دانلود مقالات ISI درباره Gpcr + ترجمه فارسی

Rice heterotrimeric G-protein alpha subunit (RGA1): In silico analysis of the gene and promoter and its upregulation under abiotic stress

Keywords: Abiotic stress; Heterotrimeric G-proteins; Metals; Real-time PCR; Rice G-protein α subunits; Signal transduction; ABA; abscisic acid; ARE; auxin responsive elements; Gα; G-protein α subunits; GPCR; G-protein coupled receptor; RGA(I); α subunit of Ind

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Sphingosine-1-phosphate receptor-2 mediated NFκB activation contributes to tumor necrosis factor-α induced VCAM-1 and ICAM-1 expression in endothelial cells

Keywords: S1P; sphingosine-1-phosphate; GPCR; G-protein coupled receptor; S1P1-5; high affinity GPCRs for S1P; TNFα; tumor necrosis factor-α; VCAM-1; vascular cell adhesion molecule 1; ICAM-1; intercellular adhesion molecule 1; SphK; sphingosine kinase; HUVEC;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Docking and MD study of histamine H4R based on the crystal structure of H1R

Keywords: Histamine; GPCR; Docking; Molecular dynamics; Drug design

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

The role of the neuropeptide S system in addiction: Focus on its interaction with the CRF and hypocretin/orexin neurotransmission

Keywords: NPS; neuropeptide S; NPSR; neuropeptide S receptor; CRF; corticotrophin releasing factor; Hcrt-1/Ox-A; hypocretin-1/orexin-A; GPR154; G protein coupled receptor 154; ppNPS; prepropeptide NPS; Lys-Arg; lysine-arginine; mRNA; messenger RNA; LC; locus co

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Sulfur-containing amino acids in 7TMRs: molecular gears for pharmacology and function

Keywords: GPCR; crystal structure; site-directed mutagenesis; molecular modeling

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

CB1 cannabinoid receptors promote maximal FAK catalytic activity by stimulating cooperative signaling between receptor tyrosine kinases and integrins in neuronal cells

Keywords: 2-AG; 2-arachidonoylglycerol; BSA; bovine serum albumin; CB1; CB1 cannabinoid receptor; Csk; C-terminal Src kinase; DAGL; diacylglycerol lipase; DTT; dithiothreitol; ECM; extracellular matrix; ERK1/2; extracellular signal-regulated kinases 1 and 2; EGFR;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold

Keywords: TGR5; GPCR; Diabetes; 4-Phenyl pyridine

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Mastering tricyclic ring systems for desirable functional cannabinoid activity

Keywords: Cannabinoid; CB2; GPCR; Neuropathic pain; Carbazole; CB1BSA, bovine serum albumin; CB1, cannabinoid receptor 1; CB2, cannabinoid receptor 2; EC50, half maximal effective concentration; EDTA, ethylenediaminetetraacetic acid; GTP, guanosine-5′-triphosphate;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2013 سفارش ترجمه

Vitamin D in thyroid tumorigenesis and development

Keywords: 1,25(OH)2D3; 1α,25-dihydroxyvitamin D3; 25-OHD3; 25-hydroxyvitamin D3; ATC; anaplastic thyroid cancer; CDK; cyclin-dependent kinase; CDKI; cyclin-dependent kinase inhibitor; CEA; carcinoembryogenic antigen; CT; calcitonin; CYP24A1; 24-hydroxylase; CYP27B

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2013 سفارش ترجمه

Spatial arrangement of rhodopsin in retinal rod outer segment membranes studied by spin-labeling and pulsed electron double resonance

Keywords: Rhodopsin arrangement; GPCR; Rod outer segment; Spin labeling; PELDOR;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Mini-review: The evolution of neuropeptide signaling

Keywords: Adipokinetic hormone; Corazonin; GnRH; GPCR; Neuropeptide; Evolution

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of S-777469: An orally available CB2 agonist as an antipruritic agent

Keywords: Cannabinoid; CB receptor agonist; GPCR; Antipruritics

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists

Keywords: CCR2; CCR2 antagonist; Chemokine antagonist; GPCR; Benzimidazole;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

N-Amino acid linoleoyl conjugates: Anti-inflammatory activities

Keywords: EMA; elmiric acids; GPCR; G-protein coupled receptor; LXA4; lipoxin A4; LINgly; N-linoleoylglycine; LINphe; N-linoleoylphenylalanine; LINtyr; N-linoleoyltyrosine; NAgly; N-arachidonoylglycine; PALgly; palmitoylglycine; PGJ; 15-deoxy-Δ13,14-PGJ2; Elmiric

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors

Keywords: Opioid-induced hyperalgesia; NPFF receptors; Pain; Dipeptidic ligand; GPCR;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Hit to lead SAR study on benzoxazole derivatives for an NPY Y5 antagonist

Keywords: Obesity; NPY Y5 receptor antagonist; GPCR; Benzoxazole; Hit to lead;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism

Keywords: CRTH2; DP; PGD2; GPCR; Antagonist; Asthma; Allergic diseases; Lead optimization; SAR;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Optimization of phenylacetic acid derivatives for balanced CRTH2 and DP dual antagonists

Keywords: CRTH2; DP; PGD2; GPCR; Dual Antagonist; SAR; Asthma

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain

Keywords: mGluR1 (metabotropic glutamate receptor 1); Neuropathic pain; Spinal nerve ligation (SNL); Fused tricyclic pyridones; GPCR

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2)

Keywords: CCR2; Chemokine; GPCR; Antagonist

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of S-444823, a potent CB1/CB2 dual agonist as an antipruritic agent

Keywords: Cannabinoid; CB receptor agonist; GPCR; Antipruritics

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

CB 1/2 dual agonists with 3-carbamoyl 2-pyridone derivatives as antipruritics: Reduction of CNS side effects by introducing polar functional groups

Keywords: Cannabinoid; CB receptor agonist; GPCR; Antipruritics

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Negative feedback regulation of Gq signaling by protein kinase C is disrupted by diacylglycerol kinase ζ in COS-7 cells

Keywords: PI cycle; phosphatidylinositol cycle; Diacylglycerol kinase; Gq; GPCR; Phosphatidic acid; Phospholipase C-β; Protein kinase C;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

G-protein-coupled receptor GPR21 knockout mice display improved glucose tolerance and increased insulin response

Keywords: CRP; C reactive protein; IP-10; interferongamma-induced protein 10; MCP-1; monocyte chemotactic protein-1; SAP; serum amyloid protein; GPCR; Knockout mice; Obesity; Type 2 diabetes; GPR21; Metabolic inflammation;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

CCL3 induced migration occurs independently of intracellular calcium release

Keywords: CHO; Chinese hamster ovary; DMEM; Dulbecco's modified eagle's medium; EDTA; ethylenediaminetetraacetic acid; FCS; foetal calf serum; GPCR; G protein coupled receptor; GRK; G-protein coupled receptor kinase; PBS; phosphate buffered saline; PKC; protein

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Effective expression of human proteins on bacterial magnetic particles in an anchor gene deletion mutant of Magnetospirillum magneticum AMB-1

Keywords: M. magneticum AMB-1; Magnetospirillum magneticum AMB-1; BacMP; bacterial magnetic particle; Δmms13; mms13 deletion mutant; TSHR; thyroid-stimulating hormone receptor; MHC; major histocompatibility complex; MSGM; magnetic spirillum growth medium; GPCR; G

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Removal of sphingomyelin headgroup inhibits the ligand binding function of hippocampal serotonin1A receptors

Keywords: 5-HT1A receptor; 5-hydroxytryptamine-1A receptor; 8-OH-DPAT; 8-hydroxy-2(di-N-propylamino)tetralin; BCA; bicinchoninic acid; DMPC; dimyristoyl-sn-glycero-3-phosphocholine; DPH; 1,6-diphenyl-1,3,5-hexatriene; GPCR; G-protein coupled receptor; PMSF; phenylm

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Chimeric relaxin peptides highlight the role of the A-chain in the function of H2 relaxin

Keywords: Relaxin; RXFP1; GPCR; Peptide;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists

Keywords: Orexin; GPCR; Addiction;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Molecular modeling study of cyclic pentapeptide CXCR4 antagonists: New insight into CXCR4–FC131 interactions

Keywords: FC131; CXCR4; GPCR; Docking; Molecular modeling

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Minority of mammalian orthologs can be regarded as physiologically closest genes

Keywords: Blosum; blocks of amino acid substitution matrix; C2H2; cysteine(2)histidine(2); COG; clusters of orthologous groups; dN; distance of nonsynonymous substitutions; dS; distance of synonymous substitutions; GPCR; G-protein-coupled receptor; InterPro; integr

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Neuroendocrine signalling: Natural variations on a Ca2+ theme

Keywords: AVP; arginine vasopressin; OT; oxytocin; SON; supraoptic nucleus; [Ca2+]i; cytosolic Ca2+ transients/increase; CPA; cyclopiazonic acid; TG; thapsigargin; CCCP; carbonyl cyanide 3-chlorophenylhydrazone; ER; endoplasmic reticulum; SERCA; sarcoendoplasmic re

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Fluorescence resonance energy transfer-based technologies in the study of protein-protein interactions at the cell surface

Keywords: FRET; Protein-protein interactions; Cell surface; GPCR; TIRF; SNAP; TR-FRET;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone

Keywords: Chemokine; GPCR; CCR2; Isostere;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Frizzled7 as an emerging target for cancer therapy

Keywords: ALL; Acute lymphoblastic leukemia; APC; Adenomatous polyposis coli; CamKII; Calmodulin kinase II; Cthrc1; Collagen triple helix repeat containing protein; CK1; Caseine kinase 1; CTNNB1; β-catenin gene; CRD; Cysteine rich domain; CSC; Cancer stem cells; D

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile

Keywords: GPR119; GPCR; Diabetes; Lead optimization

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

In vivo impact of prodrug isosorbide-5-nicotinate-2-aspirinate on lipids and prostaglandin D2: Is this a new immediate-release therapeutic option for niacin?

Keywords: ApoB; apolipoprotein B; AUC; area under the curve; BuChE; butyrylcholinesterase; COX; cyclooxygenase; SR; sustained release; ER; extended release; GPCR; G-protein coupled receptor; HDL-C; high density lipoprotein cholesterol; IR; immediate-release; LDL-C;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development

Keywords: mGluR5; Negative allosteric modulator; GPCR; In vitro pharmacology; Pain; Clinical candidate;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Constitutive internalization and recycling of metabotropic glutamate receptor 5 (mGluR5)

Keywords: Endocytic trafficking; Recycling; GPCR; Metabotropic glutamate receptor; Glutamate; Neurotransmitter receptor

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis

Keywords: GPCR; G protein-coupled receptor; GRK; GPCR kinase; GIT; GRK-interacting protein; ARF-GAPs; ADP-ribosylation factor GTPase-activating proteins; GEF; guanine nucleotide exchange factor; MSC; mesenchymal stem cell; qCT; quantitative micro-computed tomograph

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

GRK5 deficiency decreases diet-induced obesity and adipogenesis

Keywords: ANOVA; analysis of variance; GPCR; G protein-coupled receptor; GRK; GPCR kinase; KO; knockout; SD; standard diet; HFD; high fat diet; WAT; white adipose tissue; MEF; mouse embryonic fibroblast; SVF; stromal vascular fraction cell; PPARγ; peroxisome pro

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Nucleobindins: Bioactive precursor proteins encoding putative endocrine factors?

Keywords: Nucleobindin; Nesfatin-1; Brain; GPCR; Hormone

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

The role of cholesterol on the activity and stability of neurotensin receptor 1

Keywords: Neurotensin; GPCR; Cholesterol; Reconstitution; POPE; FRET

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Chemokine receptor oligomerization: A further step toward chemokine function

Keywords: Chemokine receptors; Oligomerization; GPCR

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

All G protein βγ complexes are capable of translocation on receptor activation

Keywords: GPCR; G protein; Live cell imaging; Translocationl GIRK channel

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Short CommunicationTranscriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A2A and metabotropic glutamate type 5 receptors: Focus on beta-synuclein expression

Keywords: GPCR; G protein-coupled receptor; CNS; central nervous system; GABA; gamma-aminobutyric acid; A2AR; adenosine A2A receptor; D2R; dopamine D2 receptor; mGlu5R; metabotropic glutamate type 5 receptor; RET; resonance energy transfer; PKA; protein kinase A; M

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Research reportInvolvement of GPR12 in the induction of neurite outgrowth in PC12 cells

Keywords: FGF; fibroblast growth factor; NGF; nerve growth factor; cAMP; cyclic AMP; PKA; protein kinase A; GPCR; G protein-coupled receptor; SYP; synaptophysin; MAP-2; microtubule-associated protein-2; GPR12; Phosphor-Erk1/2; Synaptophysin; Bcl-xL; Bcl-2;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Membrane cholesterol stabilizes the human serotonin1A receptor

Keywords: 5-HT1A receptor; 5-hydroxytryptamine-1A receptor; 8-OH-DPAT; 8-hydroxy-2(di-N-propylamino)tetralin; BCA; bicinchoninic acid; BSA; bovine serum albumin; CAPS; 3-[cyclohexylamino]-1-propanesulfonic acid; CCM; cholesterol consensus motif; CRAC; cholesterol r

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Synergism by individual macronutrients explains the marked early GLP-1 and islet hormone responses to mixed meal challenge in mice

Keywords: GPCR; G-Protein coupled receptors; GLP-1; Glucagon-like peptide 1; sAUC; Suprabasal area under the curve; tAUC; Total area under the curve; QUICKI; Quantitative insulin sensitivity check index; OGIS; Oral glucose insulin sensitivity index; Macronutrients;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling

Keywords: Smo; smoothened; Hh; hedgehog; Ptc; patched; Shh; sonic hedgehog; β arr2; β-arrestin2; β arr2-GFP; β-arrestin2-green fluorescent protein chimera; Gli; glioma-associated oncogene; GPCR; G-protein-coupled receptor; V2R; vasopressin2 receptor; HTS; high-

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه