دانلود مقالات ISI درباره Gpcr + ترجمه فارسی

Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate

Keywords: NK; neurokinin; SP; substance P; GPCR; G protein-coupled receptor; CNS; central nervous system; SAD; social anxiety disorders; CINV; chemotherapy-induced nausea and vomiting; PoC; prove of concept; SAR; structure-activity relationship; CDI; carbonyldiim

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Rho participates in chemoreceptor-induced changes in morphology to hair bundle mechanoreceptors of the sea anemone, Nematostella vectensis

Keywords: BSA; bovine serum albumin; CN; calcineurin; CaM-kinase; calmodulin-dependent kinase; GDI; GDP dissociation inhibitor; GEF; guanine nucleotide exchange factor; GPCR; G-protein coupled receptors; IP3; inositol 1,4,5-triphosphate; KSW; high potassium seawate

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Modulation of low-voltage-activated T-type Ca2 + channels

Keywords: LVA; low-voltage-activated; HVA; high-voltage-activated; T-type channels; T-type Ca2 + channels; cAMP; cyclic adenosine monophosphate; PKA; protein kinase A; PKC; protein kinase C; PKG; protein kinase G; PTK; protein tyrosine kinase; HEK293; human embryo

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Oxysterols modulate calcium signalling in the A7r5 aortic smooth muscle cell-line

Keywords: Oxysterol; Smooth muscle; Calcium; Inositol 1,4,5-trisphosphate receptor; Ryanodine receptor; Atherosclerosis; 4-CMC; 4-chloro-meta-cresol; 7β-OH; 7β-hydroxycholesterol; 7-keto; 7-ketocholesterol; 25-OH; 25-hydroxcholesterol; AVP; arginine vasopression;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Gastrointestinal hormones stimulate growth of Foregut Neuroendocrine Tumors by transactivating the EGF receptor

Keywords: Bn; bombesin; EGFR; epidermal growth factor receptor; GI; gastrointestinal; GPCR; G protein coupled receptor; HNSCC; head and neck squamous cell cancers; MMP; matrix metalloproteinases; NETs; neuroendocrine tumors; NT; neurotensin; PETs; pancreatic endocr

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Mechanisms of conotoxin inhibition of N-type (Cav2.2) calcium channels

Keywords: N-type VGCC; neuronal-type voltage-gated calcium channel; CDI; Ca2 +-dependent inactivation; GPCR; G protein-coupled receptor; GABA; γ-aminobutyric acid; GABABR; GABAB receptor; siRNA; small interfering RNA; VFT; Venus flytrap module; nAChR; nicotinic a

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Angiotensin AT2 receptor activates the cyclic-AMP signaling pathway in eel

Keywords: ATIP; AT2 receptor interacting protein; CRE; cAMP-responsive element; DIG; digoxigenin; GC; guanylyl cyclase; GPCR; G-protein coupled receptor; HEK293; human embryonic kidney cell line 293; KT5823; 2,3,9,10,11,12-hexahydro-10R-methoxy-2,9-dimethyl-1-oxo-9

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

The heterodimerization of platelet-derived chemokines

Keywords: MD; molecular dynamics; ESI-MS; electrospray ionization mass spectrometry; co-IP; co-immunoprecipitation; Western Blot; WB; SPR; surface plasmon resonance; Mr; molecular weight; NMR; nuclear magnetic resonance spectroscopy; PDB; Protein Data Bank; ACN; ac

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors

Keywords: AC; adenylyl cyclase; βAR; β-adrenergic receptor; αAR; α-adrenergic receptor; ATP; adenosine triphosphate; cET-1; caged ET-1; cGMP; cyclic guanosine 3′,5′-monophosphate; CYP; cyanopindolol; DAF-2; diaminofluorescein-2; DNA; deoxyribonucleic acid;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Functional properties of cell-free expressed human endothelin A and endothelin B receptors in artificial membrane environments

Keywords: Aso-PC; soybean l-α-phosphatidylcholine; BTE; brain total extract; CECF; continuous exchange cell-free; CF; cell-free; CHS; cholesteryl hemisuccinate; CVs; column volumes; DMPC; 1,2-dimyristoyl-sn-glycero-3-phosphocholine; DMPG; 1,2-dimyristoyl-sn-glycer

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

8-(2-Furyl)adenine derivatives as A2A adenosine receptor ligands

Keywords: Purinergic receptors; Adenosine receptors; Adenosine receptor antagonists; Adenine derivatives; Purine derivatives; Molecular modelling; AR; adenosine receptor; GPCR; G protein-coupled receptor; CNS; central nervous system; DMF; dimethylformamide; NBS; N-

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Endogenous lipid activated G protein-coupled receptors: Emerging structural features from crystallography and molecular dynamics simulations

Keywords: MD; molecular dynamics; 2-AGPI; 2-arachidonoyl-sn-glycero-3-phosphoinositol; POPC; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; AEA; N-arachidonoylethanolamine; TMH; transmembrane helix; GPCR; G protein-coupled receptor; EDG; endothelial differentiat

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

G protein-coupled receptor quantification using peptide group-specific enrichment combined with internal peptide standard reporter calibration

Keywords: 5-HT; 5-hydroxytryptamine (serotonin); ESI; electrospray ionization; GPCR; G-protein coupled receptor; IPA; isopropyl alcohol; iTRAQ®; isobaric tag for relative and absolute quantification; LC-MS; liquid chromatography-mass spectrometry; LLOD; lower

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

PI3Kγ inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis mice

Keywords: DMSO; dimethyl sulfoxide; EAE; experimental autoimmune encephalomyelitis; GPCR; GTP-binding protein-coupled receptor; KO; knockout; LFB; Luxol fast blue; MBP; myelin basic protein; MOG; myelin oligodendrocyte glycoprotein; MS; multiple sclerosis; NF; neur

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Functional selectivity induced by mGlu4 receptor positive allosteric modulation and concomitant activation of Gq coupled receptors

Keywords: Glutamate; Histamine; Receptor; Allosteric modulator; Functional selectivity; mGlu receptor; metabotropic glutamate receptor; CHO; Chinese Hamster Ovary; DHFR(−); Dihydrofolate Reductase; DMSO; Dimethyl Sulfoxide; GPCR; G-Protein-Coupled Receptor; 7TMR;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

5-HT1A receptors transactivate the platelet-derived growth factor receptor type beta in neuronal cells

Keywords: 5-HT; 5-hydroxytryptamine, serotonin; 5-CT; 5-carboxamidotryptamine; PDGF; platelet-derived growth factor; PLC; phospholipase C; Ptx; pertussis toxin; GPCR; G protein-coupled receptor; ERK; extracellular signal-regulated kinase; EGTA; ethylene glycol tetr

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Receptor-mediated Ca2 + and PKC signaling triggers the loss of cortical PKA compartmentalization through the redistribution of gravin

Keywords: AKAP; A-Kinase Anchoring Protein; ATP; adenosine triphosphate; β2AR; β2-adrenergic receptor; BAPTA-AM; 1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester); BIM; bisindolylmaleimide; [Ca2 +]i; intracellular calcium

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

A novel homology model of TRPC3 reveals allosteric coupling between gate and selectivity filter

Keywords: BAPTA; 1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid; GPCR; G protein coupled receptor; PLC; phospholipase C; DAG; diacylglycerol; SAG; 1-stearoyl-2-arachidonoyl-sn-glycerol; TRPC3; Homology modeling; Selectivity; Gating;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Epithelial G protein-coupled receptor kinases regulate the initial inflammatory response during mycobacterial infection

Keywords: GPCR; G protein-coupled receptors; GRK; G protein-coupled receptor kinase; LAM; lipoarabinomannan; PI-3K; phosphoinositide 3-kinases; ERK; extracellular signal-regulated kinase; Akt; serine/threonine protein kinase; COPD; chronic obstructive pulmonary dis

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

The three α1-adrenoceptor subtypes show different spatio-temporal mechanisms of internalization and ERK1/2 phosphorylation

Keywords: α1-AR; α1 adrenoceptor; β2-AR; β2 adrenoceptor; AT1AR; angiotensin receptor type 1A; Bmax; maximum number of binding sites; BSA; bovine serum albumin; ConA; concanavalin A; DMSO; dimethyl sulfoxide; EGFR; epidermal growth factor receptor; GAPDH; glyce

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Comparative genomic analysis and evolution of family-B G protein-coupled receptors from six model insect species

Keywords: GPCR; G protein-coupled receptor; GPCR-Bs; family-B GPCRs; PTHRL; parathyroid hormone receptor-like; TM; transmembrane domain; Boss; bride of sevenless; CRF; corticotropin releasing factor; PDF; pigment dispersing factor; DH; diuretic hormone; CIRL; calci

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Expression, surface immobilization, and characterization of functional recombinant cannabinoid receptor CB2

Keywords: CB2; peripheral cannabinoid receptor; GPCR; G protein-coupled receptor; MBP; maltose binding protein; NTA; nitrilotriacetic acid; SPR; surface plasmon resonance; TEV; tobacco etch virus; CHS; cholesteryl hemisuccinate Tris salt; CHAPS; 3[(cholamidopropyl)

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Structural features of the apelin receptor N-terminal tail and first transmembrane segment implicated in ligand binding and receptor trafficking

Keywords: AR; apelin receptor; AR55; residues 1-55 of AR; BSA; bovine serum albumin; CSI; chemical shift index; DMEM; Dulbecco's modified eagle medium; DPC; dodecylphosphocholine; DPPC; dipalmitoylphosphatidylcholine; DSS; sodium 2,2-dimethyl-2-silapentane-5-sulf

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Structural and functional differences between pheromonotropic and melanotropic PK/PBAN receptors

Keywords: CAPA-DH; capa-gene-derived peptide; DH; diapause hormone; ECL; extra-cellular loop; GPCR; G-protein-coupled receptor; ICL; intra-cellular loop; Np; neuropeptide; PI; pre-immune serum; PK/PBAN; pyrokinin/pheromone biosynthesis-activating neuropeptide; PK/P

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Neu1 sialidase and matrix metalloproteinase-9 cross-talk regulates nucleic acid-induced endosomal TOLL-like receptor-7 and -9 activation, cellular signaling and pro-inflammatory responses

Keywords: TLR; TOLL-like receptors; 4MUNANA; 2′-(4-methylumbelliferyl)-α-d-N-acetylneuraminic acid; Tamiflu; oseltamivir phosphate; MMP; matrix metalloproteinase; GPCR; G-protein coupled receptor; SEAP; secreted embryonic alkaline phosphatase; IC50; 50% inhibito

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

CCL5/CCR1 axis regulates multipotency of human adipose tissue derived stromal cells

Keywords: ADSCs; adipose tissue derived stromal cells; BCs; peripheral blood mononuclear cells; BMSCs; bone marrow derived stromal cells; ESCs; embryonic stem cells; GPCR; G-protein coupled receptor; p; passage;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

The NMDA receptor as a target for cognitive enhancement

Keywords: Synaptic plasticity; NMDA receptor; Cognitive enhancement; LTP; Synaptic transmission; Hippocampus; Positive allosteric modulators; AChR; acetylcholine receptor; AKAP79/150; A-kinase anchoring proteins; AMPAR; AMPA receptor; CaMKII; Ca2+/calmodulin-depend

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

IP3, a small molecule with a powerful message

Keywords: ANT; adenine nucleotide translocator; ATP; adenosine triphosphate; BBB; blood-brain barrier; Bcl-2; B-cell lymphoma-2; BH; Bcl-2-homology domain; BI-1; Bax-inhibitor-1; [Ca2 +]i; cytoplasmic Ca2 + concentration; cAMP; cyclic adenosine monophosphate; cGM

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor

Keywords: 12-HHT; 12-hydroxy-5Z,8E,10E-heptadecatrienoic acid; 5,12-diHETE; 5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid; 5,15-diHETE; 5S,15S-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid; 5-HEDH; 5-hydroxyeicosanoid dehydrogenase; 5-HEPE; 5S-hydroxy-6E,8Z,

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Desensitization of human CRF2(a) receptor signaling governed by agonist potency and βarrestin2 recruitment

Keywords: CK1; casein kinase 1; CK2; casein kinase 2; CRF1 receptor; CRF receptor type 1; CRF2(a) receptor; CRF receptor type 2(a); K44A; dynamin dominant negative mutant; GPCR; G protein-coupled receptor; GRK; GPCR kinase; PKA; protein kinase A; PKC; protein kinas

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

The time course of serotonin 2C receptor expression after spinal transection of rats: An immunohistochemical study

Keywords: 5-HT; serotonin; 5-HT2AR; serotonin 2A receptor; 5-HT2BR; serotonin 2B receptor; 5-HT2CR; serotonin 2C receptor; BSA; bovine serum albumin; ChAT; choline acetyltransferase; DOI; 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane; GPCR; G-protein-coupled recept

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Pertussis toxin-sensitive heterotrimeric Gαi/o proteins mediate WNT/β-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A

Keywords: Frizzled; GPCR; Heterotrimeric G protein; Canonical WNT signaling; Microglia; Neuroinflammation;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2013 سفارش ترجمه

Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks

Keywords: ARF; ADP-ribosylation factor; DAG; diacylglycerol; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; FAPP2; Four-phosphate adaptor protein 2; FAAT motif; two phenylalanines in an acidic tract motif; GPCR; G-p

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2013 سفارش ترجمه

PACAP induces the dimerization of PAC1 on the nucleus associated with the cAMP increase in the nucleus

Keywords: PACAP; PAC1; GPCR; Dimerization; Nuclear;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery of a potent, selective, and orally bioavailable histamine H3 receptor antagonist SAR110068 for the treatment of sleep–wake disorders

Keywords: Histamine H3 receptor antagonist/inverse agonist; GPCR; Awakening; EEG; Neurotransmitters (acetylcholine, noradrenaline, dopamine, GABA and serotonin)

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

A hydrophobic site on the GLP-1 receptor extracellular domain orients the peptide ligand for signal transduction

Keywords: GLP-1; Exendin-4; Glucagon; GPCR; Receptor activation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Peptide backbone modifications on the C-terminal hexapeptide of neurotensin

Keywords: Neurotensin; GPCR; Backbone modifications; Peptide analogues; Ligand binding; Pharmacophore model; NT(8-13)

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Detection of ligand–receptor binding using microfluidic frontal affinity chromatography on proteoliposomes derived directly from native cell membranes

Keywords: Microfluidics; Frontal affinity chromatography; Ligand–receptor binding; GPCR; Mass spectrometry

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

A novel series of N-(azetidin-3-yl)-2-(heteroarylamino)acetamide CCR2 antagonists

Keywords: CCR2 inhibitor; Monocyte chemoattractant protein-1; MCP-1; CCL2; CCR2; Chemokine antagonist; CCR2 antagonist; GPCR

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Bitter taste receptor research comes of age: From characterization to modulation of TAS2Rs

Keywords: Bitter taste perception; TAS2R; GPCR

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Arrayed antibody library technology for therapeutic biologic discovery

Keywords: CDR; complementary determining region; mAb; monoclonal antibody; V; variable; D; diversity; J; joining; GPCR; G-protein coupled receptor; CVB; culture vessel block; LIMS; laboratory information management system; Fab; fragment antigen-binding; SAR; struct

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Suppression of adenylyl cyclase-mediated cAMP production by plasma membrane associated cytoskeletal protein 4.1G

Keywords: AGS; activator of G protein-signaling; cAMP; cyclic adenosine monophosphate; CTD; carboxy-terminal domain; DMEM; Dulbecco's modified Eagle's medium; EMEM; Eagle's minimum essential medium; Epac; exchange protein activated by cAMP; ERK; extracellular signa

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Frizzled receptors signal through G proteins

Keywords: Frz, frizzled; GPCR, G protein-coupled receptor; MAPK, mitogen-activated protein kinase; GEF, guanine nucleotide exchange factor; GDI, guanine nucleotide dissociation inhibitorFrizzled; G protein; GPCR; Wnt signaling; Planar cell polarity; GDI

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

α1-Adrenoceptor and serotonin 5-HT1A receptor affinity of homobivalent 4-aminoquinoline compounds: An investigation of the effect of linker length

Keywords: GPCR; α1-Adrenergic receptor; Subtype selectivity; Serotonin receptor; Diquinoline; Linker length

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Polymorphisms and genetic linkage of histamine receptors

Keywords: GPCR; Histamine; Genetic; Polymorphism; Diseases

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Characterisation of a functional allatotropin receptor in the bumblebee, Bombus terrestris (Hymenoptera, Apidae)

Keywords: AT; ATR; GPCR; Invertebrate; Neuropeptide; Orexin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Vertebrate extracellular calcium-sensing receptor evolution: Selection in relation to life history and habitat

Keywords: CaSR; calcium-sensing receptor; CRD; cysteine-rich domain; ECD; extracellular domain; GABABR; γ-aminobutyric acid type B receptor; GPCR; G protein-coupled receptor; ICD; intracellular domain; LRT; likelihood ratio test; MAP; mitogen-activated protein (ki

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Identification, structural and pharmacological characterization of τ-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor

Keywords: Conopeptide; Conus consors; Somatostatin sst3 receptor; T-conotoxin; GPCR

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Regulation of the Hippo pathway and implications for anticancer drug development

Keywords: Hippo pathway; YAP; phosphorylation; GPCR; cancer

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

The adenosine A2A antagonistic properties of selected C8-substituted xanthines

Keywords: Adenosine A2A receptors; Antagonism; Xanthine; Haloperidol-induced catalepsy; Parkinson's disease; CNS; central nervous system; CPA; cyclopentyladenosine; CSC; (E)-8-(3-chlorostyryl)caffeine; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide; EDAC; N

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه