York platelet syndrome is a CRAC channelopathy due to gain-of-function mutations in STIM1
Keywords: STIM1; York Platelet syndrome;
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Homer proteins mediate the interaction between STIM1 and Cav1.2 channels
Keywords: Homer1; STIM1; Cav1.2 channels; Ca2 + entry; Protein–protein interactions; Nifedipine
IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes: A plausible mechanism of IL-9R in atopic dermatitis
Keywords: IL-9; IL-9R; IL-8; STIM1; Keratinocytes; ERK
Facilitation of Orai3 targeting and store-operated function by Orai1
Keywords: Immunological synapse; Clustering; Concatenated channel; CRAC; STIM1; Stoichiometry;
STIM1 phosphorylation triggered by epidermal growth factor mediates cell migration
Keywords: EGF, epidermal growth factor; ER, endoplasmic reticulum; EMT, epithelial–mesenchymal transition; ERK, extracellular signal-regulated kinase; SOCE, store-operated Ca2 + entryCalcium; EGF; ERK1/2; Migration; Phosphorylation; STIM1
Molecular determinants of TRPC1 regulation within ER-PM junctions
Keywords: TRPC; STIM1; Orai1; SOCE; ER-PM junctions; Lipid rafts; Caveolin;
The STIM1-ORAI1 microdomain
Keywords: STIM1; ORAI1; CRAC channel; Store-operated calcium entry; Microdomain; Calcium;
FKBP25 and FKBP38 regulate non-capacitative calcium entry through TRPC6
Keywords: Cyps; cyclophilins; FKBPs; immunophilins; FKBD; FK506-binding domain; ER; rough endoplasmic reticulum; SERCA; sarco-endoplasmic Ca2+-ATPase; IP3Rs; inositol 1,4,5-trisphosphate receptors; IP3; inositol 1,4,5-trisphosphate; TRPC; transient receptor potenti
Original ResearchFull Report: Basic and Translational-PancreasInhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models
Keywords: STIM1; SOCE; Calcium Entry Inhibition; Drug Development; Experimental Pancreatitis; AP; acute pancreatitis; [Ca2+]C; cytosolic calcium concentration; CCK; cholecystokinin; CER; cerulein; FAEE; fatty acid ethyl ester; IC50; half-maximal inhibitory concentr
STIM1 elevation in the heart results in aberrant Ca2Â + handling and cardiomyopathy
Keywords: AngII; angiotensin II; BDM; 2,3-butanedione monoxime; CaMKII; Ca2Â +/calmodulin-dependent protein kinase II; CMF; Ca2Â +- and Mg2Â +-free Ringer's solution; CPA; cyclopiazonic acid; EC; excitation-contraction; ER; endoplasmic reticulum; LTCC; L-type Ca2
Fast endocytic recycling determines TRPC1-STIM1 clustering in ER-PM junctions and plasma membrane function of the channel
Keywords: STIM1; Stromal interaction molecule 1; ER; Endoplasmic reticulum; PM; Plasma membrane; TRPC1; Transient receptor potential canonical 1; Arf6; ADP-ribosylation factor 6; [Ca2Â +]i; cytosolic Ca2Â + concentration; SOCE; Store-operated calcium entry; PIP2; p
Ca2+ signaling in taste bud cells and spontaneous preference for fat: Unresolved roles of CD36 and GPR120
Keywords: Lipids; Taste receptor cells; CD36; GPR120; Stim1; Ca2+ influx factor; Fatty acids; AA; arachidonic acid; [Ca2+]i; free intracellular calcium concentration; CaM; calmodulin; CIF; calcium influx factor; cPLA2; cytosolic phospholipase A2; GL; glossopharynge
Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry
Keywords: AFM; atomic force microscopy; CRAC; Ca2+ release-activated Ca2+ channel; ER; endoplasmic reticulum; HA; hemagglutinin; PM; plasma membrane; PAGE; polyacrylamide gel electrophoresis; STIM; stromal interaction molecule; SOAR; STIM1-Orai1 activating region
TRPC1 is involved in Ca2+ influx and cytotoxicity following Pb2+ exposure in human embryonic kidney cells
Keywords: Pb2+; HEK293 cells; TRPC1; Inductively coupled plasma mass spectrometry (ICP-MS); STIM1;
Orai1 and STIM1 are critical for cell migration and proliferation of clear cell renal cell carcinoma
Keywords: Orai1; STIM1; Store-operated Ca2+ channel; Clear cell renal cell carcinoma; Migration; Proliferation;
Ca2+ signaling and regulation of fluid secretion in salivary gland acinar cells
Keywords: Salivary fluid secretion; Calcium signaling; TRPC1; Orai1; STIM1; IP3R
How ORAI and TRP channels interfere with each other: Interaction models and examples from the immune system and the skin
Keywords: ORAI1; STIM1; TRPC; T lymphocytes; keratinocytes; Melanocytes
Potent functional uncoupling between STIM1 and Orai1 by dimeric 2-aminodiphenyl borinate analogs
Keywords: Calcium; STIM1; STIM2; Orai1; Orai2; Orai3; 2-APB;
Increase in muscarinic stimulation-induced Ca2+ response by adenovirus-mediated Stim1-mKO1 gene transfer to rat submandibular acinar cells in vivo
Keywords: Stim1; Adenovirus; Salivary gland; Acinar cell; Ca2+ release; Ca2+ entry;
The critical role of STIM1-dependent Ca2+ signalling during T-cell development and activation
Keywords: T-cell; Calcium signalling; STIM1; Orai1; PMCA;
Positive feedback control between STIM1 and NFATc3 is required for C2C12 myoblast differentiation
Keywords: Myoblast differentiation; C2C12; NFATc3; STIM1; Orai1; SOCE;
TRPC3 regulates release of brain-derived neurotrophic factor from human airway smooth muscle
Keywords: ASM; airway smooth muscle; BAL; bronchial alveolar lavage; BAPTA; 1,2-bis(o-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid; BDNF; brain-derived neurotrophic factor; NT; neurotrophins; ELISA; enzyme linked immunosorbent assay; GFP; green fluorescent pr
Research ReportHigh expression of STIM1 in the early stages of diffuse axonal injury
Keywords: Traumatic brain injury; Diffuse axonal injury; STIM1; SOCE; Calcium;
The apoptosis of non-small cell lung cancer induced by cisplatin through modulation of STIM1
Keywords: Cisplatin; Non-small cell lung cancer; SOC; STIM1; Calcium; Apoptosis;
Store-operated Ca2Â + entry in proliferating and retinoic acid-differentiated N- and S-type neuroblastoma cells
Keywords: Store-operated Ca2Â + entry; Differentiation; STIM1; Orai1; TRPC1; Neuroblastoma;
STIM1 participates in the contractile rhythmicity of HL-1 cells by moderating T-type Ca2Â + channel activity
Keywords: [Ca2Â +]i; concentration of intracellular free Ca2Â +; AFM; atomic force microscopy; CICR; Ca2Â +-induced Ca2Â + release; CRAC; Ca2Â +-release activated Ca2Â + channel; ICa; Ca2Â + current; ICa,T; T-type Ca2Â + current; L-VDCC; L-type voltage-dependent ca
Transient receptor potential ankyrin-1 (TRPA1) modulates store-operated Ca2Â + entry by regulation of STIM1-Orai1 association
Keywords: TRPA1; STIM1; Orai1; Ca2Â + entry; MEG01 cell; TRP channel;
A relay mechanism between EB1 and APC facilitate STIM1 puncta assembly at endoplasmic reticulum-plasma membrane junctions
Keywords: STIM1; EB1; APC; SOCE; Orai;
Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport
Keywords: WRWAMCTUOQMQBZ-UHFFFAOYSA-N; OXLUMBDAWLIIFM-HTFNGVARSA-N; RBZYYGCLZLVISG-UHFFFAOYSA-N; 2-APB; 2-aminoethyl diphenylborinate; CRAC; Ca2+-release activated current; IP3; inositol 1,4,5-triphosphate; SAR; Structure-activity relationship; SERCA; sarco/endop
Blockade of store-operated Ca2+ entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover
Keywords: Store-operated Ca2+ entry; STIM1; Hepatocellular carcinoma; Focal adhesion turnover; Focal adhesion kinase
Inhibition of STIM1 phosphorylation underlies resveratrol-induced inhibition of store-operated calcium entry
Keywords: Resveratrol [PubChem (CID: 445154)]Resveratrol; Store-operated calcium entry; Calcium signaling; STIM1; ERK1/2; End-binding protein 1
How to make a good egg!
Keywords: Oocyte; Egg; Fertilization; Oocyte maturation; Calcium; Egg-to-embryo transition; Remodeling; IP3 receptor; STIM1; Orai1; PMCA; Endoplasmic reticulum;
Calumin, a Ca2+-binding protein on the endoplasmic reticulum, alters the ion permeability of Ca2+ release-activated Ca2+ (CRAC) channels
Keywords: CRAC channel; Ion selectivity; Orai1; STIM1; Patch-clamp; Ca2+ imaging;
Spatio-temporal aspects, pathways and actions of Ca2+ in surfactant secreting pulmonary alveolar type II pneumocytes
Keywords: Lung; Ca2+; Alveolus; Epithelium; Surfactant; Exocytosis; Secretion; Type II cell; Pneumocyte; Purinergic; Purinoceptor; P2Y2; P2X4; Cell stretch; Mechanotransduction; Air-liquid interface; STIM1; Orai1; Capacitative Ca2+ entry; TRIC B; TRPV2; Actin; FA
Inositol 1,4,5-trisphosphate receptors and pacemaker rhythms
Keywords: 2-APB; aminoethoxydiphenyl borate; CICR; Ca2+-induced Ca2+ release; ET-1; endothelinâ1; GPCR; G-protein coupled receptors; HCN4; the hyperpolarization-activated, cyclic nucleotide-gate cation channels 4; IP3R; inositol 1,4,5-trisphosphate receptor; PLC;
Human Th1 and Th2 lymphocytes are distinguished by calcium flux regulation during the first 10Â min of lymphocyte activation
Keywords: AUC; area under the curve; [Ca2+]cyt; cytoplasmic free calcium concentration; CRAC; calcium release activated calcium channel; ER; endoplasmic reticulum; MCU; mitochondrial calcium uniporter; PBMC; peripheral blood mononuclear cells; PHA; phytohemagglutin
Effects of rapamycin-induced oligomerization of parvalbumin, Stim1 and Orai1 in puncta formation
Keywords: Stim1, stromal interaction molecule 1; SOCE, store-operated calcium entry; Pav, parvalbumin B; FKBP12, 12 kDa FK506- and rapamycin-binding protein; FRB, FKBP-rapamycin binding domainStore-operated calcium entry; Puncta formation; STIM1; Orai1; Parvalbumin
STIM1 tyrosine-phosphorylation is required for STIM1-Orai1 association in human platelets
Keywords: STIM1; Stromal interaction molecule 1; SOCE; operated Ca2+ entry mechanism; SERCA2b; sarco-endoplasmic Ca2+-ATPase isotype 2b; IP3R II; inositol trisphosphate receptor; TRPC; transient receptor potential channel; SKFs; Src family of tyrosine kinases; Btk;
Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells
Keywords: ORAI1/CRACM1; STIM1; Store-operated calcium channel; EGF; Cyclooxygenase-2;
Calcium regulates caveolin-1 expression at the transcriptional level
Keywords: Cacna1; L-type calcium channel alpha-1 subunit (c, etc.); HBSS; Hank's buffered salt solution; NFAT; nuclear factor of activated T-cells; PI; propidium iodide; qPCR; quantitative real-time PCR; RT-PCR; reverse transcriptase-polymerase chain reaction; St
Privileged coupling between Ca2+ entry through plasma membrane store-operated Ca2+ channels and the endoplasmic reticulum Ca2+ pump
Keywords: GFP; green fluorescent protein; YFP; yellow fluorescent protein; ER; endoplasmic reticulum; SERCA; sarco/endoplasmic reticulum Ca2+ ATPase; [Ca2+]C; cytosolic free Ca2+ concentration; [Ca2+]ER; Ca2+ concentration inside ER; [Ca2+]M; Ca2+ concentration ins
STIM1 is required for Ca2+ signaling during mammalian fertilization
Keywords: Ca2+ oscillation; STIM1; Store-operated Ca2+ entry; Embryo development; Swine
Analysis of the expression of microtubule plus-end tracking proteins (+TIPs) during Xenopus laevis embryogenesis
Keywords: Xenopus; Microtubule; +TIP; CLIP1; p150glued; CLASP1; LIS1; STIM1;
Capacitative and non-capacitative signaling complexes in human platelets
Keywords: Orai1; Orai2; Orai3; STIM1; STIM2; TRPC
Role of Trpc channels, Stim1 and Orai1 in PGF2α-induced calcium signaling in NRK fibroblasts
Keywords: SOCE; store-operated calcium entry; ROCE; receptor-operated calcium entry; TRPC; transient receptor potential channels; STIM1; stromal interaction molecule 1; NRK; normal rat kidney; PGF2α; prostaglandin F2α; OAG; 1-oleoyl-2-acetyl-sn-glycerol; BHQ; 25-
STIM1 and Orai1 mediate thrombin-induced Ca2+ influx in rat cortical astrocytes
Keywords: STIM1; Orai1; SOCE; Thrombin; Cortical astrocytes;
Store-independent pathways for cytosolic STIM1 clustering in the regulation of store-operated Ca2+ influx
Keywords: STIM1; 2-Aminoethoxydiphenyl borate; Store-operated Ca2+ channels; Mitochondrial Ca2+ release; ORAI;
Lipid rafts are essential for the regulation of SOCE by plasma membrane resident STIM1 in human platelets
Keywords: STIM1; Orai1; Lipid raft; Platelet; Methyl-β-cyclodextrin; Calcium
Calcium entry via ORAI1 regulates glioblastoma cell proliferation and apoptosis
Keywords: 2-APB; 2-aminoethoxydiphenyl borate; CPA; cyclopiazonic acid; CRAC; Ca2+ release activated Ca2+; DES; Diethylstilbestrol; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; GBM; glioblastoma multiforme; ROCE; receptor-operated calcium entr
Transcriptional mechanisms regulating Ca2+ homeostasis
Keywords: WT1; EGR1; STIM1; SERCA; PMCA; Calcium