دانلود مقالات ISI درباره Gpcr + ترجمه فارسی

Anti-platelet activity of a three-finger toxin (3FTx) from Indian monocled cobra (Naja kaouthia) venom

Keywords: ADP; adenosine di-phosphate; FITC; fluorescein isothiocyanate; GPCR; G-protein coupled receptor; MW; molecular weight; RP-HPLC; reversed phase high performance liquid chromatography; SPR; surface plasma resonance; Indian cobra venom; KT-6.9; Anti-platelet

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

The discovery of the benzazepine class of histamine H3 receptor antagonists

Keywords: H3 receptor antagonist; GPCR; Benzazepine; Alzheimer's disease; Neurotransmitters; Histamine;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs

Keywords: GPCR; MCHR1 antagonist; Fragment; Bioisostere; Conformation;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

CB1 and CB2 receptors are novel molecular targets for Tamoxifen and 4OH-Tamoxifen

Keywords: 4OH-Tam; 4OH-Tamoxifen; AC; adenylyl cyclase; CB1R; cannabinoid receptor type 1; CB2R; cannabinoid receptor type 2; CHO; Chinese hamster ovary; CP-55,940; 5-(1,1-dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]phenol; DMEM; Dulbecco's modific

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Detecting ligand interactions with G protein-coupled receptors in real-time on living cells

Keywords: GPCR; G protein-coupled receptor; pPYY; porcine peptide YY; hY2R; human Y2 receptor; GRPR; gastrin-releasing peptide receptor; 125I; iodine-125; 111In; indium-111; GPCR; Real-time; LigandTracer; Interaction Map; Kinetics; Heterogeneity;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Activation of lysophosphatidic acid receptor by gintonin inhibits Kv1.2 channel activity: Involvement of tyrosine kinase and receptor protein tyrosine phosphatase α

Keywords: GT; gintonin; LPA receptor; lysophosphatidic acid receptor; GPCR; G-protein coupled receptor; RPTP alpha; tyrosine phosphatase alpha; Ginseng; Gintonin; LPA receptor; Potassium channel; Tyrosine kinase; Receptor protein tyrosine phosphatase α;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Identification of a novel benzimidazole derivative as a highly potent NPY Y5 receptor antagonist with an anti-obesity profile

Keywords: Obesity; NPY Y5 receptor antagonist; GPCR; Benzimidazole; Gauche effect;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

N-Acyl-N′-arylpiperazines as negative allosteric modulators of mGlu1: Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats

Keywords: Glutamate; GPCR; mGlu1; Allosteric modulator; CNS; Piperazine;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Ubiquitination of the heterotrimeric G protein α subunits Gαi2 and Gαq is prevented by the guanine nucleotide exchange factor Ric-8A

Keywords: GPCR; G-protein-coupled receptor; GEF; guanine nucleotide exchange; CHX; cycloheximide; Ric-8A; Gαq; Gαi; Ubiquitination;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Acidosis blocks CCAAT/enhancer-binding protein homologous protein (CHOP)- and c-Jun-mediated induction of p53-upregulated mediator of apoptosis (PUMA) during amino acid starvation

Keywords: AAR; amino acid response; Apaf-1; apoptotic protease-activating factor-1; ATF; activating transcription factor; Bcl-2; B cell lymphoma-2; Bax; Bcl-2-associated X protein; Bim; Bcl-2-interacting mediator of cell death; CHOP; CCAAT/enhancer-binding protein

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Biochemical analysis of a rhodopsin photoactivatable GFP fusion as a model of G-protein coupled receptor transport

Keywords: GPCR; G-protein coupled receptor; ROS; rod outer segment; C-terminus; carboxy-terminus; MDCK; Madin-Darby Canine Kidney; IMCD; inner medullary collecting duct; paGFP; photoactivatable GFP; XOP; Xenopus opsin promoter; i3 loop; intracellular loop 3; OCT;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Opportunities for functional selectivity in GPCR antibodies

Keywords: GPCR; Ligand induced conformation; Biased signaling; Monoclonal antibody; Therapeutic antibody;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

A genome-wide survey of photoreceptor and circadian genes in the coral, Acropora digitifera

Keywords: PRCs; photoreceptor cells; GPCR; G protein-coupled receptor; Cry; cryptochrome; ESTs; expressed sequence tags; Coral genome; Circadian regulatory network genes; Photoreceptors; Tandem duplication; Anthozoan;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

CC chemokine receptor-3 as new target for age-related macular degeneration

Keywords: AMD; age-related macular degeneration; CCR3; CC chemokine receptor-3; CEC; choroidal endothelial cell; CNV; choroidal neovascularization; FFA; fluorescein fundus angiography; GPCR; G-protein-coupled receptor; MCP1; monocyte chemoattractant protein-1; OCT;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Mechanism of dopamine D2 receptor-induced Ca2 + release in PC-12 cells

