In vitro derivation of interferon-γ producing, IL-4 and IL-7 responsive memory-like CD4+ T cells
Keywords: Memory; CD4 T lymphocytes; In Vitro; IL-4; IL-7;
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The protective and healing effects of Si Shen Wan in trinitrobenzene sulphonic acid-induced colitis
Keywords: MPO; myeloperoxidase; MDA; Malondialdehyde; GSH-PX; Glutathione Peroxidase; SOD; superoxide dismutase; IL-4; Interleukin-4; IL-10; Interleukin-10; IBD; Inflammatory bowel disease; UC; ulcerative colitis; CD; crohn's disease; 05-ASA; 5-aminosalicylic acid;
CD4+CD25+ T cells expressing FoxP3 in Icelandic horses affected with insect bite hypersensitivity
Keywords: Icelandic horses; Insect bite hypersensitivity; Allergy; FoxP3; IL-4;
Antigen-specific IFN-gamma and IL-4 production in caprine herpesvirus infected goats
Keywords: Goat; PBMC; CpHV-1; IFN-gamma; IL-4; ELISA; ELISPOT; Cross-reactivity;
Inflammatory effects on human lung epithelial cells after exposure to diesel exhaust micron sub particles (PM1.0) and pollen allergens
Keywords: Asthma; Sub-micron PM particles; IL-4; IL-5; IL-13
Beneficial effect of garlic on d-galactosamine and lipopolysaccharide-induced acute hepatic failure in male albino rats
Keywords: Acute hepatic failure; D-GalN; LPS; TNF-alpha; IL-4; Leukocytes;
Protective immunization of hamsters against Opisthorchis viverrini infection is associated with the reduction of TGF-β expression
Keywords: Opisthorchis viverrini; Hamster; IL-10; IL-4; TGF-β; IFN-γ;
Induction of an anti-inflammatory human monocyte subtype is a unique property of glucocorticoids, but can be modified by IL-6 and IL-10
Keywords: GC, glucocorticoids; IL, interleukin; ROS, reactive oxygen species; DC, dendritic cells; LPS, lipopolysaccharide; IFN, interferonMonocytes; Macrophages; Glucocorticoids; Cytokines; IL-4; Apoptosis
Up-regulation of IL-33 expression in various types of murine cells by IL-3 and IL-4
Keywords: IL; interleukin; LPS; lipopolysaccharide; PMA; phorbol myristate acetate; SCF; stem cell factor; IL-33 intracrine; IL-3; IL-4; Macrophages; Fibroblasts;
Expression of CD200 in alternative activation of microglia following an excitotoxic lesion in the mouse hippocampus
Keywords: CD200; Alternative activation; Microglia; Kainic acid; Hippocampus; IL-4
Ubiquitin released in the plasma of whole blood during storage promotes mRNA expression of Th2 cytokines and Th2-inducing transcription factors
Keywords: TRIM; transfusion-related immunomodulation; Ub; ubiquitin; ELISA; enzyme-linked immunosorbent assay; PBMNC; peripheral blood mononuclear cells; CCK-8; cell counting kit-8; Extracellular ubiquitin; Transfusion-related immunomodulation; IL-4; IFN-γ; STAT6;
STAT6 and JAK1 are essential for IL-4-mediated suppression of prostaglandin production in human follicular dendritic cells: Opposing roles of phosphorylated and unphosphorylated STAT6
Keywords: FDC; follicular dendritic cell; GC; germinal center; JAK; Janus kinase; STAT; signal transducer and activator of transcription; U-STAT6; unphosphorylated STAT6; P-STAT6; phosphorylated STAT6; Follicular dendritic cells; IL-4; STAT6; COX-2; Prostaglandin;
Stat6 activity-related Th2 cytokine profile and tumor growth advantage of human colorectal cancer cells in vitro and in vivo
Keywords: Colorectal cancer; IL-4; Stat6; Th1/Th2/Th17 cytokines; Tumor immunity;
Human intestinal mast cells are a potent source of multiple chemokines
Keywords: Mast cells; Chemokines; IgE; IL-4; SCF;
Helminthic therapy: improving mucosal barrier function
Keywords: helminthic therapy; TH2 response; immune regulation; mucosal immunity; mucus; IL-4; IL-22; microbiome
Seasonal population of Acarus siro mites and effects of their faeces on allergenic immunological disorder modulated by garlic in albino rat
Keywords: Acarus siro faeces; Allergenic immune response; IgE; IL-4; INF-γ;
The association between the IL-4, ADRβ2 and ADAM 33 gene polymorphisms and asthma in the Taiwanese population
Keywords: ADAM33; asthma; β2 adrenergic receptor; IL-4; single nucleotide polymorphism (SNP)
Revision joint replacement, wear particles, and macrophage polarization
Keywords: M1 M2 macrophages; Osteolysis; Total joint replacement; PMMA; IL-4;
Lack of signaling by IL-4 or by IL-4/IL-13 has more attenuating effects on Leishmania amazonensis dorsal skin - than on footpad-infected mice
Keywords: IL-4; IL-13; Leishmania amazonensis; IL-4 receptor alpha;
Safety Science ArticleIdentification of contact and respiratory sensitizers according to IL-4 receptor α expression and IL-2 production
Keywords: Chemical contact and respiratory sensitizers; Flow cytometry; IgE-positive B cells; IL-2; IL-4; IL-4Rα;
Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; CTLA-4; cytotoxic T-lymphocyte antigen 4; FACS; fluorescence-activated cell sorting; Foxp3; forkhead-box transcription factor; GFP; green fluorescent protein; IL-4; interleukin 4; IL-10; interle
Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice
Keywords: Microglia; Aging; IL-4; IL-10; M1 and M2 activation profiles;
Stem cells as the root of pancreatic ductal adenocarcinoma
Keywords: ABC; ATP binding cassette; ALDH1; Aldehyde dehydrogenase 1a1; Arx; Aristalless-related homeobox; EMT; Epithelial-to-mesenchymal transition; CAC; Centroacinar cells; CD; Cluster of differentiation; CDKN2A; Cyclin-dependent kinase inhibitor 2A; CSC; Cancer
Basophils and mast cells: Underdog in immune regulation?
Keywords: Mast cells; Basophilic granulocytes; Basophils; TNF; IgE; IL-4
Changes in intramuscular cytokine levels during masseter inflammation in male and female rats
Keywords: Complete Freund's adjuvant; TNF-α, IL-1β; IL-6; IL-4; Sex; Muscle;
Leishmania chagasi: Effect of the iron deficiency on the infection in BALB/c mice
Keywords: Leishmania chagasi; Iron deficiency; BALB/c; Visceral leishmaniasis; Hemoglobin; IFN-gamma; IL-4;
Dihydroartemisinin shift the immune response towards Th1, inhibit the tumor growth in vitro and in vivo
Keywords: DTH, delayed type hypersensitivity; SMMT, spontaneous mouse mammry tumor; FBS, fetal bovine serum; sRBC, sheep red blood cells; MNCs, mononuclear cells; DHA, dihydroartemisininDihydroartemisinin; T regulatory cell (Treg cell); IFN-γ; IL-4; Immuno-modulato
Inonotus obliquus extracts suppress antigen-specific IgE production through the modulation of Th1/Th2 cytokines in ovalbumin-sensitized mice
Keywords: OVA; ovalbumin; ConA; concanavalin A; LPS; lipopolysaccharide; IL-4; interleukin-4; IFN-γ; interferon-γ; IL-2; interleukin-2; NO; nitric oxide; TNF-α; tumor necrosis factor-α; IO; Inonotus obliquus; Ig; immunoglobulin; IOE; Inonotus obliquus hot water
Inhibitory effects of Chelidonium majus extract on atopic dermatitis-like skin lesions in NC/Nga mice
Keywords: AD; atopic dermatitis; CM; Chelidonium majus; IL-4; interleukin-4; IgE; immunoglobulin E; TNF-α; tumor necrosis factor-α; DNCB; 1-chloro-2,4-dinitrobenzene; NOR; normal group; CON; control group; CMP 1; Chelidonium majus Methanol Extract 100 mg/kg, p.o
SOCS3 suppresses the expression of IL-4 cytokine by inhibiting the phosphorylation of c-Jun through the ERK signaling pathway in rat mast cell line RBL-2H3
Keywords: SOCS3, suppressor of cytokine signaling; shRNA, small hairpin RNA; EGFP, enhanced green fluorescent proteinSOCS3; IL-4; ERK; ERK1/2; c-Jun; AP-1; Negative feedback; Allergy; PG102; RBL-2H3; Mast cell
Shikonin inhibited mitogen-activated IL-4 and IL-5 production on EL-4 cells through downregulation of GATA-3 and c-Maf induction
Keywords: Shikonin; TH2 cells; GATA-3; c-Maf MAPK; IL-4;
Adipose derived stem cells (ASCs) isolated from breast cancer tissue express IL-4, IL-10 and TGF-β1 and upregulate expression of regulatory molecules on T cells: Do they protect breast cancer cells from the immune response?
Keywords: Adipose derived stem cells (ASCs); Breast cancer; Tumor microenvironment; IL-10; IL-4; TGF-β1
Pathogenetic factors for excessive IgA production: Th2-dominated immune response in canine steroid-responsive meningitis-arteritis
Keywords: CNS immune response; Dog; Humoral immune response; IL-4; T Helper 2 cells; SRMA
Effects of inactivated parapoxvirus ovis on the cumulative incidence of pneumonia and cytokine secretion in foals on a farm with endemic infections caused by Rhodococcus equi
Keywords: Equine; Foal; IFN-γ; IL-4; Pneumonia; Rhodococcus equi;
IL-4 mediates dicloxacillin-induced liver injury in mice
Keywords: 13,14-Dihydro-15-keto-prostaglandin D2; Drug-induced liver injury; IL-4
Cantharidin modulates development of human monocyte-derived dendritic cells
Keywords: APCs; professional antigen-presenting cells; CFSE; carboxyfluorescein succinimidyl ester; CTD; cantharidin; DCs; dendritic cells; FITC; fluorescein isothiocyanate; GI; gastrointestinal tract; IFN-γ; interferon-γ; IL-4; interleukin-4; PP1; protein phosph
Adaptive cytokine production in early life differentially predicts total IgE levels and asthma through age 5 years
Keywords: Asthma; IgE; cytokines; IL-4; IL-5; IL-13; IFN-γ; children;
α-Cyclodextrin enhances myoblast fusion and muscle differentiation by the release of IL-4
Keywords: α-Cyclodextrin; Methyl-β-cyclodextrin; Myoblast fusion; IL-4; Myogenin;
Brain homeostasis is maintained by “danger” signals stimulating a supportive immune response within the brain’s borders
Keywords: Brain homeostasis; Danger signal; Adaptive immunity; IL-4; Detoxification; Glyoxalase
Topical application of porcine placenta extract inhibits the progression of experimental contact hypersensitivity
Keywords: PE; placenta extract; LPS; lipopolysachharide; TNF-α; tumor necrosis factor alpha; IL-1β; interleukin 1 beta; IFN-γ; interferon gamma; IL-4; interleukin 4; IL-6; interleukin 6; IL-2; interleukin 2; IL-17; interleukin 17; CHS; contact hypersensitivity;
Pro- and anti-inflammatory control of M-CSF-mediated macrophage differentiation
Keywords: CSF, colony stimulating factor; M-CSF, macrophage colony stimulating factor; IFN, interferon; IL, interleukin; TNF, tumour necrosis factor; LPS, lipopolysaccharideDifferentiation; Glucocorticoid; IFN-γ; IL-4; Inflammation; Macrophage
Interleukin(IL)-4 promotion of CXCL-8 gene transcription is mediated by ERK1/2 pathway in human pulmonary artery endothelial cells
Keywords: IL-4; CXCL-8; Endothelial cells; ERK1/2; NF-κB;
Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel
Keywords: IRF-4; interferon regulatory factor-4; IFN; interferon; ISRE; IFN-stimulated response element; TCR; T-cell receptor; PMA; phorbol-12-myristate-13-acetate; I; Ionomycin; TAP; tandem affinity purification; IL-4; interleukin-4; HTLV-1; human adult T-cell leu
Immune responses in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus
Keywords: PRRSV; Highly pathogenic PRRSV; IL-4; IL-10; Immune responses
Ethyl acetate extract of Psidium guajava inhibits IgE-mediated allergic responses by blocking FcεRI signaling
Keywords: Psidium guajava; Anti-allergic activity; Mast cells; IL-4; NF-κB; Syk;
Non-FcεR bearing mast cells secrete sufficient interleukin-4 to control Francisella tularensis replication within macrophages
Keywords: Mast cells; IL-4; Respiratory infection; Francisella tularensis; Innate immunity;
Downregulation of basophil-derived IL-4 and in vivo TH2 IgE responses by serotonin and other organic cation transporter 3 ligands
Keywords: Basophils; IL-4; TH2-type immune response; organic cation transporter 3; 5-HT; 5-Hydroxytryptamine; BMC; Bone marrow cell; BMDB; Bone marrow-derived basophil; CYP450; Cytochrome P450; Dat; Dopamine transporter; DNP; Dinitrophenyl; Gapdh; Glyceraldehyde-
Cloning of guinea pig IL-4: Reduced IL-4 mRNA after vaccination or Mycobacterium tuberculosis infection
Keywords: IL-4; Guinea pig; PMA; BCG; M. tuberculosis;
Poxvirus interleukin-4 expression overcomes inherent resistance and vaccine-induced immunity: Pathogenesis, prophylaxis, and antiviral therapy
Keywords: Immunosuppression; Poxvirus; Ectromelia virus; Lethal infection; IL-4