کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10010952 | 1587680 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Psoriasis-recent advances in understanding its pathogenesis and treatment
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کلمات کلیدی
VPFTh1, Th2HEVICAMIBDAPCLFAEGF-RIFN-γantigen-presenting cell - آنتیژن ارائه سلولinterleukin - اینترلوکینInflammatory bowel disease - بیماریهای التهابی رودهtumor necrosis factor alpha - تومور نکروز عامل آلفاvascular permeability factor - عامل نفوذ پذیری عروقیVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)TNF-α - فاکتور نکروز توموری آلفاMHC - مجموعه سازگاری بافتی اصلیmajor histocompatibility complex - مجموعه سازگاری بافتی اصلیintercellular adhesion molecule - مولکول چسبندگی بین سلولیhigh endothelial venule - ونول اندوتلیوم بالاInterferon gamma - گاما اینترفرونEpidermal growth factor receptor - گیرنده فاکتور رشد اپیدرمال
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
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چکیده انگلیسی
Although not completely understood, there is clearly a genetic component in the development of psoriasis. Twin studies show a 67% concordance for monozygotic twins versus 18% for dizygotic twins. This lack of complete concordance in monozygotic twins suggests multifactorial inheritance and interaction between genetic predisposition and the environment. At present, 8 different psoriasis susceptibility loci have been identified in genome-wide linkage scans, including locations on 15 different chromosomes. Genetic connections have been made between psoriasis and other diseases, including atopic dermatitis, rheumatoid arthritis, and Crohn's disease. A variety of approaches are available for the treatment of psoriasis, ranging from topical agents for milder forms of the disease to phototherapy and systemic agents for severe psoriasis. Despite the importance of systemic therapies and recent advances represented by biologic agents, topical treatments will probably remain the mainstay of psoriasis therapy for most patients. The advent of new, cosmetically attractive vehicles may enhance compliance, add to the use of topical agents, and potentially improve patient outcomes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 53, Issue 1, Supplement, July 2005, Pages S94-S100
Journal: Journal of the American Academy of Dermatology - Volume 53, Issue 1, Supplement, July 2005, Pages S94-S100
نویسندگان
Gerald MD, Charles N. MD,