Keywords: DR; dopamine receptor; PLC; phospholipase C; CaMKII; calmodulin kinase II; IP3; inositol 1,4,5-trisphosphate; IP3R; inositol 1,4,5-trisphospate receptor; PKA; protein kinase A; GPCR; G protein coupled receptor; DMSO; dimethylsulfoxid; EC50; 50% effective

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Adenosine A1 receptors heterodimerize with β1- and β2-adrenergic receptors creating novel receptor complexes with altered G protein coupling and signaling

Keywords: GPCR; G protein-coupled receptors; A1AR; A1 adenosine receptor; β1R & β2R; β-adrenergic receptor subtypes; HEK-293; human embryonic kidney cells; IP; immunoprecipitation; IB; immunoblotting; IF; immunofluorescence; cAMP; cyclic adenosine monophosphate;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists

Keywords: H3 receptor; Histamine; GPCR; Clinical candidate; Receptor antagonists; Neurotransmitters; Lead optimisation;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Differential regulation of chemotaxis: Role of Gβγ in chemokine receptor-induced cell migration

Keywords: CHO; Chinese hamster ovary; CCL3; Chemokine ligand 3; CCR5; Chemokine receptor 5; DMEM; Dulbecco's modified Eagle's medium; EDTA; Ethylenediaminetetraacetic acid; ERK; Extracellular signal-regulated kinases; FCS; Foetal calf serum; GPCR; G protein coupled

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Real-time detection of the chemokine CXCL12 in urine samples by surface plasmon resonance

Keywords: GPCR; G protein-coupled receptor; VSVG; vesicular stomatitis virus gene; RA; rheumatoid arthritis; GAG; glycosaminoglycan; CXCR4; lentiviral particle; rheumatoid arthritis; GPCR;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Cholesterol induces cardiac hypertrophy by activating the AKT pathway

Keywords: IGF; insulin growth factor; MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; PI3K; phosphatidylinositol-3-kinase; GPCR; G-protein-coupled receptor; mTOR; mammalian target of rapamycin; GSK3β; phospho-glycogen synthase k

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Short CommunicationTwo newly identified exons in human GRM1 express a novel splice variant of metabotropic glutamate 1 receptor

Keywords: mGlu; metabotropic glutamate; RACE; rapid amplification of cDNA ends; UTR; untranslated region; GPCR; G protein-coupled receptor; PLC; phospholipase C; PCR; polymerase chain reaction; RT; reverse transcription; GRM1; Metabotropic glutamate 1 receptor; mGl

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Species sequence differences determine the interaction of GnRH receptor with the cellular quality control system

Keywords: GPCR; ER protein retention; GnRH receptor; Calnexin; Protein trafficking;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Conjugated linoleic acid-induced apoptosis in mouse mammary tumor cells is mediated by both G protein coupled receptor-dependent activation of the AMP-activated protein kinase pathway and by oxidative stress

Keywords: AMPK; AMP-activated protein kinase; 2-APB or APB; 2-aminoethyl diphenylborinate; BAPTA-AM; 1,2-bis(o-aminophenoxy)-ethane-N,N,-N',N'-tetraacetic acid tetraacetoxy-methyl ester; CaMKKα; calcium/calmodulin-dependent protein kinase kinase α; CLA; conjugate

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787

Keywords: Histamine H4 receptor; GPCR; Pyrido[3,2-d]pyrimidine; hERG; Residence time; PF-3893787;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Study on human GPCR-inhibitor interactions by proteochemometric modeling

Keywords: GPCR; G protein-coupled receptor; PCM; proteochemometric; TM; transmembrane; 5HT1A; 5-hydroxytrptamine receptor 1A; 5HT1B; 5-hydroxytrptamine receptor 1B; 5HT2A; 5-hydroxytrptamine receptor 2A; ACM1; muscarinic acetylcholine receptor M1; ADA1D; adrenocept

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Expression and function of OXE receptor, an eicosanoid receptor, in steroidogenic cells

Keywords: OXE-R; oxoeicosanoid receptor; OXER1; oxoeicosanoid receptor gene; AA; arachidonic acid; StAR; steroidogenic acute regulatory protein; 5-LOX; 5-lipoxygenase; 5-HETE; 5-hydroxyeicosatetraenoic acid; 5-HpETE; 5-hydroperoxyeicosatetraenoic acid; 5-oxo-ETE; 5

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Identification and expression of PBAN/diapause hormone and GPCRs from Aedes aegypti

Keywords: PBAN; Diapause hormone; Neuropeptide; Receptor; GPCR; Aedes aegypti;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

