دانلود مقالات ISI درباره Gpcr + ترجمه فارسی

Ligand based design of novel histamine H4 receptor antagonists; fragment optimization and analysis of binding kinetics

Keywords: Histamine; H4R antagonist; GPCR; Binding kinetics; Fragment optimization; GPCRs; G protein-coupled receptors; H1R; histamine H1 receptor; H2R; histamine H2 receptor; H3R; histamine H3 receptor; H4R; histamine H4 receptor; SAR; structure-activity relatio

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Inositol 1,4,5-trisphosphate receptors and pacemaker rhythms

Keywords: 2-APB; aminoethoxydiphenyl borate; CICR; Ca2+-induced Ca2+ release; ET-1; endothelin‐1; GPCR; G-protein coupled receptors; HCN4; the hyperpolarization-activated, cyclic nucleotide-gate cation channels 4; IP3R; inositol 1,4,5-trisphosphate receptor; PLC;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

The predicted N-terminal signal sequence of the human α2C-adrenoceptor does not act as a functional cleavable signal peptide

Keywords: Signal peptide; N-tail; α2C-Adrenoceptor; GPCR; Translocation;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Optimization of purification and refolding of the human chemokine receptor CXCR1 improves the stability of proteoliposomes for structure determination

Keywords: DHPC; 1,2-dihexanoyl-sn-glycero-3-phosphocholine; DMPC; 1,2-dimyristoyl-sn-glycero-3-phosphocholine; DPC; dodecylphosphocholine; GST; glutathione S-transferase; HEPES; 4-(2-hydroxyethyl)-1 piperazineethane-sulfonic acid; HPC; n-hexadecylphosphocholine; MÎ

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Sweeteners interacting with the transmembrane domain of the human sweet-taste receptor induce sweet-taste synergisms in binary mixtures

Keywords: GPCR; G protein-coupled receptor; hT1R; human T1R; NHDC; neohesperidin dihydrochalcone; TMD; transmembrane domain; VFTM; Venus flytrap module; WT; wild-type; T1R2/T1R3; Sweet synergism; Taste receptor; Calcium imaging; NHDC; Cyclamate;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Regulation of endocannabinoid release by G proteins: A paracrine mechanism of G protein-coupled receptor action

Keywords: Endocannabinoid; CB1; GPCR; Angiotensin II;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Skeletal tissues in Mozambique tilapia (Oreochromis mossambicus) express the extracellular calcium-sensing receptor

Keywords: CaSR; calcium-sensing receptor; EC50; effective concentration producing a 50% response; CRD; cysteine-rich domain; ECD; extracellular domain; GPCR; G protein-coupled receptor; ICD; intracellular domain; IHC; immunohistochemistry; RT-PCR; reverse transcrip

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Research ReportProconvulsive effects of oxytocin in the generalized pentylenetetrazol mouse model are mediated by vasopressin 1a receptors

Keywords: OT; oxytocin; AD; antidepressant; OTR; oxytocin receptor; GPCR; G protein coupled-receptor; i.v.; intravenous; s.c.; subcutaneous; i.p.; intraperitoneal; PTZ; pentylenetetrazol; CBT; carbetocin; V1aR; vasopressin 1a receptor; AVP; arginine vasopressin; PE

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Differential PKC-dependent and -independent PKD activation by G protein α subunits of the Gq family: Selective stimulation of PKD Ser748 autophosphorylation by Gαq

Keywords: PKC; protein kinase C; PKD; protein kinase D; GPCR; G protein-coupled receptor; Gα; heterotrimeric G protein alpha subunit; PLC; phospholipase C; CAMK; Ca2 +/calmodulin-dependent protein kinase; AlF4−; aluminum fluoride; GFP; enhanced green fluorescen

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

G-protein coupled receptor agonists mediate Neu1 sialidase and matrix metalloproteinase-9 cross-talk to induce transactivation of TOLL-like receptors and cellular signaling

Keywords: GPCR; G-protein coupled receptor; TLR; TOLL-like receptors; LPS; endotoxin lipopolysaccharide; pNFκB; NFκB p65 (Rel A) phosphospecific pS529; 4MUNANA; 2′-(4-methylumbelliferyl)-α-d-N-acetylneuraminic acid; poly-IC; polyinosinic-polycytidylic acid;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Intercepting neoplastic progression in lung malignancies via the beta adrenergic (β-AR) pathway: Implications for anti-cancer drug targets

Keywords: β-AR; beta-adrenergic receptors; cAMP; cyclic adenosine 3′,5′-monophosphate; CREB; cAMP response element binding protein; EGFR; epidermal growth factor receptor; GABA; gamma-aminobutyric acid; GPCR; G protein-coupled receptor; ICI; a selective beta2

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

The multi-faceted roles of prostaglandin E2 in cancer-infiltrating mononuclear phagocyte biology

Keywords: 13-PGR; Δ13-15-ketoprostaglandin reductase; 15-PGDH; 15-prostaglandin dehydrogenase; APC; adenomatous polyposis coli; BM; bone marrow; cAMP; cyclic adenosine monophosphate; cDC; conventional DC; COX; cyclooxygenase; CTL; cytotoxic lymphocyte; DC; dendrit

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of antagonists of tick dopamine receptors via chemical library screening and comparative pharmacological analyses

Keywords: Ixodes scapularis; GPCR; Dopamine receptor; Small molecule screen; LOPAC1280cAMP, cyclic adenosine monophosphate; CRE, cAMP response element; DA, dopamine; FDA, Federal Drug Administration; GPCR, G Protein-Coupled Receptor; Is, Ixodes scapularis; Luc, Luc

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

An evolutionary comparison of leucine-rich repeat containing G protein-coupled receptors reveals a novel LGR subtype

Keywords: Leucine-rich repeat containing G protein-coupled receptor; Glycoprotein hormone receptor; Evolution; FSH(R); Follicle stimulating hormone (receptor); GPCR; G protein-coupled receptor; ILP; Insulin-like peptide; LDLa; low density lipoprotein receptor-like

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Functional characterization of an allatotropin receptor expressed in the corpora allata of mosquitoes

Keywords: Mosquito; Allatrotopin; Receptor; GPCR; Juvenile hormone; Aedes;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Characterization, expression, and evolutionary aspects of Corazonin neuropeptide and its receptor from the House Fly, Musca domestica (Diptera: Muscidae)

Keywords: CNS; central nervous system; CAP; Corazonin-associated peptide; DmCrz; Drosophila melanogaster Corazonin; GPCR; G protein-coupled receptor; IHC; immunohistochemistry; ISH; in situ hybridization; MdCrz; Musca domestica Corazonin; MdCrzR; Musca domestica Co

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Artificial membrane-like environments for in vitro studies of purified G-protein coupled receptors

Keywords: GPCR; G-protein coupled receptor; SUV; small unilamellar vesicle; GUV; giant unilamellar vesicle; MSP; membrane scaffold protein; PLM; planar lipid membrane; GPCR reconstitution; Bicelle; Nanodisc; Giant unilamellar vesicle; Planar lipid membrane; Lipidic

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

S-nitrosylation-regulated GPCR signaling

Keywords: GPCR; GRK; Arrestin; Dynamin; S-nitrosylation;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Serotonin 5-HT2A receptor-mediated hypertrophy is negatively regulated by caveolin-3 in cardiomyoblasts and neonatal cardiomyocytes

Keywords: 5-HT; Serotonin; NFAT; nuclear factor of activated T cells; p42/p44 MAPK; p42/p44 mitogen activated protein kinases; siRNA; small interference RNA; ANF; atrial natriuretic factor; β-MHC; β-myosin heavy chain; GPCR; G-protein coupled receptor; TRPC1; tra

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Localization of Ras signaling complex in budding yeast

Keywords: cAMP; 3′-5′-cyclic adenosine monophosphate; GEF; guanine exchange factor; GAP; GTPase activating protein; ER; endoplasmic reticulum; PKA; protein kinase A; GPCR; G-protein coupled receptor; Saccharomyces cerevisiae; Cdc25; Ira; Adenylate cyclase; Memb

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Coordination of calcium signals by pituitary endocrine cells in situ

Keywords: ACTH; adrenocorticotrophic hormone; ATP; adenosine triphosphate; ATPase; ATP synthase; [Ca2+]i; intracellular calcium concentration; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; CICR; calcium-induced calcium release; DAG; di

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Functional importance of GLP-1 receptor species and expression levels in cell lines

Keywords: Incretin; Liraglutide; GPCR; Metabolite;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Voltage sensitivities and deactivation kinetics of histamine H3 and H4 receptors

Keywords: GIRK; G-protein coupled inward rectifier potassium channel; GPCR; G protein-coupled receptor; H3445; human histamine H3445 receptor; H3365; human histamine H3365 receptor; hH4; human histamine H4 receptor; mH4; murine histamine H4 receptor; RAMH; (R)-α-m

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Topogenesis of heterologously expressed fragments of the human Y4 GPCR

Keywords: GPCR; Membrane protein folding; Y-receptor; Topology screening; GFP; PhoA;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Insight into pattern of codon biasness and nucleotide base usage in serotonin receptor gene family from different mammalian species

Keywords: 5-HT; 5-Hydroxy tryptamine; GPCR; G-Protein Coupled Receptor; 7-TM; 7-Transmembrane; CDS; Coding Sequences; RSCU; Relative Synonymous Codon Usage; COA; Correspondance Analysis; SD; Standard Deviation; ENc; Effective Number of Codons; GES; Goldman Engelman

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

The anterograde transport of the human neuropeptide Y2 receptor is regulated by a subtype specific mechanism mediated by the C-terminus

Keywords: Anterograde transport; Neuropeptide Y receptor; C-terminus; Protein trafficking; Subtype specific difference; aa; amino acids; ER; endoplasmic reticulum; GPCR; G protein-coupled receptor; YR; neuropeptide Y receptor; hY1R; human neuropeptide Y1 receptor;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes

Keywords: α1-AR; alpha1-adrenergic receptor; α1A-WT; wild-type alpha1-adrenergic receptor A subtype; α1AKO; alpha1-adrenergic receptor A subtype single knockout; α1B-WT; wild-type alpha1-adrenergic receptor B subtype; α1BKO; alpha1-adrenergic receptor B subtyp

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Surface masking shapes the traffic of the neuropeptide Y Y2 receptor

Keywords: AcLeu; human neuropeptide Y(24-36) acetyl-Leu(28 31); BIBP326; R-N 2-(diphenylacetyl)-N-(4-hydroxyphenyl)methyl-arginineamide; BIIE0246; N-[(1S)-4-[(aminoiminomethyl)amino]-1-[([2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino)carbonyl]butyl

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Functional interactions between the oxytocin receptor and the β2-adrenergic receptor: Implications for ERK1/2 activation in human myometrial cells

Keywords: AC; adenylyl cyclase; β2AR; β2-adrenergic receptor; cAMP; cyclic adenosine monophosphate; CFP; cyanide fluorescent protein; CYP; cyanopindolol; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethylsulphoxide; DNA; deoxyribonucleic acid; EGF; epitheli

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Allosteric interactions within the AT1 angiotensin receptor homodimer: Role of the conserved DRY motif

Keywords: GPCR; Dimerization; Angiotensin receptor; Allosteric interaction; BRET

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo

Keywords: CB1 cannabinoid receptor; Agonist-selective coupling; Tyrosine hydroxylase; GPCR; G protein; DopamineCP 55,940, (1R,3R,4R)-3-[2-hydroxy-4-(1,1-dimethylheptyl) phenyl]-4-(3-hydroxypropyl)cyclohexan-1-ol; DMSO, dimethylsulfoxide; DOPAC, 3,4-dihydroxyphenyla

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Protease-activated receptor 1 (PAR1) coupling to Gq/11 but not to Gi/o or G12/13 is mediated by discrete amino acids within the receptor second intracellular loop

Keywords: BBB; blood-brain barrier; BSA; bovine serum albumin; DMEM; Dulbecco's modified Eagle's medium; ECL; enhanced chemiluminescence; ERK; extracellular signal-regulated kinase; GPCR; G protein-coupled receptor; GRK2; G protein-coupled receptor kinase-2; InsP

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

cAMP: Novel concepts in compartmentalised signalling

Keywords: cAMP; cyclic adenosine 3′,5′-monophosphate; GPCR; G protein-coupled receptor; EC coupling; excitation-contraction coupling; FRET; Förster/fluorescence resonance energy transfer; CFP; cyan fluorescent protein; YFP; yellow fluorescent protein; AKAR;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

D2-like dopamine and β-adrenergic receptors form a signaling complex that integrates Gs- and Gi-mediated regulation of adenylyl cyclase

Keywords: AC; adenylyl cyclase; βAR and β2AR; β-adrenergic and β2-adrenergic receptor(s), respectively; BRET; bioluminescence resonance energy transfer; D2DR; D3DR and D4DR, D2-, D3-, and D4-dopamine receptor(s), respectively; EGFP; enhanced green fluorescent p

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Endocytosis and post-endocytic sorting of connexins

Keywords: CHO; Chinese hamster ovary; CIP75; connexin43-interacting protein of 75-kDa; CIP85; connexin43-interacting protein of 85-kDa; Dab2; disabled-2; EEA1; early endosomal autoantigen 1; EGF; epidermal growth factor; ENaC; amiloride-sensitive epithelial sodium

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. Synthesis and structure-relationships of α,α-tetrahydropyranylglycine

Keywords: Bradykinin; B2 antagonist; Inflammation; GPCR; Residence time;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Differences in neuropeptide Y-induced secretion of endothelin-1 in left and right human endocardial endothelial cells

Keywords: Neuropeptide Y; NPY receptors; Endocardial endothelial cells; Endothelin-1; ET-1 secretion; GPCR; Human endothelium; Excitation-secretion coupling; NPY receptor antagonist; Y5 receptor;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Autocrine CCL2 promotes cell migration and invasion via PKC activation and tyrosine phosphorylation of paxillin in bladder cancer cells

Keywords: CTC; chelerythrine chloride; GPCR; G protein-coupled receptor; MCP-1; monocyte chemoattractant protein-1; pPaxillin; tyrosine 118 phosphorylated paxillin; PKC; protein kinase C; PMA; phorbol 12-myristate 13-acetate; RS; RS-102895; shRNA; short hairpin RNA

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Diacylglycerol kinase ζ: At the crossroads of lipid signaling and protein complex organization

Keywords: APC; antigen-presenting cell; DAG; diacylglycerol; DGK; diacylglycerol kinase; GFP; green fluorescent protein; GPCR; G protein-coupled receptor; LTP; long-term potentiation; MARCKS; myristoylated alanine-rich C kinase substrate protein; PDZ-bm; PDZ bindin

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Calcitonin-like diuretic hormones in insects

Keywords: Neuropeptide; Neurohormone; Diuretic hormone 31 (DH31); GPCR; Malpighian tubules; Diuresis; Visceral muscle; Excretory system;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Synthetic biology with surgical precision: Targeted reengineering of signaling proteins

Keywords: Cell signaling; Signaling pathways; Arrestin; GPCR; Scaffold protein; Protein engineering; Cell survival; Cell death

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Receptor-independent cellular uptake of pituitary adenylate cyclase-activating polypeptide

Keywords: ATP, adenosine triphosphate; BOP, benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate; CPP, cell-penetrating peptide; cAMP, cyclic adenosine mono-phosphate; dNTP, deoxynucleotide triphosphate; FITC, Fluorescein isothiocyanate; GPCR

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Melanocortin 5 receptor signaling and internalization: Role of MAPK/ERK pathway and β-arrestins 1/2

Keywords: CREB; cAMP-responsive element binding protein; ERK; extracellular-regulated protein kinase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GFP; green fluorescent protein; GPCR; G-protein coupled receptor; HRP; horseradish peroxidase; MC5R; melanocortin

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

β-Arrestin2 Regulates Cannabinoid CB1 Receptor Signaling and Adaptation in a Central Nervous System Region–Dependent Manner

Keywords: Beta-arrestin; cannabinoid receptors; GPCR; statistical parametric mapping; tolerance

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

High-throughput screening with a miniaturized radioligand competition assay identifies new modulators of human α2-adrenoceptors

Keywords: α2-Adrenoceptors; Lysergol; 2″,2‴′-Bisepigallocatechin digallate2″,2‴′-Bisepigallocatechin digallate; Partial agonist; GPCR; Chemical libraries

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Activation and molecular recognition of the GPCR rhodopsin – Insights from time-resolved fluorescence depolarisation and single molecule experiments

Keywords: GPCR; Visual phototransduction; Rhodopsin; GPCR helix 8; Protein dynamics; Time-resolved fluorescence depolarisation; Fluorescence anisotropy; Surface potential; Single particle tracking

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners

Keywords: AMPK; AMP-activated protein kinase; ARF; ADP-ribosylation factor; CDK5; cyclin-dependent kinase 5; CEM; caveolin-enriched membrane; CRMP-2; collapsin response mediator protein-2; EGF; epidermal growth factor; EGFR; EGF receptor; GAP; GTPase-activating pro

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

'PUFA-GPR40-CREB signaling' hypothesis for the adult primate neurogenesis

Keywords: AC; adenylyl cyclase; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ARA; arachidonic acid; BDNF; brain-derived neurotrophic factor; BrdU; bromodeoxyuridine; [Ca2+]i; intracellular Ca2+ concentration; CaMK; calmodulin-dependent kinase; cAMP;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Functional characterization of transmembrane adenylyl cyclases from the honeybee brain

Keywords: Behavior; Cellular signaling; GPCR; Learning and memory; Second messenger; cAMP; Adenosine 3′, 5′-cyclic monophosphate; CNG; cyclic nucleotide-gated; Flp-In-293; human embryonic kidney cell line; G 418; gentamycin sulfate; G protein; GTP-binding prote

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Molecular simulations and solid-state NMR investigate dynamical structure in rhodopsin activation

Keywords: CHARMM; Chemistry at Harvard Macromolecular Mechanics; EPR; electron paramagnetic resonance; FTIR; Fourier transform infrared; GPCR; G protein-coupled receptor; MD; molecular dynamics; Meta I; metarhodopsin I; Meta II; metarhodopsin II; 2MBD; 2-methyl-but

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه