4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists
Keywords: Liver X receptor; LXR; Quinoline; Sulfone; ABCA1; Atherosclerosis; Lipid; Cholesterol
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Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation
Keywords: RXR agonists; Permissive heterodimers; PPAR; LXR; Carboxylic analogues; Docking simulation
1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists
Keywords: Benzimidazole; Sulfone; ABCA1; LXR; Liver X receptor; Cholesterol; Lipid; Atherosclerosis
Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists
Keywords: Liver X receptor; LXR; Quinoline; Sulfone; ABCA1; Atherosclerosis; Lipid; Cholesterol
3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists
Keywords: Imidazo[1,2-a]pyridine; Liver X receptor; LXR; Atherosclerosis; Sulfone; ABCA1; Cholesterol; Triglycerides
Sirtuins regulate key aspects of lipid metabolism
Keywords: SIRT1; Lipid; Metabolism; PPARα; PGC-1α; LXR
LXRβ deficient mice have reduced hepatic insulin clearance during hyperinsulinemic euglucemic clamp
Keywords: Glucose; Insulin; Hepatic steatosis; LXR; Insulin clearance
Functional crosstalk of CAR–LXR and ROR–LXR in drug metabolism and lipid metabolism
Keywords: Nuclear receptor; LXR; CAR; ROR; Drug metabolism; Lipid metabolism; Gene regulation
PPARγ activates ABCA1 gene transcription but reduces the level of ABCA1 protein in HepG2 cells
Keywords: ABCA1, ATP-binding cassette transporter A1; HDL, high-density lipoproteins; LXR, liver X receptor; LXRE, LXR response element; PPAR, peroxisome proliferator-activated receptorABCA1; HDL; LXR; MEK1/2; PPARγ
Oxysterol represses high-affinity IgE receptor-stimulated mast cell activation in Liver X receptor-dependent and -independent manners
Keywords: BMMCs; bone marrow-derived mast cells; FcεRI; high-affinity IgE; LXR; liver X receptor; LDLR; LDL receptor; 25-OHC; 25-hydroxycholesterol; 22(R)-OHC; 22(R)-hydroxycholesterol; 24(S),25-EC; 24(S),25-epoxycholesterol; 22(S)-hydroxycholesterol; (22(S)-OHC);
Activation of the nuclear receptor PPARγ by metabolites isolated from sage (Salvia officinalis L.)
Keywords: DCM; dichloromethane; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; EtOAc; ethyl acetate; FXR; farnesoid X receptor; HDL; high-density lipoprotein; HPLC; high performance liquid chromatography; LBD; ligand binding domain; LDL; low-de
LXRα regulates human CETP expression in vitro and in transgenic mice
Keywords: CETP; LXR; HDL; LDL
Fatty liver: Role of inflammation and fatty acid nutrition
Keywords: NEFA; nonesterified fatty acid; HSL; hormone sensitive lipase; LPL; lipoprotein lipase; VLDL; very-low density lipoprotein; n-3 PUFA; omega - 3 polyunsaturated fatty acid; SREBP-1c; sterol regulatory element binding protein-1c; ACC; acetyl CoA carboxy
The nuclear receptor FXR is expressed in pancreatic β-cells and protects human islets from lipotoxicity
Keywords: BA; bile acids; BSA; bovine serum albumin; FGF; fibroblast growth factor; GSCN; guanidinium thiocyanate; FXR; farnesoid X receptor; GSIS; glucose-stimulated insulin secretion; IAPP; islet amyloid polypeptide; IPGTT; intraperitoneal glucose tolerance test;
A second class of nuclear receptors for oxysterols: Regulation of RORα and RORγ activity by 24S-hydroxycholesterol (cerebrosterol)
Keywords: Cholesterol; LXR; Lipid; REV-ERB; Circadian; Orphan receptor;
Effect of TNFα on activities of different promoters of human apolipoprotein A-I gene
Keywords: HDLs; high density lipoproteins; ApoA-I; apolipoprotein A-I; TNFα; tumour necrosis factor α; TSP; transcription start point; CP; canonical apoA-I promoter; PAP; proximal alternative promoter; DAP; distal alternative promoter; HE; hepatic enhancer; HDLs;
Differential effects of activation of liver X receptor on plasma lipid homeostasis in wild-type and lipoprotein clearance-deficient mice
Keywords: LXR; VLDL; LPL; Lipoprotein clearance deficiency; Triglycerides
High-density lipoprotein therapeutics and cardiovascular prevention
Keywords: apoAI; CETP; Cholesterol efflux; HDL; LXR; Reverse cholesterol transport
Tryptase promotes human monocyte-derived macrophage foam cell formation by suppressing LXRα activation
Keywords: Tryptase; Macrophage; Foam cell; PAR-2; LXR;
Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids
Keywords: AA; arachidonic acid; ABCA1; ATP binding cassette transporter A1; ABCG1; ATP binding cassette transporter G1; apoA1; apolipoproteinA1; apoE; apolipoproteinE; BSA; bovine serum albumin; CE; carboxylesterase; CES1; carboxylesterase 1; CES2; carboxylesterase
Eicosapentaenoic acid improves hepatic steatosis independent of PPARα activation through inhibition of SREBP-1 maturation in mice
Keywords: ACC; acetyl-CoA carboxylase; ALT; alanine aminotransferase; apo; apolipoprotein; AOX; acyl-CoA oxidase; AST; aspartate aminotransferase; CoA; coenzyme A; CPT-I; carnitine palmitoyl-CoA transferase-I; EPA; eicosapentaenoic acid; FA; fatty acid; FAS; fatty
Murine atopic dermatitis responds to peroxisome proliferator-activated receptors α and β/δ (but not γ) and liver X receptor activators
Keywords: Atopic dermatitis; barrier function; liver X receptor; mouse model; peroxisome proliferator-activated receptor α, β/δ, and γ; TH2 cells; AD; Atopic dermatitis; CRTH; Chemoattractant receptor-homologous molecule expressed on TH2; LXR; Liver X recep
Cross-talk between adipose and gastric leptins for the control of food intake and energy metabolism
Keywords: ACTH; adrenocorticotropic hormone; ADIPOR1/2; adiponectin receptor1/2; AgRP; agouti related protein; AMPK; AMP-activated protein kinase; BSDL; bile salt-dependent lipase; cAMP; cyclic adenosine-monophosphate; CART; cocaine amphetamine related transcript;
Suppression of interleukin-6-induced C-reactive protein expression by FXR agonists
Keywords: FXR; farnesoid X receptor; SHP; small heterodimer partner; CRP; C-reactive protein; SAP; serum amyloid P component; SAA; serum amyloid A; APP; acute-phase protein; IL-6; interleukin-6; IL-1; interleukin-1; PPAR-α; peroxisome proliferator-activated recept
Synthesis and SAR of potent LXR agonists containing an indole pharmacophore
Keywords: LXR; Liver X receptors; Nuclear hormone receptors; Pulmonary inflammation; Diabetes; Atherosclerosis
Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator
Keywords: LXR; Selective modulators; HDL-cholesterol; TG
The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages
Keywords: LXR; Liver X receptor; HDL-c; LDL-c; VLDL-c; Triglycerides; Adenosine triphosphate binding cassette; ABC transporter; ABCA1; ABCG1; SREBP1c; Epoxycholesterol; Atherosclerosis; LXR modulator
New functions of cholesterol binding proteins
Keywords: Cholesterol binding protein; LXR; NPC1; Mechanisms
4-(3-Aryloxyaryl)quinoline alcohols are liver X receptor agonists
Keywords: Liver X receptor; LXR; Quinoline; Alcohol; Biarylether; ABCA1
The conjugated linoleic acid isomer trans-9,trans-11 is a dietary occurring agonist of liver X receptor α
Keywords: CLA; Gene expression; LXR; Macrophages; Nuclear receptor
Biarylether amide quinolines as liver X receptor agonists
Keywords: Liver X receptor; LXR; Agonist; Quinoline; ABCA1
Transport of fatty acids across the human placenta: A review
Keywords: Placenta; Fatty acids; Plasma membrane fatty acid-binding proteins; Fatty acid transporter protein; Fatty acid translocase; Long chain polyunsaturated fatty acids; Fetus; Brain; Trophoblast; Human placenta; EFA; Nuclear transcription factors; ACSBG; acylC
Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor
Keywords: AHR, aryl hydrocarbon receptor; ARE, antioxidant response element; BaP, benzo[a]pyrene; BCRP, breast cancer resistance protein; BSEP, bile salt export pump; CAR, constitutive androstane receptor; FXR, farsenoid X receptor; GR, glucocorticoid receptor; LXR
The role of herbal PPAR modulators in the treatment of cardiometabolic syndrome
Keywords: Herbal; Natural Ligands; PPAR; LXR; FXR; Peroxisome proliferator-activated receptors; Liver X receptors; Farnesoid X receptor
ReviewKupffer cells in non-alcoholic fatty liver disease: The emerging view
Keywords: Steatohepatitis; Macrophages; Toll-like receptors; Adiponectin; Uncoupling protein; DAMP; damage-associated molecular pattern; LPS; lipopolysaccharide; LXR; liver X receptor; NAFLD; non-alcoholic fatty liver disease; NASH; non-alcoholic steatohepatitis; P
New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism
Keywords: ACAT; acyl-CoA:cholesterol acyltransferase; ABC; adenosine triphosphate-binding cassette transporter; ANXA2-CAV1; annexin 2/caveolin 1; apo; apolipoprotein; CVD; cardiovascular disease; CYP7A1; cytochrome P450 family 7 subfamily A polypeptide 1; FPPS; f
Identification of cis-acting promoter sequences required for expression of the glycerol-3-phosphate acyltransferase 1 gene in mice
Keywords: GPAT1; glycerol-3-phosphate acyltransferase 1; USF-1; upstream stimulatory factor-1; SREBP-1; sterol regulatory element-binding protein-1; ORF; open reading frame; 5â²-RACE; 5â²-Rapid amplification of cDNA ends; siRNA; small interfering RNA; EMSA; Elect
Analysis of neurosterols by GC–MS and LC–MS/MS
Keywords: Sterol; Mass spectrometry; Lipidomics; Cholesterol; Alzheimer's disease; LXR; Brain; Oxysterol
PPARα gene expression is up-regulated by LXR and PXR activators in the small intestine
Keywords: GW3965; LXR; PCN; PPARα; PXR; T0901317; Transcriptional regulation; Lipid metabolism
Treatment with LXR agonists after focal cerebral ischemia prevents brain damage
Keywords: LXR; liver X receptor; ABCA1; ATP-binding cassette A1; SREBP; sterol regulated-element binding protein; MRI; magnetic resonance imaging; Acute cerebral ischemia; Experimental therapy; Neuroprotection; Nuclear receptor; Transcriptional activator;
Effects of oleic acid and macrophage recruitment on cholesterol efflux in cell culture and in vivo
Keywords: Macrophages; Oleic acid; LXR; ABCG1; HDL; Atherosclerosis regression
Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood–brain barrier
Keywords: ABC transporter; Blood–brain barrier; Brain capillary endothelial cell; Nuclear receptor; LXR; PPAR; PXR
Role of ChREBP in hepatic steatosis and insulin resistance
Keywords: ChREBP; LXR; Hepatic steatosis; Insulin resistance; ob/ob Mice
Fluctuation of lipoprotein metabolism linked with bile acid-activated liver nuclear receptors in Alagille syndrome
Keywords: Cholestasis; HDL; Apolipoprotein E; FXR; LXR; SR-BI; CETP
Serum sterols in patients with primary biliary cirrhosis and acute liver failure before and after liver transplantation
Keywords: LTX; liver transplantation; ALF; acute liver failure; PBC; primary biliary cirrhosis; ABC; adenosine triphosphate-binding cassette; ATP; adenosine triphosphate; NPC1L1; Niemann-Pick C1-like 1 protein; LXR; liver X receptor; MARS; molecular adsorbent immun
Nuclear receptors in macrophages: A link between metabolism and inflammation
Keywords: PPAR-γ, peroxisome proliferator-activated receptor γ; LXR, liver X receptor; DC, dendritic cell; IFN, interferon; IL, interleukin; LDL, low density lipoprotein; LDLR, LDL receptor; SR, scavenger receptorNuclear receptor; Inflammation; PPAR-γ; LXR; Atheros
Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis
Keywords: Acc-1; acetyl CoA carboxylase 1; DTg; double transgenic; Fae; long-chain free fatty acid elongase; Fas; fatty acid synthase; FFA; free fatty acid; HA; hemagglutinin; LXR; liver X receptor; PCN; pregnenolone-16α-carbonitrile; PPAR; peroxisome proliferator
Bioactive lipids in metabolic syndrome
Keywords: ABCA1; ATP-binding cassette transporter A1; ACC; acetyl-CoA carboxylase; ACO; acyl-CoA oxidase; CDHA; conjugated DHA; CEPA; conjugated EPA; CFAs; conjugated fatty acids; CLA; conjugated LA; CLN; conjugated LNA; CPT; carnitine palmitoyltransferase; CYP7A1;
Regulation of central nervous system cholesterol homeostasis by the liver X receptor agonist TO-901317
Keywords: LXR; TO-901317; Synaptosomal plasma membrane (SPM); Cholesterol; CNS; Brain; Efflux
Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia
Keywords: RXR; LXR; Dyslipidemia; ABCA-1; Triglycerides