دانلود مقالات ISI درباره Gpcr + ترجمه فارسی

Lysophosphatidic acid receptor (LPAR) modulators: The current pharmacological toolbox

Keywords: Lysophosphatidic acid; GPCR; Agonist; Antagonist; Small molecule; Idiopathic pulmonary fibrosis; Systemic sclerosis; Cancer;

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2015 سفارش ترجمه

Stereoselective synthesis, biological evaluation, and modeling of novel bile acid-derived G-protein coupled Bile acid receptor 1 (GP-BAR1, TGR5) agonists

Keywords: GPCR; G protein-coupled receptor; BAs; bile acids; CDCA; chenodeoxycholic acid; CA; cholic acid; LCA; lithocholic acid; UDCA; ursodeoxycholic acid; FXR; farnesoid X receptor; NRs; nuclear receptors; LBD; ligand-binding domain; cAMP; cyclic adenosine monop

دانلود رایگان متن کامل مقاله ISI 62 صفحه سال انتشار : 2015 سفارش ترجمه

Benzylpiperidine variations on histamine H3 receptor ligands for improved drug-likeness

Keywords: GPCR; Histamine H3 receptor; Antagonists; Drug-likeness; Lipophilicity

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Replacement of amide with bioisosteres led to a new series of potent adenosine A2A receptor antagonists

Keywords: Bioisostere; Adenosine receptor; Antagonist; GPCR; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Discovery of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists

Keywords: GPR119; GPCR; Agonist; Type 2 diabetes; Oral glucose tolerance test;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity

Keywords: PTH; parathyroid hormone; PTHrP; parathyroid hormone-related peptide; 125I-rPTH(1-34); 125I-[Nle8,21,Tyr34]rPTH(1-34)NH2; MBS; membrane binding solution; GPCR; G protein-coupled receptor; N domain; N-terminal extracellular domain; PTH1; PTH/PTHrP rece

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Detection and distribution of opioid peptide receptors in porcine myocardial tissue

Keywords: APAAP; alkaline phosphatase-anti-alkaline phosphatise; BCIP/NBT; 5-bromo-4-chloro-3-indolylphosphate/nitroblue tetrazolium; EOP; endogenous opioid peptides; ERK; extracellular regulated kinase; GPCR; G-protein-coupled receptors; mKATP-channels; ATP-depend

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Somatostatin 4 receptor activation modulates TPRV1 currents in dorsal root ganglion neurons

Keywords: sst4 Receptor; Somatostatin agonist J-2145; DRG; TRPV1; GPCR; ATP; adenosine triphosphate; CFA; complete Freund's adjuvant; CNS; central nervous system; DMEM; Dulbecco's modified Eagle medium; DRG; dorsal root ganglion neurons; GPCR; G protein coupled rec

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

L-shaped PLS analysis of multiple inhibitory activities of adrenergic alpha receptors using ligand and protein matrices

Keywords: Chemogenomics; PLS; LPLS; SSOM; GPCR;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

PLEKHG2/FLJ00018, a Rho family-specific guanine nucleotide exchange factor, is tyrosine phosphorylated via the EphB2/cSrc signaling pathway

Keywords: DH; dbl homology; DHR; dock homology region; DMEM; Dulbecco's modified Eagle's medium; Eph; ephrin receptor; FBS; fetal bovine serum; GAP; GTPase activating protein; G-protein; guanosine triphosphate-binding protein; GPCR; heterotrimeric G-protein-coupled

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Stereospecific requirement of cholesterol in the function of the serotonin1A receptor

Keywords: 5-HT1A receptor; 5-hydroxytryptamine-1A receptor; 8-OH-DPAT; 8-hydroxy-2(di-N-propylamino)tetralin; BCA; bicinchoninic acid; CHAPS; 3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate; DMPC; dimyristoyl-sn-glycero-3-phosphocholine; DPH; 1,6-dipheny

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

CB2 cannabinoid receptor is a novel target for third-generation selective estrogen receptor modulators bazedoxifene and lasofoxifene

Keywords: SERM; selective estrogen receptor modulator; CB1; cannabinoid receptor 1; CB2; cannabinoid receptor 2; GPCR; G protein-coupled receptor; FDA; food and drug administration; HTRF; homogenous time resolved fluorescence; Cannabinoid receptor; Inverse agonist;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages

Keywords: EBI2; GPR183; GPCR; Oxysterols; CH25H; Macrophages;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

N-methylthioacetylation of RYYRIK-NH2 with enhanced specific binding affinity and high antagonist activity for nociceptin ORL1 receptor

Keywords: DTT; dithiothreitol; Fmoc; 9-fluorenylmethoxycarbonyl; GPCR; G protein-coupled receptor; HBTU; 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; HOBt; 1-hydroxybenzotriazole; MALDI-TOF; matrix-assisted laser desorption ionization t

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Solubilization and reconstitution of the mu-opioid receptor expressed in human neuronal SH-SY5Y and CHO cells

Keywords: Neuropeptide; G protein-coupled receptor; GPCR; Solubilization; Reconstitution; Opioid receptors;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Ca2+ signaling in taste bud cells and spontaneous preference for fat: Unresolved roles of CD36 and GPR120

Keywords: Lipids; Taste receptor cells; CD36; GPR120; Stim1; Ca2+ influx factor; Fatty acids; AA; arachidonic acid; [Ca2+]i; free intracellular calcium concentration; CaM; calmodulin; CIF; calcium influx factor; cPLA2; cytosolic phospholipase A2; GL; glossopharynge

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Discovery of N-methyltetrahydroprotoberberines with κ-opioid receptor agonists-opioid receptor agonist activities from corydalis yanhusuo W. T. Wang by using two-dimensional liquid chromatography

Keywords: GPCR; TCMs; 2D separation; Corydalis yanhusuo W.T. Wang; κ-opioid receptor;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Endothelin-1 but not angiotensin II contributes to functional aging in murine carotid arteries

Keywords: Angiotensin II (PubChem CID: 172198); Endothelin-1 (PubChem CID: 16212950); L-NG-nitroarginine methyl ester (PubChem CID: 39836); SQ 29,548 (PubChem CID: 5271); Age; Atherosclerosis; Artery; Cyclooxygenase; Dementia; GPCR; gp91ds-tat; NADPH; Nox; Oxidativ

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Monitoring intracellular calcium in response to GPCR activation using thin-film silicon photodiodes with integrated fluorescence filters

Keywords: GPCR; Cell; Fluorescence; Calcium; Amorphous silicon; Integrated detection

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Homo- and hetero-oligomerization of β2-adrenergic receptor in receptor trafficking, signaling pathways and receptor pharmacology

Keywords: AR; adrenergic receptor; AT1R; angiotensin II type 1 receptor; Bk2R; bradykinin type 2 receptor; BRET; bioluminescence resonance energy transfer; cAMP; cyclic adenosine monophosphate; CB1R; cannabinoid type 1 receptor; Co-IP; co-immunoprecipitation; CREB;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity

Keywords: 7TM; seven transmembrane spanning; A1R; adenosine A1 receptor; DVL; disheveled; FRAP; fluorescence recovery after photobleaching; FZD; Frizzled; GFP; green fluorescent protein; GPCR; G protein-coupled receptor; NECA; 5′-N-ethylcarboxamidoadenosine; NEM;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Ultrapure ajulemic acid has improved CB2 selectivity with reduced CB1 activity

Keywords: AJA; ajulemic acid; DMHR; 1,1-dimethylheptyl resorcinol; GPCR; G-protein coupled receptor; HRMS; high resolution mass spectrometry; IPA; isopropyl alcohol; JBT; JB Therapeutics Inc.; PGJ; 15-deoxy-Δ12,14-PGJ2; PMD; p-menthadienol; THC; Δ9-tetrahydrocann

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Human α1-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines

Keywords: [3H] prazosin; [7-methoxy-3H] prazosin; [3H]-OH-DPAT; 8-[3H-hydroxy-N,N-di-n-propyl-2-aminotetralin]; BPH; benign prostatic hyperplasia; AR; adrenoceptor; 5-HT1A-R; serotonin receptor 1A; D3-R; dopamine D3-receptor; DMEM; Dulbecco's modified Eagle's m

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

An aspartate in the second extracellular loop of the α1B adrenoceptor regulates agonist binding

Keywords: GPCR; α1B Adrenergic receptor; Receptor activation; Second extracellular loop;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Mechanisms that underlie the internalization and extracellular signal regulated kinase 1/2 activation by PKR2 receptor

Keywords: AT1AR; angiotensin type 1A receptor; ConA; Concanavalin A; DN-GRK; dominant-negative G-protein-coupled receptor kinase 2; EGFP; enhanced green fluorescent protein; ERK; extracellular signal regulated kinase; GPCR; G-protein-coupled receptors; GRK; GPCR ki

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Molecular cloning and functional characterization of the diapause hormone receptor in the corn earworm Helicoverpa zea

Keywords: GPCR; Neuropeptide; Insect; Peptidomimetic;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Using pharmacological chaperones to restore proteostasis

Keywords: NN-DNJ (PubChem CID: 501640); E4031 (PubChem CID: 3185); Nicotine (PubChem CID: 89594); GABA (PubChem CID: 119); SR121463 (PubChem CID: 9810773); Naltrexone (PubChem CID: 5360515); Pharmacological chaperone; Proteostasis; Chaperone; ERAD; Protein misfoldi

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Roles of intraloops-2 and -3 and the proximal C-terminus in signalling pathway selection from the human calcium-sensing receptor

Keywords: GPCR; G-protein coupled receptor; CaSR; calcium-sensing receptor; PI-PLC; phosphatidylinositol-specific phospholipase-C; VFT; Venus FlyTrap; CR; Cysteine-rich; iL; intraloop; cAMP; adenosine 3′,5′-cyclic monophosphate; pERK; phosphorylated extracellul

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Membrane-associated cargo recycling by tubule-based endosomal sorting

Keywords: BAR; Bin/Amphiphysin/Rvs; ERC; endosome recycling compartment; FERM; 4.1/ezrin/radixin/moesin; GPCR; G protein coupled receptor; PDZ; PSD-95/Dlg1/Zo-1; PX; phox homology; SNX; sorting nexin; TEN; tubular endosomal network; TfR; transferrin receptor; TGN;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Tritium-labelled isovaleryl-RYYRIK-NH2 as potential antagonist probe for ORL1 nociceptin receptor

Keywords: Boc; butoxycarbonyl; Bmax; receptor density; DMEM; Dulbecco's Modified Eagle's Medium; DMF; N,N-dimethylformamide; FBS; fetal bovine serum; GPCR; G protein-coupled receptor; HBTU; 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphat

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Pharmacoperones and the calcium sensing receptor: Exogenous and endogenous regulators

Keywords: ADH; autosomal dominant hypocalcemia; CaSR; calcium sensing receptor; xCT; cystine-glutamate transporter; DHPs; dihydropyridines; EAAT; excitatory amino acid transporter; EGFR; endothelial growth factor receptor; ER; endoplasmic reticulum; ERK1/2; extrace

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Neuropeptidergic control of the hindgut in the black-legged tick Ixodes scapularis

Keywords: Neuropeptide; G protein-coupled receptor; GPCR; Hindgut; Excretion;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

ADP-ribosylation factor 6 regulates endothelin-1-induced lipolysis in adipocytes

Keywords: ARF6; ADP-ribosylation factor 6; ET-1; endothelin-1; ETAR; endothelin type A receptor; ETBR; endothelin type B receptor; GPCR; G-protein coupled receptor; IR; insulin resistance; GLUT4; glucose transporter type 4; ERK; extracellular-signal regulated kinas

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Improving the apo-state detergent stability of NTS1 with CHESS for pharmacological and structural studies

Keywords: GPCR; G protein-coupled receptor; IMP; integral membrane protein; CHESS; cellular high-throughput encapsulation solubilization and screening; NT; neurotensin peptide; FACS; fluorescence-activated cell sorting; EDTA; ethylenediaminetetraacetic acid; DDM; n

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Tubulin, actin and heterotrimeric G proteins: Coordination of signaling and structure

Keywords: G protein; GPCR; Cytoskeleton; Tubulin; Actin; Microtubule;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Mutations in arrestin-3 differentially affect binding to neuropeptide Y receptor subtypes

Keywords: GPCR; G protein-coupled receptor; arr; arrestin; NPY; neuropeptide Y; Y1R; neuropeptide Y1 receptor; Y2R; neuropeptide Y2 receptor; BRET; bioluminescence resonance energy transfer; ANOVA; analysis of variance; arr-3-K2A; arrestin-3-Lys11 AlaLys12Ala; arr-

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

C5aR and C5L2 act in concert to balance immunometabolism in adipose tissue

Keywords: ASP; acylation stimulating protein; C5L2; C5aR-like receptor 2; GPCR; G protein-coupled receptor; KC; keratinocyte chemoattractant; MCP-1; monocyte chemoattractant protein -1; TGS; triglyceride synthesis; Inflammation; Adipose tissue; Acylation Stimulatin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

The eIF2B-interacting domain of RGS2 protects against GPCR agonist-induced hypertrophy in neonatal rat cardiomyocytes

Keywords: RGS protein; Cardiac hypertrophy; G protein; GPCR; Protein synthesis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Differential involvement of signaling pathways in the regulation of growth hormone release by somatostatin and growth hormone-releasing hormone in orange-spotted grouper (Epinephelus coioides)

Keywords: GH; growth hormone; SRIF; somatotropin release-inhibitory factor; GHRH; GH-releasing hormone; PACAP; pituitary adenylate cyclase-activating peptide; DA; dopamine; GnRH; gonadotropin-releasing hormone; GPCR; G-protein-coupled receptor; SSTR; somatostatin r

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

CommentaryGHB receptor targets in the CNS: Focus on high-affinity binding sites

Keywords: BnOPh-GHB; 4-hydroxy-4-[4-(2-iodobenzyloxy)phenyl]butanoate; DS; discriminative stimulus; GABA; γ-aminobutyric acid; GABAB; GABA subtype B; GABAA; GABA subtype A; GBL; γ-butyrolactone; GHB; γ-hydroxybutyric acid; GPCR; G protein-coupled receptor; HOCPC

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Molecular characterization and expression profiles of olfactory receptor genes in the parasitic wasp, Microplitis mediator (Hymenoptera: Braconidae)

Keywords: OR; olfactory receptor; GPCR; G-protein coupled receptor; ORco; co-expression olfactory receptor; TM; transmembrane protein; EST; expressed sequence tag; GO; gene ontology; GSP; gene specific primer; Microplitis mediator; Antennal cDNA library; Olfactory

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

FSHR polymorphism p.N680S mediates different responses to FSH in vitro

Keywords: FSH; follicle-stimulating hormone; FSHR; FSH receptor; PKA; protein kinase a; ERK1/2; extracellular signal-regulated kinase; CREB; cAMP-responsive element binding protein; MAPK; mitogen-activated protein kinase; MEK; kinase; StAR; steroidogenic acute regu

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

A tagged parathyroid hormone derivative as a carrier of antibody cargoes transported by the G protein coupled PTH1 receptor

Keywords: Parathyroid hormone; PTH1 receptor; Osteoblast; Receptor-mediated transport; CM; conditioned medium; mCherry; mCherry fluorescent protein; EGFP; enhanced green fluorescent protein; GPCR; G protein coupled receptor; HRP; horseradish peroxidase; PTH; parath

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Pharmacological chaperoning: A primer on mechanism and pharmacology

Keywords: Pharmacological chaperone; Pharmacoperone; Chaperoning; Misfolding mutant; Rescue; GPCR; Endoplasmic reticulum; Calnexin; Protein folding disorders;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Diagnostic and therapeutic aspects of β1-adrenergic receptor autoantibodies in human heart disease

Keywords: β1AR; β1 adrenergic receptor; CHF; chronic heart failure; DCM; dilated cardiomyopathy; ELISA; enzyme linked immune assay; FRET; fluorescence resonance energy transfer; GPCR; G-protein coupled receptor; IA; immune apheresis, extracorporeal absorption of

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Simultaneous Adrenal and Cardiac G-Protein-Coupled Receptor-Gβγ Inhibition Halts Heart Failure Progression

Keywords: catecholamines; fibrosis; heart failure; hypertrophy; sympathetic nervous system; AR; adrenergic receptors; βARKct; a truncated Gβγ-binding GRK2 peptide that lacks the kinase domain; CA; catecholamines; GPCR; G-protein-coupled receptor; GRK2; G-prote

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Unifying Family A GPCR Theories of Activation

Keywords: GPCR; Activation; Constitutive activity; Conservational analysis5HT2A, serotonin 2A receptor; A2A, adenosine A2A receptor; CA, constitutive activity; CAM, constitutively active mutant; FSHR, follicle stimulating hormone receptor; GPCR, G protein-coupled r

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by ETAR-dependent JNK/AP-1 pathway

Keywords: ET-1; endothelin-1; CTGF; connective tissue growth factor; DN; dominant-negative mutant; α-SMA; α-smooth muscle actin; ECM; extracellular matrix; BAL; bronchoalveolar lavage; GPCR; G protein-coupled receptor; JNK; c-Jun N-terminal kinase; AP-1; activato

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Probing biased/partial agonism at the G protein-coupled A2B adenosine receptor

Keywords: GPCR; Adenosine receptor; Purines; Cyclic AMP; Calcium; Arrestin; BAY60-6583 (BAY, LUF6210); 2-[[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]acetamide; cyclic AMP (cAMP); 3′5′-cyclic adenosine monophosphate; CGS21680; 2-[p-(2

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Prostaglandin D2 induces apoptosis of human osteoclasts through ERK1/2 and Akt signaling pathways

Keywords: CRTH2; chemoattractant receptor homologous molecule expressed on T-helper type 2 cells; DMSO; dimethyl sulfoxide; DP; d-Type prostanoid; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; GPCR; G protein-coupled receptor; GRK5; GPCR kina

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه