Kiteplatin: Differential binding between GSH and GMP
Keywords: Kiteplatin; Glutathione; GMP; Platinum-based anticancer drugs; Cisplatin-resistance; cis-1,4-DACH;
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Induction of systemic and mucosal immunity and maintenance of its memory against influenza A virus by nasal vaccination using a new mucosal adjuvant SF-10 derived from pulmonary surfactant in young cynomolgus monkeys
Keywords: APC; antigen presenting cell; CVP; carboxyvinyl polymer; DPPC; 1,2-dipalmitoyl-phosphatidylcholine; ELISA; enzyme-linked immunosorbent assay; GMP; good manufacturing practices; HI; hemagglutination inhibition; IAV; influenza A virus; OD; optical density;
La maladie associée aux immunoglobulines G4
Keywords: IgG4; maladie associée aux IgG4; fibrose; pancréatite auto-immune; plasmablaste; IgG4; Immunoglobulin G4-related disease; fibrosis; autoimmune pancreatitis; plasmablast; ENA; extractible nuclear antigen; FRP; fibrose retro-péritonéale; GMP; glomérulo
The EB66® cell line as a valuable cell substrate for MVA-based vaccines production
Keywords: CEF; chicken embryo fibroblast; CEV; cell-associated enveloped virus; DMEM; Dulbecco's Modified Eagle's Medium; DNA; deoxyribonucleic acid; ELISA; enzyme-linked immunosorbent assay; EMEM; Eagle's minimum essential medium; FBS; Foetal Bovine Serum; G
Normal hematopoiesis and lack of β-catenin activation in osteoblasts of patients and mice harboring Lrp5 gain-of-function mutations
Keywords: GOF; Gain-of-function; AML; Acute myeloid leukemia; LSK; HSC-enriched Linâ Sca-1+Â c-Kit+ cells; LT-HSC; Long-term hematopoietic stem cell; ST-HSC; Short-term hematopoietic stem cell; MPP; Multipotent progenitor; CMP; Common myeloid progenitor; GMP; Gra
Polymerization of wheat gluten and the changes of glutenin macropolymer (GMP) during the production of Chinese steamed bread
Keywords: Polymerization; Gluten; Chinese steamed bread; Protein extractability; Microstructure; GMP; Acetonitrile (PubChem CID: 6342); Trifluoroacetic acid (PubChem CID: 6422); Dithiothreitol (PubChem CID: 446094); Sodium dodecyl sulfate (PubChem CID: 3423265); Ur
Automated manufacturing of chimeric antigen receptor T cells for adoptive immunotherapy using CliniMACS Prodigy
Keywords: automation; CAR19; chimeric antigen receptors; CliniMACS prodigy; GMP; immunotherapy; T-cell transduction; T cells;
Safety evaluation of nuclease P1 from Penicillium citrinum
Keywords: Penicillium citrinum; Nuclease P1; Subchronic toxicity; Genotoxicity; Food; Safety; 2-AA; 2-aminoanthracene; 9-AA; 9-aminoacridine hydrochloride; A/G; albumin:globulin; AF-2; 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide; AMP; adenosine-5â²-monophosphate; bw
Positioning food safety in Halal assurance
Keywords: Certification; GHP; GMP; Halal standard; Halalan and Toyyiban; HACCP; Haram; Islam; Sharia
Parameters and pitfalls to consider in the conduct of food additive research, Carrageenan as a case study
Keywords: Carrageenan; Food additive; Test methods; Vehicles; NCM460 cells; CaCo-2; adenoCArcinoma of COlon cell line; CGN; carrageenan; cps; centipose; Da; Daltons; kDa; kiloDaltons; DMEM; Dulbecco's modified Eagle's medium; FAO; Food and Agriculture Organization
Establishment of correlation between in-silico and in-vitro test analysis against Leishmania HGPRT to inhibitors
Keywords: HGPRT; hypoxanthine-guanine phosphoribosyltransferase; HPRT; hypoxanthine phosphoribosyltransferase; APRT; adenosine phosphoribosyltransferase; XPRT; xanthine phosphoribosyltransferase; CL; cutaneous leishmaniasis; MCL; muco-cutaneous leishmaniasis; VL; v
Time controlled pulsatile transdermal delivery of nicotine: A phase I feasibility trial in male smokers
Keywords: NRT; nicotine replacement therapy; CNS; central nervous system; HPLC-MS; high performance liquid chromatography - mass spectrometry; CRC; clinical research center; GMP; good manufacturing practice; AUC; area under the curve; Transdermal drug delivery; Con
Gene-Corrected Fibroblast Therapy for Recessive Dystrophic Epidermolysis Bullosa using a Self-Inactivating COL7A1 Retroviral Vector
Keywords: AF; anchoring fibril; C7; type VII collagen; DEJ; dermal-epidermal junction; GFP; green fluorescent protein; GMP; Good Manufacturing Practices grade; NHF; normal human fibroblasts; RDEB; recessive dystrophic epidermolysis bullosa; RDEBF; patient-derived r
Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice
Keywords: A1; adenosine receptor type 1; A2A; adenosine receptor type 2A; A3; adenosine receptor type 3; ADP; adenosine diphosphate; AMP; adenosine monophosphate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AOPCP; É,β-methyleneadenosine 5â²-diph
Metabotropic glutamate receptors are involved in the detection of IMP and l-amino acids by mouse taste sensory cells
Keywords: AIDA; (RS)-1-aminoindan-1,5-dicarboxylic acid; Arg; l-arginine; CNQX; cyano-7-nitroquinoxaline-2,3-dione; CPPG; (RS)-α-cyclopropyl-4-phosphonophenylglycine; CTA; conditioned taste aversion; d-AP5; d-(â)-2-amino-5-phosphonopentanoic acid; DHPG; (S)-3,5-
Automated radiosynthesis of GMP quality [18F]HX4 for PET imaging of hypoxia
Keywords: HX4; Fluorine-18; Hypoxia; GMP; Radiosynthesis; Radiostabiliser
Case ReportImmunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient
Keywords: HCC; hepatocellular carcinoma; TCR; T cell receptor; CHB; chronic hepatitis B; GMP; good manufacturing practice; AFP; alpha-fetoprotein; T cell therapy; HBV-specific CD8 T cells; Liver cancer;
The adsorption of allergoids and 3-O-desacyl-4â²-monophosphoryl lipid A (MPL®) to microcrystalline tyrosine (MCT) in formulations for use in allergy immunotherapy
Keywords: MPL®; monophosphoryl lipid A; MCT; microcrystalline tyrosine; WHO; World Health Organisation; EMA; European Medicines Agency; MATA; modified allergen tyrosine adsorbed; C-Hâ¯Ï; carbon hydrogen delocalised aromatic electron interaction; IgE; immunoglo
Regulation of ascorbic acid biosynthesis and recycling during root development in carrot (Daucus carota L.)
Keywords: Ascorbic acid; Root development; Expression profiles; Regulation mechanism; Daucus carota L; APX; ascorbate peroxidase; AsA; reduced ascorbic acid (l-AsA); AO; ascorbate oxidase; BT; 4,7-diphenyl-1,10-phenanthroline; DHA; dehydroascorbate; DHAR; dehydroas
Transcriptional control of vitamin C defective 2 and tocopherol cyclase genes by light and plastid-derived signals: The partial involvement of GENOMES UNCOUPLED 1
Keywords: AsA; l-ascorbic acid; DCMU; 3-(3,4-dichlorophenyl)-1,1-dimethylurea; d-Fru-6P; d-fructose-6-phosphate; d-Glu-6P; d-glucose-6-phosphate; d-Man-1P; d-manose-1-phosphate; d-Man-6P; d-mannose-6-phosphate; DMPBQ; 2,3-dimethyl-5-phytyl-1,4-benzoquinone; GalDH;
Good manufacturing practice (GMP) regulation of herbal medicine in comparative research: China GMP, cGMP, WHO-GMP, PIC/S and EU-GMP
Keywords: Herbal medicine; Good manufacturing practice; GMP; International comparison
Toxicological evaluation of two flavors with modifying properties: 3-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2,2-dimethyl-N-propylpropanamide and (S)-1-(3-(((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)methyl)piperidin-1
Keywords: AUC; area under the curve; CL; plasma clearance; Cmax; peak plasma concentration; EIC; extracted ion chromatogram; FDA; Food and Drug Administration; FEMA; Flavor and Extract Manufacturers Association of the United States; FL-no; FLAVIS number; FMP; flavo
Cryopreservation does not alter main characteristics of Good Manufacturing Process–grade human multipotent mesenchymal stromal cells including immunomodulating potential and lack of malignant transformation
Keywords: cryopreservation; GMP; immunogenicity; immunomodulation; malignant transformation; MSC
ReviewCell therapy for liver disease: From liver transplantation to cell factory
Keywords: ATM; ataxia telangiectasia mutant; APOLT; auxiliary partial orthotopic liver transplantation; ES Cells; embryonic stem cells; FAHâ/â; fumarylacetoacetate-hydrolase-deficient; GMP; Good Manufacturing Practice; HPCs; Hepatic progenitor cells; iHeps; ind
Créer les conditions du succès de la filière industrielle française des thérapies innovantes
Keywords: médicaments de thérapies innovantes; médicaments de thérapies innovantes pour un patient; organisme génétiquement modifié; accès au marché; ADI; aide pour le développement de l'innovation; AEC; autorisation d'essais cliniques; AFM; Associati
Structural and biochemical characterization of GTP cyclohydrolase II from Helicobacter pylori reveals its redox dependent catalytic activity
Keywords: DARP; 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone-5â²-phosphate; DTT; dithiothreitol; GCHI; GTP cyclohydrolase I; hGCHII; GTP cyclohydrolase II from Helicobacter pylori; GCHII; GTP cyclohydrolase II; GCHIII; GTP cyclohydrolase III; GMP; guanosine monop
Absence epileptic activity changing effects of non-adenosine nucleoside inosine, guanosine and uridine in Wistar Albino Glaxo Rijswijk rats
Keywords: A2A receptors; A2A type of Ado receptors; Ado; adenosine; ANOVA; analysis of variance; EEG recording; electroencephalographic recording; GABAA receptors; GABAA type of gamma-aminobutyric acid receptors; GDP; guanosine diphosphate; GMP; guanosine monophosp
Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications
Keywords: ADC; antibody drug conjugate; ALL; acute lymphoid leukemia; AML; acute myeloid leukemia; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EMA; European Medicines Agency; EPR; enhanced permeability and retention effect; FDA; US Food an
L-Plastin S-glutathionylation promotes reduced binding to β-actin and affects neutrophil functions
Keywords: GMP; guanosine monophosphate; IAM; iodoacetamide; NCF; neutrophil cytosolic factor; NOS; nitric oxide synthase; ROS; reactive oxygen species; Chemotaxis; Polarization; Phagocytosis; Bactericidal activity; Nitric oxide; Diabetes; Oxidative stress; Posttran
Hydration, polymerization and rheological properties of frozen gluten-water dough as influenced by thermostable ice structuring protein extract from Chinese privet (Ligustrum vulgare) leaves
Keywords: Thermostable ice structuring proteins; Dehydration of gluten proteins; Depolymerization of glutenin subunits; Rheological properties; TSISPs; thermostable ice structuring proteins extracted from Chinese privet (Ligustrum vulgare) leaves; GMP; glutenin mac
PDE7A1 hydrolyzes cCMP
Keywords: A549; human lung carcinoma cell line; AMP; adenosine 5â²-monophosphate; cAMP; adenosine 3â²,5â²-cyclic monophosphate; B103; rat neuroblastoma cells; CMP; cytidine 5â²-monophosphate; cCMP; cytidine 3â²,5â²-cyclic monophosphate; CyaA; Bordetella pertu
hIL-15 gene-modified human natural killer cells (NKL-IL15) augments the anti-human hepatocellular carcinoma effect in vivo
Keywords: CIK; cytokine-induced killer; DC; dendritic cells; ELISA; enzyme-linked immunosorbent assay; GMP; Good Manufacturing Practice; HCC; hepatocellular carcinoma; IFN-γ; interferon gamma; IL; interleukin; LAK; lymphokine activated killer; MHC; major histocomp
Bench to bedside development of GMP grade Rhenium-188-HEDP, a radiopharmaceutical for targeted treatment of painful bone metastases
Keywords: Rhenium-188; Rhenium-188-HEDP; Radionuclide therapy; Bone metastases; Prostate cancer; GMP;
Synthesis and analysis of potential α1,3-fucosyltransferase inhibitors
Keywords: ADP; adenosine diphosphate; dGDP; deoxyguanosine diphosphate; (h)FucT; (human) fucosyltransferase; IDP; inosine diphosphate; GDP; guanosine diphosphate; GMP; guanosine monophosphate; GT; glycosyltransferase; GTP; guanosine triphosphate; HF9; soluble recom
Production, characterization and foamability of α-lactalbumin/glycomacropeptide supramolecular structures
Keywords: α-la; α-lactalbumin; GMP; glycomacropeptide; HCl; hydrochloric acid; DSC; differential scanning calorimeter; ITC; isothermal titration calorimeter; CD; circular dichroism; VI; volume increase; FS; foam stability; FE; foam expansion; EAI; emulsifying act
Cryopreservation of human monocytes for pharmacopeial monocyte activation test
Keywords: BET; bacterial endotoxins test; BSA; bovine serum albumin; DPBS; Dulbecco's phosphate buffered saline; ECVAM; European Centre for the Validation of Alternative Methods; EDQM; European Directorate for the Quality of Medicines & Health Care; ELISA; enzyme-l
Associate editor: P. HolzerOf worms, mice and man: An overview of experimental and clinical helminth-based therapy for inflammatory bowel disease
Keywords: Helminths; Helminth-derived molecules; Therapy; Inflammatory bowel disease; Colitis; Innate and adaptive immunity; CDAI; Crohn's disease activity index; DC; dendritic cell; DNBS; dinitrobenzene sulfonic acid; DSS; dextran sulfate sodium; GMP; good manufac
Influence of additives to the formulation of n.c.a. [11C]PiB on sterile filter performance
Keywords: Pittsburgh Compound B; PiB; Sterile filtration; Viscosity; GMP; PET;
Transcutaneous immunization of healthy volunteers with an attenuated Listeria monocytogenes vaccine strain and cholera toxin adjuvant
Keywords: CBC; complete blood count; CEF; CMV, EBV, and Influenza virus; CFU; colony forming units; GMP; good manufacturing processes; IFN; interferon; LLO; listeriolysin; LT; E. coli heat labile toxin; PBMC; peripheral blood mononuclear cells; PHA; phytohemaggluti
Evaluation of monosodium glutamate, disodium inosinate and guanylate umami taste by an electronic tongue
Keywords: Sensor; Electronic tongue; Umami; MSG; IMP; GMP;
Transposon leads to contamination of clinical pDNA vaccine
Keywords: Clinical-grade plasmid DNA; GMP; Gene therapy; HPV16; Transposon; DNA vaccination;
Ameliorating effects of casein glycomacropeptide on obesity induced by high-fat diet in male Sprague-Dawley rats
Keywords: FAS; fatty acid synthase; GMP; casein glycomacropeptide; GPDH; glycerol-3-phosphate dehydrogenase; GSH-Px; glutathione peroxidase; HDL-C; high-density lipoprotein cholesterol; HF; high fat; LDL-C; low-density lipoprotein cholesterol; IL; interleukin; MDA;
Transgenic expression of BRCA1 disturbs hematopoietic stem and progenitor cells quiescence and function
Keywords: HSCs; hemaopoietic stem cells; BRCA1; breast cancer type 1 susceptibility protein; FACS; fluorescence activated cell sorter; LT-HSCs; long-term HSCs; ST-HSCs; short-term HSCs; MPPs; multipotent progenitors; CLPs; common lymphoid progenitors; CMPs; common
Safety evaluation and nutritional composition of a Fraxinus excelsior seed extract, FraxiPureâ¢
Keywords: AE; adverse event; ALT; alanine transaminase; AST; aspartate aminotransferase; AUC; area under the curve; CB; cytokinesis-blocked; CRF; case report form; FBS; fetal bovine serum; GCP; Good Clinical Practice; GGTP; gamma-glutamyl transpeptidase; GMP; Good
Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered al
Keywords: CF; colonization factor; CT; cholera toxin B subunit; CTB; cholera toxin binding subunit; dmLT; double-mutant LT; ELISA; enzyme linked immunosorbent assay; ETEC; enterotoxigenic Eschericia coli; EV; ETEC vaccine; GMP; good manufacturing practice; i.g. imm
Guidance on the establishment of acceptable daily exposure limits (ADE) to support Risk-Based Manufacture of Pharmaceutical Products
Keywords: Active pharmaceutical ingredients; Acceptable daily exposure; GmP; Cleaning validation;
The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity
Keywords: 5-FU; 5-fluorouracil; BrdU; 5-bromo-2â²-deoxyuridine; FACS; fluorescence activated cell sorting; FAK; focal adhesion kinase; GMP; granulocyte-monocyte progenitor; HPC; hematopoietic progenitor cell; KLS; c-Kit+lineageâSca-1+; LT-HSC; long-term hemato
ReviewNanocarriers for intravenous injection-The long hard road to the market
Keywords: API; active pharmaceutical ingredient; CARPA; complement activation-related pseudoallergy; DLS; dynamic light scattering; EMA; European Medicines Agency; EPR; enhanced permeation and retention; EU; European Union; FDA; Food and Drug Administration; GMP; G
Fully automated radiosynthesis of both enantiomers of [18F]Flubatine under GMP conditions for human application
Keywords: Fluorine-18; NCFHEB; Flubatine; α4β2 Nicotinic acetylcholine receptors; GMP; Automation
Variation of high-molecular-weight glutenin subunits and glutenin macropolymer particle distribution in wheat grains produced under different water regimes
Keywords: Triticum aestivum; HMW-GS; GMP; Irrigation; Rainfed cultivation