دانلود مقالات ISI درباره هدف مکانیکی رپامایسین + ترجمه فارسی

Takeda G Protein-Coupled Receptor 5-Mechanistic Target of Rapamycin Complex 1 Signaling Contributes to the Increment of Glucagon-Like Peptide-1 Production after Roux-en-Y Gastric Bypass

Keywords: هدف مکانیکی رپامایسین; BAs; Bile acids; Cyp7a1; Cytochrome P450 family 7 subfamily A member 1; DCA; Deoxycholic acid; FXR; Farnesoid X receptor; GLP-1; Glucagon-like peptide-1; ip; Intraperitoneal; mTOR; mechanistic target of rapamycin; mTORC1; mechanistic target of rapamycin c

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

Activation of Serine One-Carbon Metabolism by Calcineurin Aβ1 Reduces Myocardial Hypertrophy and Improves Ventricular Function

Keywords: هدف مکانیکی رپامایسین; cardiac function; cell signaling; hypertrophy; metabolism; ATF4; activating transcription factor 4; BSO; L-buthionine-sulfoximine; GSH; reduced glutathione; LVEF; left ventricular ejection fraction; LVMi; left ventricular mass index; mTOR; mechanistic tar

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

CCRK is a novel signalling hub exploitable in cancer immunotherapy

Keywords: هدف مکانیکی رپامایسین; 9G8; serine and arginine rich splicing factor 7; AKT; AKT serine/threonine kinase; AR; androgen receptor; ARE; androgen response element; ARG1; arginase 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3-related protein; BMDC; mous

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds

Keywords: هدف مکانیکی رپامایسین; AMPK; adenosine monophosphate-activated protein kinase; APAB; 2,2′-azo-bisamidinopropane; BSA; bovine serum albumin; CCL4; carbon tetrachloride; DMEM; Dulbecco's modified eagle's medium; DMSO; dimethyl sulfoxide; DTPA; diethylenetriaminepentaacetic acid

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2018 سفارش ترجمه

Can we increase the speed and efficacy of antidepressant treatments? Part II. Glutamatergic and RNA interference strategies

Keywords: هدف مکانیکی رپامایسین; Ketamine; microRNA; Prefrontal cortex; Small interfering RNA; RNA interference; 5-HT; serotonin; 5-HT1A receptor; serotonin 1A receptor; A1; adenosine A1 receptor; AchE; acetylcholinesterase; AGO; argonaute; Akt-mTOR; protein kinase B/Akt- mammalian targe

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2018 سفارش ترجمه

Bavachalcone from Cullen corylifolium induces apoptosis and autophagy in HepG2 cells

Keywords: هدف مکانیکی رپامایسین; C. corylifolium; Bavachalcone; Apoptosis; Cell cycle; Autophagy; CCE; Cullen corylifolium ethanol extract; HCC; hepatocellular carcinoma; NAFLD; Nonalcoholic fatty liver disease; Bax; bcl-2-associated X protein; Bcl-2; b-cell lymphoma 2; Bid; BH3 interact

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Lpaatδ/Agpat4 deficiency impairs maximal force contractility in soleus and alters fibre type in extensor digitorum longus muscle

Keywords: هدف مکانیکی رپامایسین; AGPAT; acylglycerophosphate acyltransferase; CL; cardiolipin; DGK; diacylglycerol kinases; ETC; electron transport chain; ETS; electron transport system; EDL; extensor digitorum longus; GPAT; acyl-CoA:glycerol-3-phosphate acyltransferase; LPA; lysophospha

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Mapping Txnip: Key connexions in progression of diabetic nephropathy

Keywords: هدف مکانیکی رپامایسین; ARRB; arrestin beta; ARRDC; arrestin domain containing protein; ASK-1; apoptosis signal-regulating kinase-1; Cys; cysteine; ECM; extracellular matrix; FOXO; forkhead box protein; Gly; glycine; IL-1β; interleukin-1 β; JNK; c-Jun-N-terminal kinase; MAPK;

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2018 سفارش ترجمه

SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signalling

Keywords: هدف مکانیکی رپامایسین; SAHA; Suberoylanilide hydroxamic acid; AMPK; AMP-dependent protein kinase; HDAC; histone deacetylase; HDACi; Histone deacetylase inhibitor; mTOR; Mechanistic target of rapamycin; NHEJ; Non-homologous end joining; TSA; Trichostatin A; H3K36; Histone H3 lys

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice

Keywords: هدف مکانیکی رپامایسین; Aβ; Amyloid-β; AD; Alzheimer's disease; ERK2; extracellular signal-regulated kinase 2; IKKβ; Inhibitor of NF-κB kinase β; IRS-1 pSer616; Insulin receptor substrate-1 phosphorylated at serine residue 616; MAPK; mitogen-activated protein kinase; mTOR

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

ER stress and cancer: The FOXO forkhead transcription factor link

Keywords: هدف مکانیکی رپامایسین; Endoplasmic reticulum; ER stress; Cancer; FOXO; Forkhead transcription factors; Unfolded protein response; AKT; Protein Kinase B; AKT1; Protein Kinase B Alpha; AMPK; AMP-activated protein kinase; ASK1; Apoptosis Signal Regulated Kinase 1; ATF4; Activating

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Activation of renal profibrotic TGFβ controlled signaling cascades by calcineurin and mTOR inhibitors

Keywords: هدف مکانیکی رپامایسین; AP-1; activator protein 1; CNI; calcineurin inhibitor(s); ECM; extracellular matrix; EMT; epithelial to mesenchymal transition; ERK; extracellular signal regulated kinase; FKBP; FK506 binding protein; JNK; Jun N-terminal kinase; LAP; latency-associated pr

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Cannabidiol induced apoptosis in human monocytes through mitochondrial permeability transition pore-mediated ROS production

Keywords: هدف مکانیکی رپامایسین; AKT; Protein kinase B; Bcl-2; B-cell lymphoma 2; calcein-AM; calcein-acetoxymethylester; CBD; cannabidiol; CM-H2DCF-DA; 5,6-chloromethyl-2,7-dichlorodihydrofluorescin diacetate; COX IV; cytochrome c oxidase subunit IV; CsA; cyclosporin A; Cyt c; cytochrom

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

α1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes

Keywords: هدف مکانیکی رپامایسین; AMPK; 5′ adenosine monophosphate-activated protein kinase; AR; adrenoceptor; CaMKK; calmodulin-dependent protein kinase kinase; CHO; Chinese hamster ovary; Comp C; compound C; DAG; diacylglycerol; IP3; inositol 1,4,5-trisphosphate; mTOR; mechanistic tar

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

Keywords: هدف مکانیکی رپامایسین; Autophagy; Combination therapy; Erlotinib; Vps34; High-content screening; AKT; Protein kinase B; ATG7; Autophagy-related protein 7; BafA1; Bafilomycin A1; Chk1; Checkpoint kinase 1; CQ; Chloroquine; FGFR; Fibroblast growth factor receptor; GFP; Green fluo

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Folic acid supplementation during pregnancy prevents cognitive impairments and BDNF imbalance in the hippocampus of the offspring after neonatal hypoxia-ischemia

Keywords: هدف مکانیکی رپامایسین; FA; folic acid; NTD; neural tube defects; WHO; World Health Organization; BDNF; brain-derived neurotrophic factor; HI; hypoxia-ischemia; PND; post-natal day; DAB; 3,3'-diaminobenzidine; PBS; phosphate-buffered saline; CA; Cornu Amonis; AOI; area of inte

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Drosophila as a model for ageing

Keywords: هدف مکانیکی رپامایسین; 4EBP; translation initiation factor 4E binding protein; AMPK; AMP activated protein kinase; AOP; anterior open; ATF4; activating transcription factor 4; CHOP; C/EBP homologous protein; CR; calorie restriction; DR; dietary restriction; eIF; eukaryotic tran

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

Multifunctional molecule ERp57: From cancer to neurodegenerative diseases

Keywords: هدف مکانیکی رپامایسین; 1α,25(OH)2D3; 1,25-dihydroxyvitamin D3; ADAM10; a disintegrin and metalloproteinase 10; AIF; apoptosis-inducing factor; AP-1; activator protein 1; ATRA; all-trans retinoic acid; BMP-2; bone morphogenic protein 2; CLNX; calnexin; CRT; calreticulin; ECM; e

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2018 سفارش ترجمه

ERK1/2/mTOR/Stat3 pathway-mediated autophagy alleviates traumatic brain injury-induced acute lung injury

Keywords: هدف مکانیکی رپامایسین; ERK1/2; extracellular signal-regulated kinase 1/2; mTOR; mechanistic target of rapamycin; Stat3; signal transducer and activator of transcription 3; TBI; traumatic brain injury; ALI; acute lung injury; HMGB1; high-mobility group box protein 1; 3-MA; 3‑m

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

Ultraviolet B radiation down-regulates ULK1 and ATG7 expression and impairs the autophagy response in human keratinocytes

Keywords: هدف مکانیکی رپامایسین; UV; ultraviolet; ROS; reactive oxygen species; ATG; autophagy-related gene; MTOR; mechanistic target of rapamycin; ULK1; unc-51-like kinase 1; HEKs; human epidermal keratinocytes; LC3; microtubule-associated protein 1 light chain 3; E&P; E64d and pepstati

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways

Keywords: هدف مکانیکی رپامایسین; ATG; autophagy-related gene; DMEM; Dulbecco's Modified Eagle Medium; GFP; green fluorescent protein; HFD; high fat diet; Ho-1; heme oxygenase-1; Keap1; Kelch-like ECH-associated protein 1; LC3; microtubule-associated protein 1 light chain 3 (MAP1LC3); MCP

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2018 سفارش ترجمه

ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway

Keywords: هدف مکانیکی رپامایسین; Akt; oncogene in the transforming retrovirus, AKT8; AP-1; activator protein 1; ARAF; v-raf murine sarcoma 3611 viral oncogene homologue; ASK1; apoptosis signal-regulating kinase 1; BCL2; B-cell lymphoma 2; BCL-XL; B-cell lymphoma extra large; BRAF; v-raf

دانلود رایگان متن کامل مقاله ISI 68 صفحه سال انتشار : 2018 سفارش ترجمه

Molecular drivers of mitochondrial membrane proliferation in response to cold acclimation in threespine stickleback

Keywords: هدف مکانیکی رپامایسین; AGPAT; 1-acylglycerol 3-phosphate acyltransferase; CDP-DAG; cytidine diphosphodiacylglycerol; CDS; cytidine diphosphodiacylglycerol synthase; CL; cardiolipin; DAG; diacylglycerol; EF-1α; elongation factor-1 alpha; G3P; glycerol 3-phosphate; GPAT; glycero

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

The role of RAS mutations in MLL-rearranged leukaemia: A path to intervention?

Keywords: هدف مکانیکی رپامایسین; ALL; acute lymphoblastic leukaemia; iALL; infant ALL; MLL; myeloid/lymphoid leukaemia or mixed lineage leukaemia, also known as KMT2A; RAS; rat sarcoma; BCP-ALL; B-cell precursor ALL; EFS; event-free survival; OS; overall survival; WBC; white blood cell c

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Hypoxia and HIF pathway in cancer and the placenta

Keywords: هدف مکانیکی رپامایسین; Oxygen; Hypoxia-inducible factor; Placenta; Trophoblast; Cancer; CCRCC; clear cell renal cell carcinoma; FasL; Fas ligand; FIH; factor inhibiting HIF; FLT1; fms-related tyrosine kinase 1; HIF; hypoxia-inducible factor; HLA; human leukocyte antigen; MHC; m

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

H. pylori infection increases gastric mucosal COX2 and mTOR expression in chronic gastritis: Implications for cancer progression?

Keywords: هدف مکانیکی رپامایسین; H. pylori; Helicobacter pylori; GOD; Oesophago-gastroduodenoscopy; COX2; Cyclooxygenase-2; COX1; Cyclooxygenase-1; mTOR; Mechanistic target of rapamycin; PI3 K; Phosphatidylinositol-3-kinase; PIP3; Phosphatidyl-inositol 3,4,5-triphosphate; ILK; Integrin

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Regulation of AGR2 expression via 3'UTR shortening

Keywords: هدف مکانیکی رپامایسین; 3'UTR; 3' untranslated region; AGR2; Anterior Gradient 2; BRCA1; Breast cancer 1; HPRT1; Hypoxanthine phosphoribosyltransferase 1; mTOR; Mechanistic target of rapamycin; TORC1; protein complex containing at least TOR (target of rapamycin) and Raptor (

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Molecular pathways related to the longevity promotion and cognitive improvement of Cistanche tubulosa in Drosophila

Keywords: هدف مکانیکی رپامایسین; Aging; Cistanche tubulosa; Cognitive behavior; Herb; AMI; age-related memory impairment; mTOR; mechanistic target of rapamycin; H2O2; hydrogen peroxide; OH⋅−; hydroxyl radical; O2⋅−; superoxide anions;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

ROS-AKT-mTOR axis mediates autophagy of human umbilical vein endothelial cells induced by cooking oil fumes-derived fine particulate matters in vitro

Keywords: هدف مکانیکی رپامایسین; PM2.5; Fine particulate matter of < 2.5 µm in aerodynamic diameter; COFs; Cooking oil fumes; LBW; Low birth weight; ROS; Reactive oxygen species; PI3K; Phosphatidylinositol 3-kinase; mTOR; Mechanistic target of rapamycin; HUVECs; Human umbilical vein en

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma

Keywords: هدف مکانیکی رپامایسین; AMPK; AMP-activated kinase; BRAFi; BRAF inhibitor; ERK; extracellular signal-regulated kinase; ERKi; ERK inhibitor; PGC1α; peroxisome proliferator-activated receptor gamma, coactivator 1-α; MEK; MAPK/ERK kinase; MEKi; MEK inhibitor; mTOR; mechanistic ta

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

The Stromal Microenvironment Modulates Mitochondrial Oxidative Phosphorylation in Chronic Lymphocytic Leukemia Cells

Keywords: هدف مکانیکی رپامایسین; BCR; B-cell receptor; CLL; chronic lymphocytic leukemia; ECAR; extracellular acidification rate; ETC; electron transport chain; MM; mitochondrial mass; MOMP; mitochondrial outer membrane potential; MRC; maximum respiration capacity; mtDNA; mitochondrial D

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Resveratrol-induced autophagy is dependent on IP3Rs and on cytosolic Ca2 +

Keywords: هدف مکانیکی رپامایسین; Akt; protein kinase B; AMPK; AMP-activated protein kinase; BAPTA-AM; 1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid acetoxymethyl ester; DMEM; Dulbecco's modified Eagle's medium; EGTA; ethylene glycol tetraacetic acid; ER; endoplasmic reticu

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Functional consequences of chemically-induced β-arrestin binding to chemokine receptors CXCR4 and CCR5 in the absence of ligand stimulation

Keywords: هدف مکانیکی رپامایسین; βArr; β-arrestin; AP2; adaptor protein 2; Dmr A/C; dimer A/C; FKBP12; 12 kDa FK506-binding protein; FRB; FKBP12-rapamycin-binding; GPCR; G protein-coupled receptor; MCF; mean channel fluorescence; mTOR; mechanistic target of rapamycin; p38; p38 mitogen

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

The role of interleukin-17A in the pathogenesis of kidney diseases

Keywords: هدف مکانیکی رپامایسین; Interleukin-17A; inflammation; kidney disease; AHR; aryl hydrocarbon receptor; AKI; acute kidney injury; ANCA; antineutrophil cytoplasmic antibody; APOE; apolipoprotein E; ASC; apoptosis-associated speck-like protein containing a carboxy-terminal CARD; Ct

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy

Keywords: هدف مکانیکی رپامایسین; Cancer-associated fibroblast; Cytokines; Intermediate metabolite; Autophagy; Tumor relapse; Radiation therapy; CAFs; cancer-associated fibroblasts; IGF1/2; insulin-like growth factor 1/2; CXCL12; C-X-C motif chemokine ligand 12; ROS; reactive oxygen speci

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice

Keywords: هدف مکانیکی رپامایسین; 3MA; 3-methyladenine; ACTB; actin, beta; ATG4B; autophagy related 4B cysteine peptidase; GFP; green fluorescent protein; LC3B; microtubule-associated protein light chain 3B; GST; glutathione-S-transferase; mTOR; mechanistic target of rapamycin; p70S6K; ri

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Combination of histidine, lysine, methionine, and leucine promotes β-casein synthesis via the mechanistic target of rapamycin signaling pathway in bovine mammary epithelial cells

Keywords: هدف مکانیکی رپامایسین; bovine mammary epithelial cells; mechanistic target of rapamycin; β-casein; essential amino acid;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

S100A10 Regulates ULK1 Localization to ER-Mitochondria Contact Sites in IFN-γ-Triggered Autophagy

Keywords: هدف مکانیکی رپامایسین; ANXA2; annexin A2; ATG; autophagy-related; BECN1; Beclin 1; CANX; calnexin; CTSS; cathepsin S; ER; endoplasmic reticulum; HMGB1; high mobility group protein B1; HRP; horseradish peroxidase; MTOR; mechanistic target of rapamycin; PI3K; phosphatidylinositol

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Management of Muscle-Invasive Urothelial Cancer and the Emerging Role of Immunotherapy in Advanced Urothelial Cancer

Keywords: هدف مکانیکی رپامایسین; AKT; AKT serine/threonine kinase 1; BCG; bacillus Calmette-Guérin; CTLA4; cytotoxic T-lymphocyte-associated protein 4; EGFR; epidermal growth factor receptor; FDA; Food and Drug Administration; FGFR; fibroblast growth factor receptor; GC; gemcitabine p

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

Functional integration of complex miRNA networks in central and peripheral lesion and axonal regeneration

Keywords: هدف مکانیکی رپامایسین; AAV(s); adeno-associated virus(es); ADAM; a disintegrin and metalloprotease; AGO(2); argonaut (2); AKT; protein kinase B; APC; adenomatous polyposis coli; ASO(s); antisense oligonucleotide(s); ATF3; activating transcription factor 3; BBB; blood brain barr

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

Metabolic roles of poly(ADP-ribose) polymerases

Keywords: هدف مکانیکی رپامایسین; ABCA1; ATP-binding cassette sub-family A member 1; ACACA; acetyl-CoA carboxylase alpha; ACBD3; acyl-CoA binding domain containing 3; ACLY; ATP citrate lyase; ADP; adenosine diphosphate; ADPR; ADP-ribose; AFLD; alcoholic fatty liver disease; AIF; apoptosis

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

The roles of subcellularly located EGFR in autophagy

Keywords: هدف مکانیکی رپامایسین; AMPK; AMP-activated protein kinase; ATG; autophagy-related; BCL2; B-cell lymphoma 2; BCL2L1; BCL2 like 1; BNIP3; BCL2/Adenovirus E1B-binding protein Nip3; CME; clathrin-mediated endocytosis; cytoSTAT3; cytoplasmic STAT3; Dsbs; double strand breaks; ECD; e

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2017 سفارش ترجمه

Methylglyoxal-induced AMPK activation leads to autophagic degradation of thioredoxin 1 and glyoxalase 2 in HT22 nerve cells

Keywords: هدف مکانیکی رپامایسین; ACC; acetyl co-enzyme A carboxylase; AGE; advanced glycation end products; AMPK; 5′ AMP-activated protein kinase; ATG; autophagy related; BAF; bafilomycin; CQ; chloroquine; DMEM; high-glucose Dulbecco's modified Eagle medium; Glo; glyoxalase; GSH; gluta

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Bromodomain-containing protein 2 induces insulin resistance via the mTOR/Akt signaling pathway and an inflammatory response in adipose tissue

Keywords: هدف مکانیکی رپامایسین; ACM; Adipocyte-conditioned medium; BET; Bromodomain and extraterminal; Brd2; Bromodomain-containing protein 2; WT; Wild-type; SWI/SNF; Switch mating type/sucrose non-fermenting; Deptor; DEP domain containing mTOR-interacting protein; mTOR; Mechanistic tar

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

The mTORC2/PKC pathway sustains compensatory insulin secretion of pancreatic β cells in response to metabolic stress

Keywords: هدف مکانیکی رپامایسین; βRicKO; β-cell-specific knockout of Rictor; GIIS; glucose-induced insulin secretion; HFD; high-fat diet; NCD; normal chow diet; mTOR; mechanistic target of rapamycin; mTORC2; mTOR complex 2; PKC; protein kinase C; PMA; phorbol 12-myristate 13-acetate; R

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

Adhesion-induced eosinophil cytolysis requires the receptor-interacting protein kinase 3 (RIPK3)-mixed lineage kinase-like (MLKL) signaling pathway, which is counterregulated by autophagy

Keywords: هدف مکانیکی رپامایسین; Autophagy; eosinophil cytolysis; eosinophilic disease; necrosis; necroptosis; non-apoptotic cell death; mixed lineage kinase-like; RIP kinase; reactive oxygen species; cfeg; Cluster of free eosinophil granules; CR3; Complement receptor 3; DPI; Diphenylene

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2017 سفارش ترجمه

Regulation of autophagy by mitochondrial phospholipids in health and diseases

Keywords: هدف مکانیکی رپامایسین; ALCAT1; lysocardiolipin acyltransferase 1; ALE1; lysophospholipid acyltransferase (yeast); AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATGL; adipose triglyceride lipase; AVT1; amino acid vacuolar transport; BNIP3; BCL2/adenovirus E1B

دانلود رایگان متن کامل مقاله ISI 84 صفحه سال انتشار : 2017 سفارش ترجمه

Gene expression profiling reveals the role of RIG1 like receptor signaling in p53 dependent apoptosis induced by PUVA in keratinocytes

Keywords: هدف مکانیکی رپامایسین; PUVA; 8-methoxypsoralen plus UVA; RIG-1; retinoic acid induced gene 1; MDA5; melanoma differentiation associated gene 5; MAVS; mitochondrial antiviral signaling protein; TBK; TANK-binding kinase 1; IKKε; inhibitor of kappaB kinase epsilon; IRF3; interfer

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Collagen XVII Shedding Suppresses Re-Epithelialization by Directing Keratinocyte Migration and Dampening mTOR Signaling

Keywords: هدف مکانیکی رپامایسین; ADAMs; a disintegrin and metalloproteinases; Akt; acutely transforming retrovirus AKT8 in rodent T-cell lymphoma; ECM; extracellular matrix; HD; hemidesmosome; mTOR; mechanistic target of rapamycin; PI3K; phosphoinositide 3-kinase;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-α-lipoic acid, in human hepatocellular carcinoma cells

Keywords: هدف مکانیکی رپامایسین; ACC; acetyl-CoA carboxylase; Akt; protein kinase B; AMPK; AMP-activated protein kinase; apoB; apolipoprotein B; apoE; apolipoprotein E; CPT1α; carnitine palmitoyltransferase 1α; DGAT1; diacylglycerol O-acyltransferase 1; DGAT2; diacylglycerol O-acyltran

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه