Role of Akt/HO-1 pathway in estrogen-mediated attenuation of trauma-hemorrhage-induced lung injury
Keywords: Hemorrhagic shock; Estrogen; Akt; HO-1; Lung injury
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The natural product honokiol inhibits calcineurin inhibitor-induced and Ras-mediated tumor promoting pathways
Keywords: Honokiol; Ras; VEGF; HO-1; Renal tumor
Interaction of inflammatory and anti-inflammatory responses in microglia by Staphylococcus aureus-derived lipoteichoic acid
Keywords: Lipoteichoic acid; Microglia; Inflammation; Anti-inflammation; HO-1
Exendin-4 ameliorates renal ischemia-reperfusion injury in the rat
Keywords: Renal ischemia-reperfusion; Glucagon-like peptide-1; Exendin-4; Male rats; Heme oxygenase-1; HO-1; Apoptosis; Caspase-3; Macrophage
Genistein Inhibits ox-LDL-induced VCAM-1, ICAM-1 and MCP-1 Expression of HUVECs Through Heme Oxygenase-1
Keywords: Genistein; Atherosclerosis; Inflammation; HO-1; Nrf2
Heme oxygenase-1 regulates postnatal lung repair after hyperoxia: Role of β-catenin/hnRNPK signaling
Keywords: HO-1; heme oxygenase-1; KO; knockout; MEF; mouse embryonic fibroblasts; RAC; radial alveolar counts; O2/air; exposed to 95% oxygen for 3 days then recovered in air; hnRNPK; heterogeneous nuclear ribonucleoprotein protein K; SP-B; surfactant protein B; SP-
Acanthopanax senticosus exerts neuroprotective effects through HO-1 signaling in hippocampal and microglial cells
Keywords: Acanthopanax senticosus; CREB; Nrf2; HO-1; Neuroprotection
Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; COX-2; cyclooxygenase-2; DAPI; 4,6-diamidino-2-phenylindole; DET; deoxyelephantopin; FHF; fulminant hepatic failure; D-GalN; d-galactosamine; HO-1; heme oxygenase-1; IL-6; interleukin-6; iNOS
Heme oxygenase-1 (HO-1) is constitutively up-regulated in top alpinists
Keywords: Hypoxia; Mt. Everest; HO-1; CO; Microarray
Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia
Keywords: ARE; antioxidant-response element; CA; carnosic acid; DMSO; dimethyl sulfoxide; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; gclc; glutamate-cysteine ligase, catalytic subunit; gclm; glutamyl cysteine ligase modifier subunit; HO-
Smad7 sensitizes A549 lung cancer cells to cisplatin-induced apoptosis through heme oxygenase-1 inhibition
Keywords: Smad7; HO-1; Apoptosis; Akt; A549 cells;
Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity
Keywords: ARE; antioxidant response element; HO-1; heme oxygenase-1; Keap1; kelch-like ECH-associated protein 1; NQO1; NAD(P)H quinone oxidoreductase-1; Nrf2; nuclear factor E2-related factor 2; ROS; reactive oxygen species; Eriodictyol-7-O-glucoside; Nrf2; Activat
Diallyl-disulphide is the effective ingredient of garlic oil that protects primary human osteoblasts from damage due to cigarette smoke
Keywords: Cigarette smoke; Osteoblasts; Oxidative stress; Garlic; CSM; cigarette smoke medium; DADS; diallyl-disulphide; DAS; diallyl-sulphide; DPBS; Dulbecco's phosphate buffered saline; GOB; garlic oil blend; HO-1; haeme-oxygenase 1; ROS; reactive oxygen specie
Down-regulation of heme oxygenase-1 by SVCV infection
Keywords: SVCV; HO-1; Common carp; Heat-shock protein 32; Oxidative stress
Healing the diabetic heart: Does myocardial preconditioning work?
Keywords: I/R; Ischemia-reperfusion; TNF-α; Tumor necrosis factor-alpha; IPC; Ischemic preconditioning; FWOP; First window of protection; SWOP; Second window of protection; TWOP; Third window of protection; eNOS; Endothelial nitric oxide synthase; NO; Nitric oxi
The effect of oxidized low density lipoprotein (oxLDL)-induced heme oxygenase-1 on LPS-induced inflammation in RAW 264.7 macrophage cells
Keywords: oxLDL; HO-1; NF-κB; Inflammation; LPS;
Effects of estrogen on endothelial prostanoid production and cyclooxygenase-2 and heme oxygenase-1 expression
Keywords: ARE; AU-rich elements; COX-2; cyclooxygenase-2; eNOS; endothelial NO synthase; E2; 17β-estradiol; ER; estrogen receptor; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HO-1; heme oxygenase-1; HuR; Hu-antigen R; hPGT; human prostaglandin transporter; HU
Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone attenuates postincisional pain by regulating macrophage polarization
Keywords: Arg1; arginase-1; HO-1; heme oxygenase-1; IL; interleukin; ItgaX; integrin αX; MIP2α; macrophage inflammatory protein 2α; NF-κB; nuclear factor κB; PPARγ; peroxisome proliferators-activated receptor γ; PPARγ; Rosiglitazone; Macrophage polarity; Po
Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation
Keywords: Nrf2; NF-E2-related factor 2; BM; bone marrow; BMT; bone marrow transplantation; LDL; low density lipoprotein; CM; chylomicron; HDL; high-density lipoprotein; TG; triglyceride; CHO; cholesterol; VCAM-1; vascular cell adhesion molecule 1; ICAM-1; intercell
Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage
Keywords: ALD; alcoholic liver disease; ARE; antioxidant response element; AST; aspartate transaminase; CAT; catalase; GSH; glutathione; CYP 2E1; cytochrome P450 2E1; ERK; extracellular signal-regulated kinase; HO-1; heme oxygenase-1; JNK; c-Jun N-terminal kinase;
Curcumin-induced heme oxygenase-1 expression plays a negative role for its anti-cancer effect in bladder cancers
Keywords: DCF; dichlorofluorescin; FBS; fetal bovine serum; HBSS; hanks' balanced salt solution; HO-1; heme oxygenase-1; MMP-2/9; matrix metalloproteinase-2/9; MTT; 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide; NF-κB; nuclear factor-kappaB; ROS; r
Research ReportHeme oxygenase-1 regulates the JNK signaling pathway through the MLK3-MKK7-JNK3 signaling module in brain ischemia injury
Keywords: HO-1; Heme oxygenase-1; JNK3; c-Jun N-terminal kinase 3; MLK3; mixed lineage kinase 3; MKK7; mitogen-activated kinase kinase 7; I/R; ischemia/reperfusion; SD; Sprague-Dawley; HO-1; JNK3; Brain ischemia; Reperfusion;
Guanosine protects human neuroblastoma SH-SY5Y cells against mitochondrial oxidative stress by inducing heme oxigenase-1 via PI3K/Akt/GSK-3β pathway
Keywords: BK; large (big) conductance Ca2+-activated K+ channels; DPCPX; 1,3-dipropyl-8-cyclopentylxanthine; GUO; guanosine; GSK-3β; glycogen synthase kinase 3β; H2DCFDA; 2â²,7â²-dichlorofluorescein diacetate; HO-1; heme oxygenase-1; LY294002; 2-(4-morpholinyl)
Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance
Keywords: ARE; antioxidant-response element; CLS; crownlike structure; HFD; high-fat diet; HO-1; heme oxygenase-1; KO; knockout; Nrf2; NF-E2-related factor 2; OxPAPC; oxidized 1-palmitoyl-2-arachidonoyl-sn-3-glycerophosphorylcholine; Srxn1; sulfiredoxin-1; IL; inte
Shock/Sepsis/Trauma/Critical CareHemin induction of HO-1 protects against LPS-induced septic ileus
Keywords: HO-1; Hemin; iNOS; Intestinal contractility; Septic ileus;
Delphinidin-3-O-galactoside protects mouse hepatocytes from (â)-epigallocatechin-3-gallate-induced cytotoxicity via up-regulation of heme oxygenase-1 and heat shock protein 70
Keywords: CHOP; C/EBP-homologus protein; Cu/ZnSOD; copper/zinc superoxide dismutase; D3G; delphinidin-3-O-galactoside; EGCG; (â)-epigallocatechin-3-gallate; ER stress; endoplasmic reticulum stress; HO-1; heme oxygenase-1; HSP70; heat shock protein 70; MnSOD; mang
Maslinic acid induces HO-1 and NOQ1 expression via activation of Nrf2 transcription factor
Keywords: Maslinic acid; HO-1; NQO1; Nrf2COX, Cyclooxygenase; BNF-κ, BNuclear factor-kappa; AP-1, Activator protein-1; IL, Interleukins; TNF, Tumour necrosis factor; iNOS, Inducible nitric oxide synthase; HO-1, Heme-oxygenase-1; NQO1, NAD(P)H: quinone oxidoreductas
The protection by Octreotide against experimental ischemic stroke: Up-regulated transcription factor Nrf2, HO-1 and down-regulated NF-κB expression
Keywords: Octreotide; Protection; Ischemic stroke; Nrf2; HO-1; NF-κB
Impaired response of hypoxic sensor protein HIF-1α and its downstream proteins in the spinal motor neurons of ALS model mice
Keywords: ALS; HIF-1α; VEGF; HO-1; EPO
Evaluation of Cissus quadrangularis extracts as an inhibitor of COX, 5-LOX, and proinflammatory mediators
Keywords: Cissus quadrangularis; Cycloxygenase; Inflammation; COX-1; COX-2; 5-LOX; COX-LOX inhibition; AA; Proinflammatory mediator; Nrf-2; HO-1;
Extract of Salvia miltiorrhiza (Danshen) induces Nrf2-mediated heme oxygenase-1 expression as a cytoprotective action in RAW 264.7 macrophages
Keywords: Salvia miltiorrhiza (Danshen); HO-1; Nrf2; Macrophages; Oxidative stress;
Hydrogen sulfide modulates the release of nitric oxide and VEGF in human keratinocytes
Keywords: ANOVA; analysis of variance; CO; carbon monoxide; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; HO-1; heme oxygenase-1; GSNO; S-Nitroso-l-glutathione; GYY4137; morpholin-4-ium-4-methoxyphenyl(morpholino) phosphinodithioate; H2S; hyd
Cardiovascular effects and molecular targets of resveratrol
Keywords: 4-HNE; 4-hydroxy-2-nonenal; ADMA; asymmetric dimethylarginine; AMPK; AMP-activated protein kinase; ApoE; apolipoprotein E; ARE; antioxidant response element; BH4; tetrahydrobiopterin; Cav-1; caveolin-1; COX-1; cyclooxygenase 1; CREB; cAMP response element
p38MAPK and ERK1/2 dictate cell death/survival response to different pro-oxidant stimuli via p53 and Nrf2 in neuroblastoma cells SH-SY5Y
Keywords: AMS; 4-acetamido-4-maleimidylstilbene-2,2-disulfonic acid; ARE; antioxidant response elements; BSO; buthionine sulfoximine; DMSO; dimethyl sulfoxide; DMTU; dimethylthiourea; DN Nrf2; dominant negative Nrf2 protein; DNP; 2,4-dinitrophenylhydrazine; ERK1/2;
Ankaflavin, a novel Nrf-2 activator for attenuating allergic airway inflammation
Keywords: AK; ankaflavin; AREs; antioxidant response elements; BALF; bronchoalveolar lavage fluid; CAT; catalase; DMSO; dimethyl sulfoxide; ECL; enhanced chemiluminescent; ESI-MS; electrospray ionization-mass spectrometry; FBS; fetal bovine serum; GABA; γ-aminob
Research ArticleBak deficiency inhibits liver carcinogenesis: A causal link between apoptosis and carcinogenesis
Keywords: HCC; hepatocellular carcinoma; ALT; alanine aminotransferase; RT-PCR; reverse-transcription PCR; HO-1; heme oxygenase-1; NQO1; NAD(P)H:quinone oxidoreductase 1; 8-OHdG; 8-hydroxy-2â²-deoxyguanosine; TUNEL; terminal deoxynucleotidyl transferase-mediated d
Dangkwisoo-san, an herbal medicinal formula, ameliorates acute lung inflammation via activation of Nrf2 and suppression of NF-κB
Keywords: Nrf2; nuclear factor (NF)-erythroid (E) 2 related factor 2; GCL; Cglutamate-cysteine ligase catalytic subunit; NQO1; NAD(P)H:quinine oxidoreductase-1; HO-1; heme oxygenase-1; IKK; inhibitory κB kinase; Acute lung inflammation; Anti-inflammation; Nrf2; NF
Histone deacetylase 6 (HDAC6) plays a crucial role in p38MAPK-dependent induction of heme oxygenase-1 (HO-1) in response to proteasome inhibition
Keywords: DAPI; 4â²,6-diamidino-2-phenylindole; DCF; 2â²,7â²-dichlorofluorescein; DMSO; dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol tetraacetic acid; FCS; fetal calf serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HO-
EET agonist prevents adiposity and vascular dysfunction in rats fed a high fat diet via a decrease in Bach 1 and an increase in HO-1 levels
Keywords: CYP, cytochrome P450; EETs, epoxyeicosatrienoic acids; NUDSA, EET agonist; HO, heme oxygenase; SnMP, stannous mesoporphyrin; ROS, reactive oxygen species; IR, insulin receptor; O2−, superoxide; sEH, soluble epoxide hydrolaseCytochrome P450; HO-1; Metaboli
Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells: therapeutic relevance to neurodegenerative disease
Keywords: HO-1; Licochalcone E; Neuroprotection; NQO1; Nrf2; Parkinson's disease
Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase
Keywords: STK; stem cell-derived tyrosine kinase; IL; interleukin; MCP-1; monocyte chemoattractant protein-1; NAPQI; N-acetyl-p-benzoquinone-imine; Cyp; cytochrome P450; TNFα; tumor necrosis factor-α; TNFR; tumor necrosis factor receptor; HO-1; heme oxygenase-1;
Ginsenoside Rg3 enhances the chemosensitivity of tumors to cisplatin by reducing the basal level of nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1/NAD(P)H quinone oxidoreductase-1 and prevents normal tissue damage by scavenging cisp
Keywords: Ginsenoside Rg3; Cisplatin; ROS scavenging; Nrf2; HO-1; NQO-1;
Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis)
Keywords: ARE; Antioxidant response element; DCF; 2â²,7â²-dichlorofluorescein; DDC; 2â²,3â²-dihydroxy-4â²,6â²-dimethoxychalcone; DHE; Dihydroethidium; DMSO; Dimethyl sulfoxide; EI; Electron impact; ETH; Ethidium; γ-GCS; âγ-glutamylcysteine synthetase; G
Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells
Keywords: ARE; antioxidant response element; CCND1; cyclin D1; CSC; cancer stem cell; E-CAD; E-cadherin; FBS; fetal bovine serum; GCLC; glutamate-cysteine ligase catalytic subunit; GCLM; glutamate-cysteine ligase regulatory subunit; GSN; gelsolin; HO-1; heme ox
Cosupplementation with a synthetic, lipid-soluble polyphenol and vitamin C inhibits oxidative damage and improves vascular function yet does not inhibit acute renal injury in an animal model of rhabdomyolysis
Keywords: AKI; acute kidney injury; β-actin; beta-actin; CCL2/MCP-1; chemokine (C-C motif) ligand 2/monocyte chemotactic protein-1; CCr; creatinine clearance; CE; cholesterylesters derived from linoleic and arachidonic acids; CeO(O)H; cholesterylester hydroperoxid
Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
Keywords: ACC1; acetyl-CoA carboxylase 1; SAMe; S-adenosylmethionine; AMPK; AMP-activated protein kinase; HNE; 4-hydroxy-2-nonenal; ANT; adenine nucleotide translocator; NRTI; antiretroviral nucleoside analog; ChREBP; carbohydrate responsive element-binding protein
Aromatic-turmerone's anti-inflammatory effects in microglial cells are mediated by protein kinase A and heme oxygenase-1 signaling
Keywords: ar-Turmerone; Neuroinflammation; MMP-9; ROS; HO-1; PKA;
Functional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: Possible involvement in neuronal differentiation
Keywords: ATRA; all-trans retinoic acid; CL; cerebellum; CX; cerebral cortex; DIV; days in vitro; DMEM; Dulbecco's modified Eagle's medium; ERGO; ergothioneine; FBS; fetal bovine serum; GAP43; growth-associated protein 43; HC; hippocampus; HO-1; heme oxygenase-
Role of cerebral endothelial cells in the astrocyte swelling and brain edema associated with acute hepatic encephalopathy
Keywords: AA; arachidonic acid; AO; antioxidants; APO; apocynin; AHE; acute hepatic encephalopathy; AQP4; aquaporin-4; CKs; cytokines; CM; conditioned media; CNS; central nervous system; COX2; cyclooxygenase-2; DAPI; 4â², 6-diamidino-2-phenylindole; DHR; dihydrorh
Mechanism of cisplatin resistance in human urothelial carcinoma cells
Keywords: Urothelial carcinoma; Cisplatin; Bcl-2; HO-1; p16;