New α-adrenergic property for synthetic MTβ and CM-3 three-finger fold toxins from black mamba

Keywords: Muscarinic toxin; Muscarinic receptor; Adrenergic toxin; Adrenoceptor; Three-finger fold toxin; GPCRs; GPCR; G-protein coupled receptor; mAChRs; muscarinic acetylcholine receptors; MTs; muscarinic toxins; NMS; N-methylscopolamine; HCTU; 2-(6-Chloro-1H-ben

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Lysophosphatidylethanolamine utilizes LPA1 and CD97 in MDA-MB-231 breast cancer cells

Keywords: LPE; lysophosphatidylethanolamine; LPA; lysophosphatidic acid; LPG; lysophosphatidylglycerol; LPS; lysophosphatidylserine; VPC32183; (S)-Phosphoric acid mono-{2-octadec-9-enoylamino-3-[4-(pyridin-2-ylmethoxy)-phenyl]-propyl} ester; Ki16425; 3-(4-[4-([1-(2

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Activation of cAMP-response element-binding protein is positively regulated by PKA and calcium-sensitive calcineurin and negatively by PKC in insect

Keywords: Insect; GPCR; AKHR; CREB; PKC; Calcium; Calcineurin;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Identification of a Rho family specific guanine nucleotide exchange factor, FLJ00018, as a novel actin-binding protein

Keywords: G protein; guanosine triphosphate binding protein; Rho; Rho family small GTPase; GEF; guanine-nucleotide exchange factor; RhoGEF; Rho specific GEF; GPCR; heterotrimeric G protein coupled receptor; PBS; phosphate-buffered saline; FLJ00018; Actin; G protein

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Interaction of PACAP with Sonic hedgehog reveals complex regulation of the Hedgehog pathway by PKA

Keywords: 7-TM; seven transmembrane domain; AC; adenylate cyclase; AKAP; A-kinase anchoring protein; Bnz-cAMP; N6-benzoyl-cAMP; 8-CPT; 8-CPT-2-Me-cAMPS; cGCPs; cerebellar granule cell progenitors; IBMX; isobutylmethylxanthine; FSK; forskolin; GliA; Gli activator; G

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Rit subfamily small GTPases: Regulators in neuronal differentiation and survival

Keywords: CA; constitutively active; cAMP; cyclic adenosine monophosphate; CaM; calmodulin; CCI; controlled cortical impact; CREB; cAMP response element binding protein; CRIB; Cdc42/Rac interactive binding; DA; dopamine; DAT; dopamine transporter; DN; dominant nega

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

C5L2 and C5aR interaction in adipocytes and macrophages: Insights into adipoimmunology

Keywords: ASP; acylation-stimulating protein; BRET; bioluminescence resonance energy transfer; C5L2; C5aR-like receptor 2; GPCR; G protein-coupled receptor; TGS; triglyceride synthesis; Inflammation; Adipose tissue; Receptor dimerization;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

G protein-coupled receptor kinase 2 (GRK2) is a Rho-activated scaffold protein for the ERK MAP kinase cascade

Keywords: CNK1; connector enhancer of KSR-1; DGKθ; diacylglycerol kinase θ; EGF; epidermal growth factor; GIT; GRK-interacting protein; GPCR; G protein-coupled receptor; GRK; GPCR kinase; KSR-1; kinase suppressor of ras-1; MAPK; mitogen-activated protein kinase;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1

Keywords: Glutamate; GPCR; mGlu1; Allosteric modulator; CNS; Octahydropyrrolo[3,4-c]pyrrole;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Backbone cyclic helix mimetic of chemokine (C-C motif) receptor 2: A rational approach for inhibiting dimerization of G protein-coupled receptors

Keywords: ACN; acetonitrile allocallyloxycarbonyl; BBB; blood brain barrier; Boc; t-butyloxycarbonyl; BTC; bis(trichloromethyl)carbonate; CCR2; chemokine (C-C motif) receptor 2; CCR5; chemokine (C-C motif) receptor 5; CNS; central nervous system; DIPEA; diisopr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Binding mode characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives via docking in opioid receptor crystal structures and site-directed mutagenesis studies: Application of the 'message-address' concept in development of mu op

Keywords: Mu opioid receptor; Selective antagonists; Crystal structures; Automated docking; Site-directed mutagenesis; GPCR;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Selective Knockout of the Casein Kinase 2 in D1 Medium Spiny Neurons Controls Dopaminergic Function

Keywords: CK2; dopamine; dopamine receptor; GPCR; hyperactivity; medium spiny neurons;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Binding of Gq protein stabilizes the activated state of the muscarinic receptor type 1

Keywords: FRET; GPCR; Gq coupling; Muscarinic receptor type 1; GPCR; G protein coupled receptor; M1R; muscarinic receptor type 1; FRET; fluorescence resonance energy transfer; FPs; fluorescent proteins; i3; intracellular third loop; HT; Halotag; Kir2.1; inward rect

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

CaV1.2 signaling complexes in the heart

Keywords: LTCC; L-type Ca2 + channel; βAR; β-adrenergic receptor; EPR; E type prostaglandin receptor; RyR2; type 2 ryanodine receptor; AC; adenylyl cyclase; PDE; phosphodiesterase; PP; protein phosphatase; AKAP; A kinase anchoring protein; PKA; protein kinase A;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Effects of the Ras homolog Rhes on Akt/protein kinase B and glycogen synthase kinase 3 phosphorylation in striatum

Keywords: GPCR; G protein-coupled receptor; GSK3; glycogen synthase kinase-3; LiCl; lithium chloride; PKA; protein kinase A; TMR; transmembrane receptors; PP2A; protein phosphatase 2A; Rhes; Ras Homolog Enriched in Striatum; dopamine; lithium; G protein; striatum;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

How adenylate cyclase choreographs the pas de deux of the receptors heteromerization dance

Keywords: AC; adenylate cyclase; A2AR; Adenosine A2A receptor; cAMP; cyclic adenosine monophosphate; CK; casein kinase; D1R; Dopamine D1 receptor; D2R; Dopamine D2 receptor; D4R; Dopamine D4 receptor; GPCR; G-protein coupled receptors; LMs; linear motifs; MoREs; mo

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents

Keywords: lipid raft; receptor; Kv7/M current; modulation; specificity; B2R; bradykinin receptor; BK; bradykinin; DRG; dorsal root ganglion; EC50; 50% effective concentration; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol tetraacetic acid; GPCR; G pr

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Activation of Mas oncogene-related gene (Mrg) C receptors enhances morphine-induced analgesia through modulation of coupling of μ-opioid receptor to Gi-protein in rat spinal dorsal horn

Keywords: ANOVA; analysis of variance; DRG; dorsal root ganglia; EDTA; ethylenediaminetetraacetic acid; GPCR; (G protein)-coupled receptor; MOR; μ-opioid receptor; MPE; maximum possible effect; Mrg; Mas oncogene-related gene; PB; phosphate buffer; PBS; phosphate-b

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibition of monocyte chemotaxis by VB-201, a small molecule lecinoxoid, hinders atherosclerosis development in ApoE−/− mice

Keywords: Chemotaxis; Inflammation; Lecinoxoids; Oxidized phospholipids; DC; dendritic cell; FACS; fluorescence-activated cell sorting; GPCR; G-protein coupled receptor; LDL; low density lipoprotein; MCP-1; monocyte chemotactic protein-1; OxPL; oxidized phospholipi

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

MAPK/NF-κB-dependent upregulation of kinin receptors mediates airway hyperreactivity: A new perspective for the treatment

Keywords: AHR; airway hyperreactivity; CaD; caldesmon; ERK1/2; extracellular signal regulated kinases 1 and 2; GPCR; G-protein coupled receptor; hMo-DCs; human monocyte-derived dendritic cells; ILs; interleukins; IKK; IκB kinase; JNK; c-Jun N-terminal kinase; LPS;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Emerging opportunities for allosteric modulation of G-protein coupled receptors

Keywords: GPCR; G-protein coupled receptor; ß2-AR; ß2-adrenoceptor; ß1-AR; ß1-adrenoceptor; A2a-AR; A2a- adenosine receptor; CXCR4; CXCR4 chemokine receptor; D3R; dopamine 3 receptor; H1R; histamine 1 receptor; M2R; M2 muscarinic receptor; M3R; M3 muscarinic re

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Potentiation of mGlu7 receptor-mediated glutamate release at nerve terminals containing N and P/Q type Ca2+ channels

Keywords: mGlu7 receptor; Glutamate release potentiation; N and P/Q Ca2+ channels; Hippocampal nerve terminal; Cerebrocortical nerve terminals; N-type Ca2+ channel KO mice; mGlu7 receptor; metabotropic glutamate receptor 7; l-AP4; L(+) phosphonobutyrate; PLC; phosp

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

The two faces of the pharmacological interaction of mGlu2 and 5-HT2A - Relevance of receptor heterocomplexes and interaction through functional brain pathways

Keywords: G-protein coupled receptor; GPCR; Metabotropic glutamate receptor 2 (mGlu2); 5-Hydroxytryptamine receptor 2A (5-HT2A); Heteromerization; Functional receptor interaction; Receptor cross-talk; Schizophrenia; 5-HT; 5-hydroxytryptamine; 5-HT2A; serotonin rece

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه