دانلود مقالات ISI درباره Ic50 + ترجمه فارسی

Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase α

Keywords: Dehydroaltenusin; Enzyme inhibitor; DNA polymerase α; DNA replication; Cytotoxicity; Anti-tumor activity; DMSO; dimethyl sulfoxide; EDTA; ethylenediaminetetracetic acid; IC50; 50% inhibitory concentration; LD50; 50% lethal dose; MTT; 3-(4,5-dimethylthiaz

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Production and characterization of monoclonal antibodies against ochratoxin B

Keywords: ELISA, enzyme-linked immunosorbent assay; HPLC, high performance liquid chromatography; FBS, fetal bovine serum; DMSO, dimethylsulfoxide; PBS, phosphate-balanced saline; PCR, polymerase chain reaction; BSA, bovine serum albumin; IgG, immunglobulin G; IC50

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Preparation and characterization of sericin powder extracted from silk industry wastewater

Keywords: Sericin; Molecular weight; Circular dichroism; Tyrosinase; Radical scavenging activity; IC50

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries

Keywords: Lipoxygenase; High-throughput; NCI; α-mangostin; Michellamine B; Neodysidenin; Dysidenin; Kinetics; IC50

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands

Keywords: CCR5 inhibitor; Viral entry; IC50; Receptor density

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Dynamic Hepatitis C Virus Genotypic and Phenotypic Changes in Patients Treated With the Protease Inhibitor Telaprevir

Keywords: FU; follow-up; IC50; 50% inhibitory concentration; LTFU; long-term follow-up; PCR; polymerase chain reaction; WT; wild-type;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

An ultrasensitive high-throughput electrochemiluminescence immunoassay for the Cdc42-associated protein tyrosine kinase ACK1

Keywords: High-throughput immunoassay; BV-tag; Electrochemiluminescence assay; Cdc42-associated protein tyrosine kinase; ACK1; Ki; IC50; Ultrasensitive

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Enzymatic properties and localization of motopsin (PRSS12), a protease whose absence causes mental retardation

Keywords: APMSF; (4-amidinophenyl) methanesulfonyl fluoride; Boc; t-butyloxycarbonyl; CA; cornu ammonis; CNS; central nervous sytem; DAPI; 4′, 6-diamidino-2-phenylindole; DIV; days in vitro; EDTA; ethylenediaminetetraacetic acid; IC50; 50% inhibitory concentratio

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

Role of water molecules for binding inhibitors in the SH2 domain of Grb2: A molecular dynamics study

Keywords: Grb2 SH2; Molecular dynamics; Solvent effects; Water bridging; Ligand binding; Drug design; EGF-R; epidermal growth factor receptor; Grb2; growth factor receptor bound protein 2; IC50; concentration required for 50% inhibition; MAPK; mitogen-activated pro

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2007 سفارش ترجمه

Structure–activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2

Keywords: Lipoxygenase; Flavonoids; Reductive inhibition; IC50

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2007 سفارش ترجمه

Is subnanomolar binding affinity required for the in vivo imaging of acetylcholinesterase? Studies on 18F-labeled G379

Keywords: Alzheimer's disease; Acetylcholinesterase; G379; 18F; IC50

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2006 سفارش ترجمه

Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice

Keywords: AChE; acetylcholinesterase; 2-AG; 2-arachidonoylglycerol; BDPO; benzodioxaphosphorin oxide; CB1; cannabinoid receptor; CPO; chlorpyrifos oxon; DFP; diisopropyl fluorophosphate; DMSO; dimethyl sulfoxide; EOPF; ethyl octylphosphonofluoridate; FAAH; fatty ac

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases

Keywords: Lipoxygenase; Baicalein; Apigenin; Flavonoids; Kinetics; Reductive inhibition; IC50

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Isolation and characterization of a novel thermostable non-specific lipid transfer protein-like antimicrobial protein from motherwort (Leonurus japonicus Houtt) seeds

Keywords: Motherwort; Antifungal; Antibacterial; nsLTPs; Seeds; IC50

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Vers de nouvelles molécules antibactériennes. Intérêt du para-guanidinoéthylcalix[4]arène

Keywords: Infections Nosocomiales; Calixarènes; Antibactériens; CMI; CI50; Index de SélectivitéNosocomial Infections; Calixarenes; Anti-Bacterial Drugs; MIC; IC50; Selectivity Index

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Effects of ApC, a sea anemone toxin, on sodium currents of mammalian neurons

Keywords: 4-AP; 4-aminopyridine; D50, duration of the action potential measured at 50% of its amplitude; DRG; dorsal-root-ganglion; IC50; half-maximum inhibitory concentration; L15; Leibovitz L15 medium; TEA-Cl; tetraethylamonium chloride; TTX; tetrodotoxin; TTX-S;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Depression of NMDA-receptor-mediated segmental transmission by ketamine and ketoprofen, but not l-NAME, on the in vitro neonatal rat spinal cord preparation

Keywords: AA; arachidonic acid; aCSF; artificial cerebrospinal fluid; CI; confidence intervals; COX; cyclooxygenase; DR-VRP; dorsal root evoked population ventral root potential; EPSP; excitatory postsynaptic potential; IC50; inhibitory concentration at 50% depress

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Design, synthesis, and evaluation of new type of l-amino acids containing pyridine moiety as nitric oxide synthase inhibitor

Keywords: Nitric oxide synthase; Inhibitor; Human; Pyridine; Picoline; Design; Synthesis; IC50; Regioisomer; 2-Aminopyridine; Cysteine; Arginine; Amino acid; Citrulline assay; Computational docking study; Isozyme; Structure–activity relationship; Competitive; Nitri

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

The A/T-specific DNA alkylating agent adozelesin inhibits Plasmodium falciparum growth in vitro and protects mice against Plasmodium chabaudi adami infection

Keywords: aph; aphidicolin; A; adenine; cpm; counts per minute; i.p.; intraperitoneal; iRBC; infected red blood cells; IC50; 50% inhibitory concentration; MAR; matrix attachment regions; p.i.; post-infection; T; thymine; Plasmodium falciparum; Plasmodium chabaudi a

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand

Keywords: 7; 10; 14; 29; IC50; inhibitory concentration of 50%; MTT; (4,5-dimethylthiazo-2-yl)-2,5-diphenyl tetrazolium bromide; TNF; tumor necrosis factor; TRAIL; tumor necrosis factor-related apoptosis-inducing ligand; TUNEL; terminal deoxynucleotidyltransferas

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors

Keywords: Cinnamoyl pyrrolidine derivatives; MMPs inhibitors; IC50;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Water soluble feruloyl arabinoxylans from rice and ragi: Changes upon malting and their consequence on antioxidant activity

Keywords: A:X; arabinose:xylose; AA; antiradical activity; AAC; antioxidant activity coefficient; AC; ammonium carbonate; BHA; butyrated hydroxy anisole; BHT; butyrated hydroxy toluene; BSA; bovine serum albumin; DEAE; diethyl amino ethyl; DPPH*; 1,1-diphenyl-2-pic

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Dopamine D2 receptor-mediated G protein activation assessed by agonist-stimulated [35S]guanosine 5′-O-(γ-thiotriphosphate) binding in rat striatal membranes

Keywords: CHO; Chinese hamster ovary; EC50; the concentration eliciting the half-maximal stimulation; %Emax; the percent maximal increase above the basal binding; G protein; guanine nucleotide-binding regulatory protein; GTPγS; guanosine 5′-O-(γ-thiotriphosphat

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt, in Plasmodium falciparum and Dictyostelium discoideum

Keywords: CQ; chloroquine; CQS; chloroquine sensitivity; CQR; chloroquine resistance; DV; digestive vacuole; h; hour; hdhfr; human dihydrofolate reductase gene; IC50; 50% drug inhibitory concentration value; luc; luciferase gene; min; minutes; PbEF1α; intergenic r

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Targeted Disruption of FANCC and FANCG in Human Cancer Provides a Preclinical Model for Specific Therapeutic Options

Keywords: DEB; diepoxybutane; FA; Fanconi anemia; ICL; DNA interstrand-crosslink; IR; ionizing radiation; KO; knockout; MMC; mitomycin C; PCR; polymerase chain reaction; IC50; the concentration of a drug producing 50% inhibition of growth in vitro; PARP; poly(ADP-r

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Cellular neuroscienceSubtype-dependence of N-methyl-d-aspartate receptor modulation by pregnenolone sulfate

Keywords: glutamate receptor; N-methyl-d-aspartate receptor; neurosteroid; allosteric modulation; open probability; IC50; concentration of pregnenolone sulfate that produces 50% inhibition; EC50; concentration of pregnenolone sulfate that produced 50% potentiation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Molokhia (Corchorus olitorius L.) extract suppresses transformation of the aryl hydrocarbon receptor induced by dioxins

Keywords: AhR; aryl hydrocarbon receptor; Arnt; AhR nuclear translocator; bHLH; basic helix-loop-helix; CYP; cytochrome P450; DMSO; dimethylsulfoxide; DRE; dioxin response element; DTT; dithiothreitol; ELISA; enzyme-linked immunosorbent assay; EROD; ethoxyresol

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro

Keywords: adenosine; sleep; basal forebrain; inwardly rectifying potassium current; hyperpolarization-activated cation current; in vitro slices; ACSF; artificial cerebrospinal fluid; AHP; afterhyperpolarization; cAMP; cyclic AMP; ChAT; choline acetyltransferase; CP

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae

Keywords: GNS; gluconasturtiin; GRA; glucoraphanin; IC50; half-maximal inhibitory concentration; Myr; myrosinase; PARP; poly(ADP-ribose)polymerase; PEITC; β-phenethyl isothiocyanate; Isothiocyanates; Indoles; Apoptosis; Caspases; Colon cancer; Bcl-2 family protein

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Psychrophilic superoxide dismutase from Pseudoalteromonas haloplanktis: biochemical characterization and identification of a highly reactive cysteine residue

Keywords: Superoxide dismutase; Pseudoalteromonas haloplanktis; Psychrophilic enzyme; Sulfhydryl reactivity; Covalent modificationβme-PhSOD, PhSOD purified in the presence of β-mercaptoethanol; EcSOD, Fe-SOD from Escherichia coli; ESI, electrospray ionization; IC50

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه

Novel inhibitors of the trypanosome alternative oxidase inhibit Trypanosoma brucei brucei growth and respiration

Keywords: TAO; trypanosome alternative oxidase; rTAO; recombinant trypanosome alternative oxidase; AOX; alternative oxidase; SHAM; salicylhydroxamic acid; IPTG; isopropyl β-D-thiogalactopyranoside; DTT; dl-dithiothreitol; β-NADH; β-nicotinamide adenine dinucleot

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه

Chronic Myeloid Leukemia: Diagnosis and Treatment

Keywords: ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; AP; accelerated phase; ATP; adenosine triphosphate; BP; blast phase; CCGR; complete cytogenetic response; CHR; complete hematologic response; CML; chronic myeloid leukemia; CP; chronic phase;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2006 سفارش ترجمه

Assessing the proarrhythmic potential of drugs: Current status of models and surrogate parameters of torsades de pointes arrhythmias

Keywords: AP; action potential; IC50; concentration at 50% inhibition; TdP; torsades de pointes; Ventricular arrhythmias; Guidelines; IKr; Drug effects; QT prolongation; Repolarisation;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2006 سفارش ترجمه

(28) Structural insights into AChE inhibition by monoclonal antibodies

Keywords: AChE; acetylcholinesterase (BgAChE, from Bungarus fasciatus; EeAChE, from Electrophorus electricus; mAChE; from mouse); CDR; complementarity determining region; Fab; mAb fragment; Fv; variable mAb fragment; IC50; inhibitor concentration at 50% activity; m

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2005 سفارش ترجمه

In vitro screening of some Strychnos species for antiplasmodial activity

Keywords: EtOAc; ethyl acetate; IC90; inhibitory concentration 90%; IC50; inhibitory concentration 50%; MeOH; methanol; μM; micromolar; Rh; rhesus; S.D.; standard deviation; Strychnos; Loganiaceae; Antiplasmodial; Malaria; Plasmodium falciparum; In vitro screening

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Antioxidant activity and cytotoxicity of eight plants used in traditional Arab medicine in Israel

Keywords: ANOVA; one-way analysis of variance; DMEM; Dulbecco's modified Eagle's medium; IC50; the concentration at which the extent of lipid peroxidation was suppressed by 50%; LDH; lactate dehydrogenase; MDA; malondialdehyde; MTT; 3-[4,5-dimethylthiazol-2-yl]-2,5

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Inhibition of cell differentiation by quinolones in micromass cultures of rat embryonic limb bud and midbrain cells

Keywords: IC50; a drug concentration causing 50% inhibition; OD; optical density; SD; standard deviation; Quinolones; Developmental toxicity; Micromass culture technique;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

2-Aminoperimidine, a specific inhibitor of bacterial NhaA Na+/H+ antiporters

Keywords: Ec-NhaA and Vc-NhaA; Na+/H+ antiporters of NhaA type from Escherichia coli or Vibrio cholerae, respectively; Ec-NhaB and Vc-NhaB; Na+/H+ antiporters of NhaB type from Escherichia coli or Vibrio cholerae, respectively; Vc-NhaD; Na+/H+ antiporter of NhaD ty

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Ethanol extract of Polygonum cuspidatum inhibits hepatitis B virus in a stable HBV-producing cell line

Keywords: α-SMA; α-smooth muscle actin; CC50; cytotoxic concentration of 50%; DMSO; dimethyl sulfoxide; ELISA; enzyme linked immunosorbent assay; HBV; hepatitis B virus; HBeAg; e antigen of HBV; HBsAg; surface antigen of HBV; HCC; hepatocellular carcinoma; IC50;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Inhibitory effects of cinnamic acid and its derivatives on the diphenolase activity of mushroom (Agaricus bisporus) tyrosinase

Keywords: DMSO; dimethyl sulfoxide; l-DOPA; l-3,4-dihydroxyphenylalanine; IC50; the inhibitor concentrations leading to 50% activity lost; Mushroom tyrosinase; Diphenolase activity; Cinnamic acid and its derivatives; Inhibition kinetics;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Validation of a rat behavioral avoidance model from a drug delivery perspective

Keywords: CS; candidate selection; IC50; concentration causing a 50% decrease in licking frequency; LO; lead optimization; SOA; sucrose octaacetate; Sumatriptan; Fluoxetine; Ergotamine; Bitter taste; Rat model; Migraine therapy;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Cytotoxicity and induction of protective mechanisms in HepG2 cells exposed to cadmium

Keywords: CdCl2 · H2O; Cd; BSA; bovine serum albumin; ΔOD; increment of optical densities; FBS; foetal bovine serum; ICP-AES; Inductively coupled plasma-atomic emission spectrometry; MT; metallothioneins; OD; optical density; PBS; phosphate buffered saline; PMS

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

An interspecies comparison of mercury inhibition on muscarinic acetylcholine receptor binding in the cerebral cortex and cerebellum

Keywords: Humans; Rats; Mice; River otter; Mink; Wildlife; Neurotoxicology; Methylmercury; Inorganic mercury; Cholinergic system; Receptor binding; Saturation binding curves; IC50; Comparative study; Cross species; In vitro;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Analgesic-antiinflammatory properties of Proustia pyrifolia

Keywords: Proustia pyrifolia; Analgesic-antiinflammatory-toxicity; Steroids-flavonoids; A; antinflammatory activity; AA; arachidonic acid; ADR; adriamicyn; AL; allopurinol; An; analgesic effect; A-549; human lung carcinoma; CC; column chromatography; Ccontrol;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Acrolein in cigarette smoke inhibits T-cell responses

Keywords: Cigarette smoke; T cell; activation; cytokine; gene expression; acrolein; CSE; Cigarette smoke extract; GC/MS; Gas chromatography/mass spectroscopy; IC50; Inhibitory concentration of 50%;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

Pharmacodynamic interaction of naproxen with low-dose aspirin in healthy subjects

Keywords: AA; arachidonic acid; BID; twice-daily dosing; CI; confidence interval; COX; cyclooxygenase; IC50; concentrations required to inhibit 50% of enzyme activity; NANSAIDs; nonaspirin nonsteroidal anti-inflammatory drugs; NSAIDs; nonsteroidal anti-inflammatory

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

Development of a novel method for screening of estrogenic compounds using nano-sized bacterial magnetic particles displaying estrogen receptor

Keywords: BMPs; bacterial magnetic particles; E2; 17β-estradiol; ERLBD; estrogen receptor ligand binding domain; ALP-E2; alkaline phosphatase conjugated 17β-estradiol; RI; radioisotope; ERLBD-BMPs; ERLBD displayed onto BMPs; IC50; concentration of 50% inhibition;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

Comparative quantification of pharmacodynamic parameters of chiral compounds (RRR- vs. all-rac-α tocopherol) by global gene expression profiling

Keywords: Biopotency; Gene expression; Pharmacodynamic; Tocopherol; Vitamin E; All-rac-α-T; All-rac-α-tocopherol; All-rac-α-Tac; All-rac-α-tocopheryl acetate; EC50; Effective concentration; HPLC; High performance liquid chromatography; IC50; Inhibitory concentr

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

Activation of the complement system and leukocyte recruitment by Tityus serrulatus scorpion venom

Keywords: AP; alternative pathway; CFD; complement fixation diluent; CP; classical pathway; CS; complement system; IC50; venom concentration inhibiting 50% of the lytic activity; NHS; normal human serum; PBS; Phosphate-buffered saline; TEA; triethanolamine; TsV; Ti

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Angiotensin-Converting Enzyme Inhibitory Activity of Peptides Derived from Caprine Kefir

Keywords: angiotensin-converting enzyme-inhibitory activity; caprine kefir; simulated gastrointestinal digestion; mass spectrometry; ACE; angiotensin-converting enzyme; IC50; protein concentration needed to inhibit the original ACE activity by 50%; MS/MS; tandem ma

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه