دانلود مقالات ISI درباره Vhl + ترجمه فارسی

Regulation and biological roles of the multifaceted miRNA-23b (MIR23B)

Keywords: miRNAs; MicroRNAs; C9orf3; Chromosome 9 Open Reading Frame 3; pri-miRNAs; primary miRNA; pre-miRNAs; precursor miRNAs; miRISC; miRNA-induced silencing complex; ECs; endothelial cells; VSMCs; vascular smooth muscle cells; ACTA2; smooth muscle α-actin; MYH

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2018 سفارش ترجمه

Multiple solid pancreatic lesions: Prevalence and features of non-malignancies on dynamic enhanced CT

Keywords: MDCT; multi-detector computed tomography; PNEN; pancreatic neuroendocrine neoplasms; AIP; autoimmune pancreatitis; SCN; serous cystadenoma; PAP; pancreatic arterial phase; PVP; portal venous phase; EP; equilibrium phase; MPD; main pancreatic duct; MEN1; m

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2018 سفارش ترجمه

Effects of anoxia on survival and gene expression in Bactrocera dorsalis

Keywords: HIF; hypoxia inducible factor; bHLH; basic helix-loop-helix; PAS; Per-Arnt-Sim; Hsp; heat shock protein; SOD; superoxide dismutase; HIF-1; hypoxia inducible factor 1; VHL; von Hippel-Lindau; HRE; hypoxia response element; CAT; catalase; POX; peroxidase;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

FLCN: The causative gene for Birt-Hogg-Dubé syndrome

Keywords: AEC; alveolar epithelial type II cell; AKT; protein kinase B; AMPK/Ampk; 5′-AMP activated protein kinase; AMPKα (also AAK-2); AMPKα subunit; ATP; adenosine triphosphate; Bcl-2; B-cell lymphoma 2; BHD; Birt-Hogg-Dubé; BAT; brown adipose tissue; C. ele

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2018 سفارش ترجمه

Current PerspectiveHIF-2alpha: Achilles' heel of pseudohypoxic subtype paraganglioma and other related conditions

Keywords: Hypoxia-inducible factor; Paraganglioma; Renal cell carcinoma; von Hippel-Lindau; Krebs cycle; SDHx; Succinate dehydrogenase complex; FH; Fumarate hydratase; MDH2; Malate dehydrogenase 2; VHL; Von Hippel-Lindau; HIF2A; Hypoxia-inducible factor 2 alpha; PH

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Mutations of candidate tumor suppressor genes at chromosome 3p in intrahepatic cholangiocarcinoma

Keywords: VHL; von Hippel-Lindau tumor suppressor; PPARG; peroxisome proliferator-activated receptor gamma; PLCD1; phospholipase C delta 1; RASSF1; Ras association domain family member 1; BAP1; BRCA1-associated protein 1; HYAC1; hyaluronoglucosaminidase 1; ACY1; am

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Hypoxia-inducing factor (HIF)-1α-derived peptide capable of inducing cancer-reactive cytotoxic T lymphocytes from HLA-A24+ patients with renal cell carcinoma

Keywords: HIFs; hypoxia-inducing factors; RCC; renal cell carcinoma; VHL; von Hippel-Lindau; CTLs; cytotoxic T lymphocytes; mRCC; metastatic renal cell carcinoma; IL; interleukin; IFN; interferon; PD-1; programmed cell death-1; PD-L1; PD-ligand-1; CTLA-4; cytotoxic

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Hypoxia and HIF pathway in cancer and the placenta

Keywords: Oxygen; Hypoxia-inducible factor; Placenta; Trophoblast; Cancer; CCRCC; clear cell renal cell carcinoma; FasL; Fas ligand; FIH; factor inhibiting HIF; FLT1; fms-related tyrosine kinase 1; HIF; hypoxia-inducible factor; HLA; human leukocyte antigen; MHC; m

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Systemic Sunitinib Malate Treatment for Advanced Juxtapapillary Retinal Hemangioblastomas Associated with von Hippel-Lindau Disease

Keywords: CNS; central nervous system; HIFα; hypoxia-inducible factor alpha; OD; right eye; OS; left eye; PDGF; platelet-derived growth factor; pVHL; protein von Hippel-Lindau; RCH; retinal capillary hemangioblastomas; TKI; tyrosine kinase inhibitor; VEGF; vascula

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Deregulated expression of VHL mRNA variants in papillary thyroid cancer

Keywords: Papillary thyroid cancer; VHL; Gene expression; Prognosis; Biomarkers;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Targeted protein degradation by PROTACs

Keywords: AR; Androgen Receptor; IV; intravenous; PROTAC; PROteolysis TArgeting Chimera; SC; subcutaneous; TPD; Targeted Protein Degradation; VHL; Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase; Targeted protein degradation; PROTAC; Undruggable pro

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Detecting circulating tumor DNA in renal cancer: An open challenge

Keywords: Circulating tumor DNA; Clear cell RCC; VHL; Colon cancer; KRAS; Next generation sequencing;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Homology modeling and molecular dynamics simulation of the HIF2α degradation-related HIF2α-VHL complex

Keywords: HIF2α; hypoxia-inducible factor 2α; VHL; Von Hippel-Lindau; pVHL; von Hippel Lindau tumor suppressor protein; CODD; C-terminal oxygen-dependent degradation domain; 3D; three-dimensional; ARNT; aryl hydrocarbon receptor nuclear translocator; HRE; hypox

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Implication of VHL, ERK5, and HIF-1alpha in clear cell renal cell carcinoma: Molecular basis1

Keywords: Clear cell renal cell carcinoma; VHL; Signaling pathway; Biomarkers;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Laser Photocoagulation for Peripheral Retinal Capillary Hemangioblastoma in von Hippel-Lindau Disease

Keywords: DD; disc diameter; FA; fluorescein angiography; RCH; retinal capillary hemangioblastoma; TTT; transpupillary thermotherapy; VHL; von Hippel-Lindau;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents

Keywords: MDR; BCR-ABL inhibitors; EGFR inhibitors; VEGFR inhibitors; Drug combinations; ABC; ATP binding cassette; ADME-tox; absorption, distribution, metabolism, excretion, toxicity; AKT; v-akt murine thymoma viral oncogene homolog; ALL; acute lymphoblastic leuke

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

Hepatic hypoxia-inducible factors inhibit PPARα expression to exacerbate acetaminophen induced oxidative stress and hepatotoxicity

Keywords: ALT; alanine aminotransferase; APAP; acetaminophen; AST; aspartate aminotransferase; CCK8; Cell Counting Kit-8; DAB; 3,3′-diaminobenzidine; DAPI; 4′, 6-diamidino-2-phenylindole; DCFH-DA; 2′,7′-Dichlorofluorescein diacetate; DHE; dihydroethidium; D

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2017 سفارش ترجمه

Wild-type VHL Clear Cell Renal Cell Carcinomas Are a Distinct Clinical and Histologic Entity: A 10-Year Follow-up

Keywords: Clear cell renal carcinoma; Kidney cancer; Pathology; Prognosis; Survival; VHL;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Cullin 5-RING E3 ubiquitin ligases, new therapeutic targets?

Keywords: E3 ubiquitin ligase; Cullin RING ligase; Ubiquitin-proteasome system; Therapeutic targets; ASB; ankyrin repeat-containing proteins with a SOCS box; β-Trcp; β-transducin repeat-containing protein; BTB; bric-a-brac; CIS1; cytokine-inducible Src homology

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

CITED2 controls the hypoxic signaling by snatching p300 from the two distinct activation domains of HIF-1α

Keywords: HIF-1α; hypoxia-inducible factor 1α; CITED2; CBP/p300-interacting transactivator with an ED-rich tail 2; FIH; factor inhibiting HIF; VHL; von Hippel-Lindau; NAD; N-terminal transactivation domain; CAD; C-terminal transactivation domain; CH1/2; Cystein

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Research reportKnockout of programmed cell death 5 (PDCD5) gene attenuates neuron injury after middle cerebral artery occlusion in mice

Keywords: PDCD5; programmed cell death 5; RhPDCD5; recombinant human programmed cell death 5; MCAO; middle cerebral artery occlusion; VHL; von Hippel-Lindau tumor suppressor protein; Mdm2; mouse double minute 2 homolog; HIF-1α; hypoxia-inducible factor 1 alpha; BN

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Reprogramming carcinoma associated fibroblasts by AC1MMYR2 impedes tumor metastasis and improves chemotherapy efficacy

Keywords: AC1MMYR2; Carcinoma associated fibroblasts; NF-кB; VHL; Metastasis

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Non-canonical GLI1/2 activation by PI3K/AKT signaling in renal cell carcinoma: A novel potential therapeutic target

Keywords: Renal cell carcinoma; Hedgehog pathway; VHL; PI3K/AKT; Therapeutic target;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

The lncRNA MALAT1, acting through HIF-1α stabilization, enhances arsenite-induced glycolysis in human hepatic L-02 cells

Keywords: lncRNAs; long non-coding RNAs; MALAT1; metastasis-associated lung adenocarcinoma transcript 1; HIFs; hypoxia inducible factors; VHL; Von Hippel-Lindau; Glut-4; glucose transporter type 4; Eno-1; enolase-1; HK-2; hexokinase-2; PDK-1; pyruvate dehydrogena

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling

Keywords: HIF2α; VHL; hypoxia; glucagon; ERK; PKA; CREB

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Exploring miRNA based approaches in cancer diagnostics and therapeutics

Keywords: miRNA; microRNA; TRBP; Transactivating Response RNA-Binding Protein; RISC; RNA induced silencing complex; UTR; untranslated region; DDX; DEAD box protein; TS; tumor suppressor; OG; oncogene; TGF β; Transforming Growth Factor β; RT-PCR; Real Time-polymer

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Prognostic Value of SETD2 Expression in Patients with Metastatic Renal Cell Carcinoma Treated with Tyrosine Kinase Inhibitors

Keywords: carcinoma; renal cell; neoplasm metastasis; survival; disease-free survival; biomarkers; ccRCC; clear cell renal cell carcinoma; IHC; immunohistochemistry; IRS; immunoreactivity score; mRCC; metastatic renal cell carcinoma; OS; overall survival; PFS; prog

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

Role of RSUME in inflammation and cancer

Keywords: RWD-domain-containing sumoylation enhancer; RWDD3; Hypoxia; VHL; Sumoylation;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

VHL negatively regulates SARS coronavirus replication by modulating nsp16 ubiquitination and stability

Keywords: VHL; SARS-CoV; nsp16; Replication; Ubiquitination;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer

Keywords: DNA damage; Stress response; Treatment failure; Cancer; MYBBP1A; Myb-binding protein 1A; OPSCC; oropharyngeal squamous cell carcinoma; HNSCC; head and neck squamous cell carcinoma; SA-β-Gal; senescence-associated β-galactosidase; SAHF; senescence-associ

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

All-encomPASsing regulation of β-cells: PAS domain proteins in β-cell dysfunction and diabetes

Keywords: PAS domain; β-cells; diabetes; hypoxia; circadian; insulin secretion; Per; Arnt; Sim; Bmal1; Clock; Npas4; Hif1α; Vhl; Pask

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Cellular repressor of E1A-stimulated gene overexpression in bone mesenchymal stem cells protects against rat myocardial infarction

Keywords: BMSCs; CREG; HIF-1α; Myocardial infarction; VHL;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

microRNA-107 functions as a candidate tumor suppressor gene in renal clear cell carcinoma involving multiple genes

Keywords: Renal cell carcinoma; EIF5; p53; VHL; MicroRNA; miR-107;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

MicroRNA-185 inhibits cell proliferation and induces cell apoptosis by targeting VEGFA directly in von Hippel-Lindau-inactivated clear cell renal cell carcinoma

Keywords: VHL; MicroRNA-185; VEGFA; Clear cell renal cell carcinoma; Proliferation; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Targeting strategies on miRNA-21 and PDCD4 for glioblastoma

Keywords: GBM; glioblastoma multiforme; miRNAs; microRNAs; PDCD4; programmed cell death 4; EMT; epithelial-mesenchymal transition; JNK; Jun N-terminal protein kinase; PTEN; phosphatase and tensin homolog; PI3K/AKT; phosphatidylinositol-3 kinase/Akt; MAPK/ERK; mit

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2015 سفارش ترجمه

MicroRNAs as regulatory elements in triple negative breast cancer

Keywords: HER2; human epidermal growth factor receptor 2; RISC; RNA-induced silencing complex; NF-κB; nuclear factor κB; Rb; retinoblastoma; XIAP; X-linked inhibitor of apoptosis; VHL; von Hippel-Lindau; PKCα; protein kinase Cα; TNBC; triple negative breast c

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Hypoxia inducible factor-1α suppresses Peroxiredoxin 3 expression to promote proliferation of CCRCC cells

Keywords: VHL; HIF-1α; Prx3; Proliferation;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Design of a PROTAC that antagonizes and destroys the cancer-forming X-protein of the hepatitis B virus

Keywords: aa; amino acid; CPP; cell-penetrating peptide; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; HIF; hypoxia-inducible factor; ODD; oxygen-dependent degradation; pRb; retinoblastoma protein; PROTAC; proteolysis targeting chimeric molecule; SCF; Skp1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Modulation of Dcytb (Cybrd 1) expression and function by iron, dehydroascorbate and Hif-2α in cultured cells

Keywords: Dcytb; Duodenal cytochrome b; DHA; Dehydroascorbic acid; AA; Ascorbic acid; DFO; Desferrioxamine; Fe-NTA; Ferric-nitrilotriacetate; FAC; Ferric ammonium citrate; HRE; Hypoxia response element; PHDs; Prolyl hydroxylases; VHL; Von-Hippel-Lindau; ARNT; A

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Loss of VHL expression contributes to epithelial–mesenchymal transition in oral squamous cell carcinoma

Keywords: VHL; Oral squamous cell carcinoma; Epithelial–mesenchymal transition; β-Catenin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Carbonic anhydrase inhibitors: Synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties

Keywords: CA; carbonic anhydrase; hCA; human carbonic anhydrase; CAI; carbonic anhydrase inhibitor; SAR; structure-activity relationship; Zn; zinc; AZM; acetazolamide; MZA; methazolamide; EZA; ethoxzolamide; DCP; dibromophenamide; DZA; dorzolamide; BRZ; brinzolam

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

NADPH oxidase-mitochondria axis-derived ROS mediate arsenite-induced HIF-1α stabilization by inhibiting prolyl hydroxylases activity

Keywords: ROS; reactive oxygen species; PHDs; prolyl hydroxylases; HIF-1α; hypoxia inducible factor 1α; VEGF; vascular endothelial growth factor; VHL; von Hippel Lindau; DPI; diphenyleneiodonium chloride; DCFH-DA; 2′,7′-dichlorofluorescein-diacetate; DHE; dih

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

False start: Cotranslational protein ubiquitination and cytosolic protein quality control

Keywords: CHIP; C-terminus of Hsc70-interacting protein; DRiP; defective ribosomal product; ER; endoplasmic reticulum; ERAD; ER-associated protein degradation; NAC; nascent polypeptide-associated complex; NEF; nucleotide exchange factor; NGD; no-go decay; NMD; nons

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Silencing glucose-regulated protein 78 induced renal cell carcinoma cell line G1 cell-cycle arrest and resistance to conventional chemotherapy

Keywords: Grp78; Herp; VHL; UPR; Cell cycle; Chemotherapy;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

The H+-ATP synthase: A gate to ROS-mediated cell death or cell survival

Keywords: AIF; apoptosis inducing factor; Akt; v-Akt murine thymoma viral oncogene; AP-1; activator protein 1; ARE; antioxidant responsive element; ASK1; apoptosis signal-regulated kinase 1; ATM; ataxia telangiectasia mutated; Duox; Dual oxidase enzymes; DUSP3; dua

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Honokiol inhibits pathological retinal neovascularization in oxygen-induced retinopathy mouse model

Keywords: HIF; hypoxia inducible factor; HRE; hypoxia response element; PHD; prolyl hydroxylation domain; VHL; von Hippel-Lindau; VEGF; vascular endothelial growth factor; OIR; oxygen-induced retinopathy; P; postnatal day; IP; intraperitoneal; Hypoxia signaling;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Analysis of the inheritance pattern of a Chinese family with phaeochromocytomas through whole exome sequencing

Keywords: CT; Computed Tomography; CTA; Computed Tomography Angiography; FDR; False Discovery Rate; GO; Gene Ontology; Indel; Insertion-Deletion; LOD; Logarithm of Odds; MEN2; Multiple Endocrine Neoplasia Type 2; MN; Metanephrine; NF1; Neurofibromatosis Type 1; N

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Gambogic acid inhibits angiogenesis through inhibiting PHD2-VHL-HIF-1α pathway

Keywords: GA; Angiogenesis; VEGF; HIF-1α; VHL; PHD2;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Hypoxia mediated expression of stem cell markers in VHL-associated hemangioblastomas

Keywords: VHL; von Hippele-Lindau; HIF; hypoxia-inducible-factor; HRE; hypoxia response element; PHD; prolyl hydroxylation domain; VEGF; vascular endothelial growth factor; EPO; erythropoietin; PDGF; platelet-derived growth factor; JMJD1A; Jmj-domain containing pro

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Tumor suppressor protein VHL inhibits Hedgehog-Gli activation through suppression of Gli1 nuclear localization

Keywords: VHL; Gli; Hedgehog signaling; Tumor suppression;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه