
Structure-activity relationship and properties optimization of a series of Quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway
Keywords: Wnt pathway; β-catenin; Small molecule; Structure-activity relationship; Glioblastoma; Fz; Frizzled; LRP; lipoprotein receptor-related protein; ACN; acetonitrile; APC; adenomatous polyposis coli; B/P; brain to plasma ratio; CDI; N,Nâ²-carbonyl-diimida