کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9011308 | 1124146 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antioxidant activity and cytotoxicity of eight plants used in traditional Arab medicine in Israel
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کلمات کلیدی
MDADMEMTBARSIC503-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide - 3- [4،5-dimethylthiazol-2-yl] -2،5-difenyl tetrazolium bromideDulbecco's modified Eagle's medium - Medal of Eagle اصلاح شده DulbeccoMTT - MTTDiabetes - بیماری قندLiver disease - بیماریهای کبدیANOVA - تحلیل واریانس Analysis of varianceone-way analysis of variance - تحلیل واریانس یک راههOxidative stress - تنش اکسیداتیوCytotoxicity - سمیت سلولیlactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH malondialdehyde - مالون دی آلدهیدthiobarbituric acid reactive substances - مواد واکنش پذیر اسید تیوباربیتوریکAntioxidant potential - پتانسیل آنتی اکسیدان
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Antioxidant activity and cytotoxicity of eight plants used in traditional Arab medicine in Israel Antioxidant activity and cytotoxicity of eight plants used in traditional Arab medicine in Israel](/preview/png/9011308.png)
چکیده انگلیسی
Ethnopharmacological surveys conducted among herbal practitioners of traditional Arab medicine in Israel and the Palestinian area have revealed a large number of indigenous plant species are used as sources of their herbal therapies. Some of these herbal therapies are used to treat liver disease, jaundice or diabetes, conditions in which oxidative stress is prominent. No laboratory data on the bioactivity of herbal medicines in these settings exist in traditional Arab medicine. We hypothesized that the beneficial effect of these plants might be due to their antioxidant properties. Accordingly, we selected eight plants used to treat these two conditions and assessed their antioxidant potential by measuring their ability to suppress the extent of iron-induced lipid peroxidation in rat liver homogenates and their potential toxicity by evaluating their effects on mitochondrial respiration and cell membrane integrity in cultured PC12 and HepG2 cells. We found that all the extracts can suppress iron-induced lipid peroxidation and are not toxic. Of these extracts, those prepared from Teucrium polium and Pistacia lentiscus were the most effective in suppressing iron-induced lipid peroxidation. Further investigations are now needed to establish the exact mechanism of action and identify the active bio-ingredient(s) of each extract in order to explain their therapeutic efficacy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 99, Issue 1, 13 May 2005, Pages 43-47
Journal: Journal of Ethnopharmacology - Volume 99, Issue 1, 13 May 2005, Pages 43-47
نویسندگان
Predrag Ljubuncic, Hassan Azaizeh, Irina Portnaya, Uri Cogan, Omar Said, Khalid Abu Saleh, Arieh Bomzon,