
pVHL interacts with Ceramide kinase like (CERKL) protein and ubiquitinates it for oxygen dependent proteasomal degradation
Keywords: pVHL; the Von Hippel-Lindau tumor suppressor protein; ECV complex; elongin B/C-Cul2-VHL protein complex; PHD1-3; prolyl hydroxylase domain proteins 1-3; UPS; ubiquitin proteasome system; HIFs; hypoxia inducible factors; ROS; reactive oxygen species;