Keywords: گلوکوکیناز; ABC; ATP-binding cassette; ACC; Acetyl-Coenzyme A carboxylase; BADGE; Bayesian Analysis of Differential Gene Expression; CPT; Carnitine palmitoyltransferase; CT; CTP:phosphocholine cytidylyltransferase; DHA; docosahexaenoic acid; FAS; fatty acid synthase;
Biotin increases glucokinase expression via soluble guanylate cyclase/protein kinase G, adenosine triphosphate production and autocrine action of insulin in pancreatic rat islets
Keywords: گلوکوکیناز; Biotin; cGMP; Glucokinase; Gene expression; Insulin signaling
Aproximaciones de terapia génica para la diabetes tipo 1
Keywords: گلوکوکیناز; vectores virales; vectores no virales; insulina; glucocinasa; músculo esquelético; hÃgado; regeneración del páncreas; viral vectors; non-viral vectors; insulin; glucokinase; skeletal muscle; liver; pancreas regeneration;
Glucokinase activation induces potent hypoglycemia without recruiting insulin and inhibits food intake in chicken
Keywords: گلوکوکیناز; Glucokinase; Liver; Plasma glucose level; Chicken
AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets
Keywords: گلوکوکیناز; Succinobucol; Probucol; Cytokines; Inflammation; Antioxidant; Oxidative stress; Anti-inflammatory; KATP-channel; Glucose sensitivity; Glucokinase; Calcium; Biphasic; Insulin; Beta-cell; Beta cells; ER stress
A retrospective review of the roles of multifunctional glucose-6-phosphatase in blood glucose homeostasis: Genesis of the tuning/retuning hypothesis
Keywords: گلوکوکیناز; Phosphoenolpyruvate carboxykinase; Carbamyl phosphate; Glucokinase; Glucose-6-phosphatase; Blood glucose regulation
Molecular modeling of BAD complex resided in a mitochondrion integrating glycolysis and apoptosis
Keywords: گلوکوکیناز; Bcl-2 antagonist of cell death; Glucokinase; Kinase; Phosphatase; Molecular simulation
Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators
Keywords: گلوکوکیناز; Glucokinase; Glucokinase activator; Diabetes
Identification of eight new mutations in the GCK gene by DHPLC screening in a Spanish population
Keywords: گلوکوکیناز; Glucokinase; MODY 2; dHPLC; Glucokinase regulatory protein; Genetics
Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators
Keywords: گلوکوکیناز; GK; Glucokinase; Diabetes
Effects of water extract and crude polysaccharides from Liriope spicata var. prolifera on InsR/IRS-1/PI3K pathway and glucose metabolism in mice
Keywords: گلوکوکیناز; Liriope spicata var. prolifera; Type 2 diabetic mice; InsR/IRS-1/PI3K pathway; Glycogen content; Glucokinase; Glucose-6-phosphatase;
Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle
Keywords: گلوکوکیناز; Glucokinase; Diabetes; Enzyme activation; Pyridone; Reactive metabolite
The hexokinase gene family in the zebrafish: Structure, expression, functional and phylogenetic analysis
Keywords: گلوکوکیناز; Danio rerio; Fasted; Fed; Glucokinase; Glucose utilization; Hexokinase; Molecular evolution; Starvation
Hepatic glucokinase activity is the primary defect in alloxan-induced diabetes of mice
Keywords: گلوکوکیناز; Alloxan; Alloxan-induced diabetes; Diabetes mellitus; Glucokinase
Discovery and structure–activity relationships of a novel class of quinazoline glucokinase activators
Keywords: گلوکوکیناز; Glucokinase; Glucokinase activator; Glucose lowering efficacy; Log D; Aqueous solubility; 4,6-Disubstituted quinazoline
Structure–activity relationships of 3,5-disubstituted benzamides as glucokinase activators with potent in vivo efficacy
Keywords: گلوکوکیناز; Glucokinase; Glucokinase activator; 3,5-Disubstituted benzamides; Glucose lowering efficacy; Log D
Discovery of potent and orally active 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as novel allosteric glucokinase activators
Keywords: گلوکوکیناز; Glucokinase; Glucokinase activators; 3-Alkoxy-5-phenoxy-N-thiazolyl benzamides; Glucose-lowering effect
Rearing temperature enhances hepatic glucokinase but not glucose-6-phosphatase activities in European sea bass (Dicentrarchus labrax) and gilthead sea bream (Sparus aurata) juveniles fed with the same level of glucose
Keywords: گلوکوکیناز; European sea bass; Gilthead sea bream; Glucokinase; Glucose; Glucose-6-phosphatase; Temperature
Induction of glucokinase in chicken liver by dietary carbohydrates
Keywords: گلوکوکیناز; Carbohydrate metabolism; Glucokinase; Chicken; Liver
Cyanobacterial glucokinase complements the glucose sensing role of Arabidopsis thaliana hexokinase 1
Keywords: گلوکوکیناز; Arabidopsis; Glucokinase; Glucose sensing; Synechocystis
Hepatic glucokinase and glucose-6-phosphatase responses to dietary glucose and starch in gilthead sea bream (Sparus aurata) juveniles reared at two temperatures
Keywords: گلوکوکیناز; Carbohydrates; Gene expression; Gilthead sea bream; Glucokinase; Glucose-6-phosphatase; Temperature
Insuline et fonction pancréatique
Keywords: گلوکوکیناز; Glucokinase; Kir6.2; Incrétines; Hétérogénéité des cellules β; Voie amplificatrice;
Role of Sp1 and SREBP-1a in the insulin-mediated regulation of glucokinase transcription in the liver of gilthead sea bream (Sparus aurata)
Keywords: گلوکوکیناز; Glucokinase; Insulin; Sp1; Sparus aurata; SREBP-1a; Transcriptional regulation