دانلود مقالات ISI درباره Gpcr + ترجمه فارسی

Imaging S1P1 activation in vivo

Keywords: S1P1; sphingosine-1-phosphate receptor 1; S1P; sphingosine-1-phosphate; GPCR; G protein-coupled receptor; ApoM; apolipoprotein M; HDL; high-density lipoprotein; HEV; high endothelial venules; MS; multiple sclerosis; tTA; tetracycline transcriptional activ

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Lateral diffusion contributes to FRET from lanthanide-tagged membrane proteins

Keywords: GPI-anchored proteins; FRET; GPCR; Diffusion; HTRF; TR-FRET;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Lysophosphatidylethanolamine increases intracellular Ca2+ through LPA1 in PC-12 neuronal cells

Keywords: Lysophosphatidylethanolamine; LPA1; Lysophosphatidic acid; GPCR; Neuron; Receptor;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2

Keywords: GPR64; GPCR; G protein; Molecular pharmacology; Signal transduction; Peptide agonist; 7TM; seven-transmembrane spanning domain; CTF; C-terminal fragment; ECD; extracellular domain; eV; empty vector; DMEM; dulbecco minimum essential medium; ELISA; enzyme-l

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Frizzleds and WNT/β-catenin signaling - The black box of ligand-receptor selectivity, complex stoichiometry and activation kinetics

Keywords: Receptor complex; Canonical signaling; GPCR; LRP5/6; Class Frizzled;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Phytophthora sojae and soybean isoflavones, a model to study zoospore chemotaxis

Keywords: Phytophthora sojae; Zoospores; Chemotaxis; Isoflavones; G-protein; GPCR

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Biochemical characterization of a heterotrimeric Gi-protein activator peptide designed from the junction between the intracellular third loop and sixth transmembrane helix in the m4 muscarinic acetylcholine receptor

Keywords: Muscarinic acetylcholine receptor; GPCR; Mimetic peptide; Gαi1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Complex formation and functional interaction between adenosine A1 receptor and type-1 metabotropic glutamate receptor

Keywords: Adenosine receptor; Metabotropic glutamate receptor; FRET; GPCR; cAMP

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases

Keywords: Breast cancer; GPCR; AGTR1; ACE; Metastases;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M1 agonists

Keywords: KOQVBYSCBCRVQJ-SVUXJTORSA-N; GPCR; G protein-coupled receptors; CHO; Chinese hamster ovary; GTPγ35S; [35S]-guanosine-5′-O-(3-thio)triphosphate; BOC; butoxycarbony; EC50; half maximal effective concentration of drug; pKa; log of acid dissociation consta

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat

Keywords: Prostacyclin; IP receptor agonist; GPCR; PAH;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Sphingolipids in the function of G protein-coupled receptors

Keywords: 5-HT1A receptors; serotonin1A receptors; 8-OH-DPAT; 8-hydroxy-2(di-N-propylamino)tetralin; CCK receptor; cholecystokinin receptor; ER; endoplasmic reticulum; FB1; fumonisin B1; GM1; monosialotetrahexosylganglioside; GPCR; G protein-coupled receptor; GQ1b;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor

Keywords: DOI; 2,5-Dimethoxy-4-iodoamphetamine; GPCR; G protein-coupled receptor; NaBu; sodiumbutyrate; NMDG; N-methyl-D-glucamine; Atypical antipsychotics; Clozapine; Dissociation kinetics; Intrinsic activity; Residence time; Schizophrenia;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Structure versus function—The impact of computational methods on the discovery of specific GPCR–ligands

Keywords: G-protein coupled receptors; Molecular modeling; In silico tools; Computational drug design; Docking; Molecular dynamics; 3D pharmacophore modeling; GPCR

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Ligand-induced internalization, recycling, and resensitization of adrenomedullin receptors depend not on CLR or RAMP alone but on the receptor complex as a whole

Keywords: Adrenomedullin; CGRP; CLR; RAMP; GPCR; Signaling

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2

Keywords: 5-HT; 5-hydroxytryptamine; cAMP; 3′,5′-cyclic adenosine monophosphate; ERK1/2; extracellular signal-regulated kinases 1/2; GPCR; G protein-coupled receptor; LogEC50; logarithm of agonist concentration that induces half-maximal response; Emax; maximal

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

The A- and B-type muscarinic acetylcholine receptors from Drosophila melanogaster couple to different second messenger pathways

Keywords: G protein-coupled receptor; GPCR; Acetylcholine; Hormone; Signaling; Insect;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Extracellular acidification activates ovarian cancer G-protein-coupled receptor 1 and GPR4 homologs of zebra fish

Keywords: Zebra fish; OGR1; GPR4; Proton sensing; 1z; zebra fish (Danio rerio); OGR1; ovarian cancer G-protein-coupled receptor 1; GPCR; G-protein-coupled receptor;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

The Origin, Expression, Function and Future Research Focus of a G Protein-coupled Receptor, Mas-related Gene X2 (MrgX2)

Keywords: Mas-related gene X2 (MrgX2); dorsal root ganglion (DRG); mast cell; nociception; immunity.; Mrgs; Mas-related genes; MRG; protein peptides of Mas-related genes; MrgX2; gene of Mas-related G protein-coupled receptor member X2; MRGX2; protein peptides of Ma

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Functional characterization of five different PRXamide receptors of the red flour beetle Tribolium castaneum with peptidomimetics and identification of agonists and antagonists

Keywords: GPCR; Pyrokinin; CAPA; PBAN; ETH; pharmacology;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Pharmacological characterization of a tyramine receptor from the southern cattle tick, Rhipicephalus (Boophilus) microplus

Keywords: Tyramine receptor; Southern cattle tick; G-protein-coupled receptor; GPCR; Tick; Rhipicephalus microplus;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Quantitative measurement of cell membrane receptor internalization by the nanoluciferase reporter: Using the G protein-coupled receptor RXFP3 as a model

Keywords: Receptor; Internalization; Bioluminescence; Relaxin-3; RXFP3; GPCR;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Uptake of the butyrate receptors, GPR41 and GPR43, in lipidic bicontinuous cubic phases suitable for in meso crystallization

Keywords: SAXS; small angle X-ray scattering; GPCRs; G-protein coupled receptors; PT; phytantriol; MO; monoolein; LP; lattice parameter; In meso crystallization; Bicontinuous cubic phase; GPCR; Butyrate receptor; GPR41; GPR43; Monoolein; Phytantriol;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Very high resolution single pass HLA genotyping using amplicon sequencing on the 454 next generation DNA sequencers: Comparison with Sanger sequencing

Keywords: gPCR; genomic PCR; CWD; common and well-documented; HLA; human leukocyte antigen; HSCT; hematopoietic stem cell transplantation; HR; high resolution; MID; multiplex identifier; MM; mismatches; NGS; next generation sequencing; PTP; PicoTiter Plate; RMS; Ro

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Translating Basic Research Into Clinical PracticeProstanoids in Asthma and COPD: Actions, Dysregulation, and Therapeutic Opportunities

Keywords: cAMP; cyclic adenosine monophosphate; COX; cyclooxygenase; EP; E prostanoid receptor; Epac; exchange protein activated by cyclic adenosine monophosphate; GPCR; G protein-coupled receptor; IP; I prostanoid receptor; PG; prostaglandin; PKA; protein kinase A

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Short communicationIdentification, expression and immunological responses to bacterial challenge following vaccination of BLT1 gene from turbot, Scophthalmus maximus

Keywords: LTB4; leukotriene B4; BLT1; leukotriene B4 receptor; BLT2; leukotriene B4 receptor 2; TM; transmembrane; GPCR; G-protein-coupled receptor; VHSV; viral hemorrhagic septicemia virus; ORF; open reading frame; RACE; rapid-amplification of cDNA ends; ICL; intr

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Misfolded opsin mutants display elevated β-sheet structure

Keywords: CD; circular dichroism; CFP; cyan fluorescent protein; DM; n-dodecyl-β-d-maltoside; ER; endoplasmic reticulum; FRET; Förster resonance energy transfer; FTIR; Fourier transform infrared; GPCR; G protein-coupled receptor; MII; metarhodopsin II; mRho; muri

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Biosensor-based affinities and binding kinetics of small molecule antagonists to the adenosine A2A receptor reconstituted in HDL like particles

Keywords: DDM; n-dodecyl-β-d-maltoside; DM; decyl-β-d-maltopyranoside; GPCR; G protein-coupled receptor; NTA; nitrilotriacetic acid; PhT; phenol triazine; POPC; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; POPG; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglyce

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling

Keywords: Aripiprazole; Dopamine; Gbetagamma; GPCR; Functional selectivityAripiprazole (PubChem CID: 60795); dopamine hydrochloride (PubChem CID: 65340); pramipexole dihydrochloride (PubChem CID: 166589); ropinirole hydrochloride (PubChem CID: 68727); rotigotine hy

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain

Keywords: GPCR; G-protein-coupled receptor; Hx8; Helix-8; TM7; seven transmembrane; GPCR signaling; GPCR-PDZ interaction; Biased molecular dynamics; Steered molecular dynamics simulation; Palmitoylation and depalmitoylation; Membrane insertion GPCR-membrane int

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Role of lipid microdomains in TLR-mediated signalling

Keywords: ABCA1/G1; ATP-binding cassette, sub-family A/G, member 1; AP-1; activator protein 1; CARC; inverted “CRAC” domain; CD 14/36/55; cluster of differentiation 14/36/55; CRAC; cholesterol recognition amino-acid consensus sequence; CXCR4; C-X-C chemokine re

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism

Keywords: GPCR; G protein-coupled receptor; OX1R; orexin 1 receptor; KOR; kappa opioid receptor; JNK; c-Jun N-terminal kinase; cAMP; cyclic adenosine monophosphate; VTA; ventral tegmental area; CHO; Chinese hamster ovary; FLIPR; fluorescence in situ plate reader; P

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

The roles of ribosomal protein S19 C-terminus in a shortened neutrophil lifespan through delta lactoferrin

Keywords: C5aR; C5a receptor; δLf; delta lactoferrin; GPCR; G protein-coupled receptor; NY-1; anti-RP S19 rabbit IgGs; PMX-53; C5aR antagonistic peptide; RGS3; regulator of G protein signaling 3; RP S19; ribosomal protein S19; sLf; secreted form of Lactoferrin; TR

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

The GPCR heterotetramer: challenging classical pharmacology

Keywords: GPCR; oligomerization; signalosome; adenylyl cyclase

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

A single mutation in helix 8 enhances the angiotensin II type 1a receptor transport and signaling

Keywords: GPCR; G protein-coupled receptor; Ang II; angiotensin II; AT1R; angiontensin II type 1 receptor; AT1aR; angiontensin II type 1a receptor; AT2R; angiontensin II type 2 receptor; MAPK; mitogen-activated protein kinase; ERK1/2; extracellular signal-regulated

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Development of a CCK1R-membrane nanoparticle as a fish-out tool for bioactive peptides

Keywords: Cholecystokinin receptor type 1; Cholecystokinin; NABBs; GPCR; Affinity-selection;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Lipid agonism: The PIP2 paradigm of ligand-gated ion channels

Keywords: AA; arachidonic acid; ASIC; acid-sensing ion channel; ATP; adenosine triphosphate; BK; big conductance potassium channel; Cav; voltage-dependent calcium channel or VDCC; Ci-VSP; Ciona intestinalis voltage-sensitive phosphatase; CoA; coenzyme A; CTD; cytop

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Research ReportInvolvement of NFκB signaling in mediating the effects of GRK5 on neural stem cells

Keywords: AD; Alzheimer׳s disease; GPCR; G protein-coupled receptor; GRK; G-protein receptor kinase; IL-6; interleukin-6; IL-1β; interleukin-1β; NAC; N-acetyl cysteine; NFκB; nuclear factor κB; NPCs; neural progenitor cells; NSCs; neuron stem cells; PKA; prote

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Helix 3 acts as a conformational hinge in Class A GPCR activation: An analysis of interhelical interaction energies in crystal structures

Keywords: GPCR; G protein-coupled receptor; TM; transmembrane; TMH; transmembrane helix; Cα-DAI; difference between the distances between a Cα atom in one helix and the nearest Cα in a second helix in active and inactive states; LJ; Lennard-Jones; RHO; rhodops

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Pharmacological lineage analysis revealed the binding affinity of broad-spectrum substance P antagonists to receptors for gonadotropin-releasing peptide

Keywords: AVP; arginine-vasopressin; ERK; extracellular signal-regulated kinase; GPCR; G-protein-coupled receptor; [Ca2+]i; intracellular Ca2+ concentration; OT; oxytocin; Substance P (6-11), Arg(6)-Trp(7,9)-Me-Phe(8)- (PubChem CID: 131091); Substance P, Phe(5)-Trp

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Structural mechanism of G protein activation by G protein-coupled receptor

Keywords: GPCR; G protein; Structure;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Gαi/o-dependent Ca2+ mobilization and Gαq-dependent PKCα regulation of Ca2+-sensing receptor-mediated responses in N18TG2 neuroblastoma cells

Keywords: N18TG2 cells; Neuronal CaS; Gαq antisense knock-down; Gαi/o; Ca2+ mobilization; CaS responses; Protein kinase C; AEA; anandamide; 2-APB; 2-aminoethyldiphenyl borate; DRG; dorsal root ganglion; EGFP; enhanced green fluorescent protein; GPCR; G protein-co

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Melanocortin 4 receptor activates ERK-cFos pathway to increase brain-derived neurotrophic factor expression in rat astrocytes and hypothalamus

Keywords: α-MSH; α-melanocyte-stimulating hormone; AC; adenylate cyclase; BDNF; brain-derived neurotrophic factor; CREB; cAMP responsive element binding protein; DAPI; 4′,6-diamido-2-phenylindole dihydrochloride; ERK; extracellular signal-regulated kinase; GFAP

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Selectivity of commonly used inhibitors of clathrin-mediated and caveolae-dependent endocytosis of G protein-coupled receptors

Keywords: Endocytosis; Clathrin; Caveolae; GPCR; RNA interference;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom

Keywords: ASIC; acid-sensing ion channel; CNF; conorfamide; C-terminus; carboxyl terminus; [Ca2 +]i; cytosolic calcium ion concentration; DRG; dorsal root ganglion; FaNaC; FMRF-amide-gated Na+ channel; GPCR; G-protein-coupled receptor; IC; intracranial; MeCN; acet

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines

Keywords: cAMP; cyclic adenosine 5′-monophosphate; CB2; Cannabinoid receptor 2; CI; Cell Index; Δ CI; Δ Cell Index or Delta Cell Index; DMSO; dimethylsulfoxide; EBV; Epstein-Barr Virus; EC50; half maximal effective concentration; EC80; 80% maximal effective c

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

New insights into the model of dopamine D1 receptor and G-proteins interactions

Keywords: FRAP; FLIM-FRET; G-protein; GPCR; Dopamine receptor; G-protein coupling;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Role of cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) in regulating the trafficking and signaling of corticotropin-releasing factor receptor 1

Keywords: 5HT2AR; Serotonin 2A receptor; ACTH; Adrenocorticotropin hormone; ANOVA; Analysis of variance; CAL; CFTR-associated ligand; cAMP; Cyclic adenosine monophosphate; CFTR; Cystic Fibrosis Transmembrane Conductance Regulator; CNS; Central nervous system; CRF;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of amino acids that are selectively involved in Gi/o activation by rat melanin-concentrating hormone receptor 1

Keywords: cAMP; cyclic AMP; DMR; dynamic mass redistribution; GPCR; G-protein-coupled receptor; GTPγS; guanosine 5′-O-[gamma-thio]triphosphate; i1; first intracellular; i2; second intracellular; i3; third intracellular; MCH; melanin-concentrating hormone; MCHR;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Fluoro-substituted phenylazocarboxamides: Dopaminergic behavior and N-arylating properties for irreversible binding

Keywords: Covalent ligands; Bioisosteres; Azocarboxamide; Dopamine; D3 receptor; GPCR

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه