کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162803 | 1114359 | 2012 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and Evaluation of Novel Glass Ceramics as Drug Delivery Systems in Osteomyelitis
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کلمات کلیدی
Tricalcium phosphateHydroxycarbonate apatite - آپاتیت هیدروکسید کربناتOsteomyelitis - استئومیلیتBone substitute - جایگزین استخوانScaffold - داربَستDrug delivery system - سیستم تحویل داروBone infection - عفونت استخوانیMineralization - معدنی سازی یا کانی سازیHydroxyapatite - هیدروکسی آپاتیتVancomycin - وانکومایسین
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
In this study, a new generation of bioactive glass ceramics were developed using the wet chemical method. The synthetic conditions were strictly controlled to obtain the materials of a nanometric scale. As evaluated by scanning electron microscopy, bone-like apatite layers were produced in large amounts and completely covered their surfaces after immersion in phosphate buffer saline. On the basis of X-ray diffraction, X-ray fluorescence, and Fourier transform infrared spectroscopy results, PO43â groups of hydroxyapatite (HA) were partially substituted by SiO44â species. The defective chemical structures introduced provided materials that were more biologically active, compared with the parent HA. For effective treatment of infected bones, scaffolds containing the bioactive ceramics were prepared by chitosan cross-linking, and loaded with vancomycin (VCM). The drug-loaded scaffolds were not toxic to bone cells. About 75%-80% of the entrapped drug was released in a controlled pattern and the release was sustained over a 12-day period. The concentration of drug released was determined to be above 20 times the half maximal effective concentration of VCM on Staphylococcus aureus, and was sufficient for killing bacteria growing as biofilm. In summary, the synthesized bioceramics exhibited many of properties associated with an ideal material for implantable drug delivery system, and were suitable for testing the ability to cure bone diseases including osteomyelitis. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 8, August 2012, Pages 2870-2882
Journal: Journal of Pharmaceutical Sciences - Volume 101, Issue 8, August 2012, Pages 2870-2882
نویسندگان
Suphannee Thanyaphoo, Jasadee Kaewsrichan,