کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10223400 | 1701028 | 2019 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The lagged effects of environmentally relevant zinc on non-specific immunity in zebrafish
ترجمه فارسی عنوان
اثرات ناشی از روی زیست محیطی مربوط به ایمنی غیر اختصاصی در ماهی قزل آلا
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کلمات کلیدی
MDAcopper/zinc-superoxide dismutaseHSF1IL-6P65IL-1βhsp70SGRiNOSNrf2ROS - ROSinterleukin-6 - اینترلوکین ۶Interleukin-1β - اینترلوکین-1βtumor necrosis factor-α - تومور نکروز عامل αinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییNF-E2-related factor 2 - عامل NF-E2 2heat shock factor 1 - عامل شوک گرما 1TNF-α - فاکتور نکروز توموری آلفاZinc - فلز رویmalondialdehyde - مالون دی آلدهیدFish - ماهیImmunity - مصونیتSurvival rate - نرخ بقاspecific growth rate - نرخ رشد خاصheat shock protein 70 - پروتئین شوک حرارت 70Post-exposure - پس از قرار گرفتن در معرضCatalase - کاتالازCadmium - کادمیمReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
چکیده انگلیسی
Responses to zinc (Zn) during exposure have well studied but the effects after the exposure are commonly neglected. In the study, non-specific immune response to zinc in blood and spleen of zebrafish was evaluated after exposure. At first, fish were subjected to 0 (control) and 200â¯Î¼g/L zinc (Zn) for 6 weeks. Specific growth rate, survival rate, blood albumin level, and the activities of Cu/Zn-SOD and iNOS were not significantly changed by Zn exposure. Conversely, Zn increased the levels of globulin and hemoglobin, CAT activity, and mRNA levels of nrf2, sod1, cat, hsf1, hsp70, p65, il-6, il-1β, tnf-α and inos. In the second experiment, zebrafish were transferred to a recovery period for 4 and 8 days. The increased activities of Cu/Zn-SOD and CAT and the up-regulated mRNA levels of nrf2, cat, p65, tnf-α, and inos still were observed. In the third experiment, zebrafish from 4â¯d post-exposure were re-exposed to the high levels of Zn and cadmium (Cd) (600, 1200â¯Î¼g/L Zn; 100, 200â¯Î¼g/L Cd) for 4 days. 100â¯Î¼g/L Cd caused a higher survival rate in the Zn-exposed fish than the control, suggesting Zn pre-exposure might develop the tolerance to Zn and Cd. Although transcriptional levels of sod1, hsf1, hsf2, hsp70, il-6 and il-1β and activity levels of iNOS recovered to the control levels at 4 and 8â¯d post-exposure, differences in magnitude of responsiveness were observed between normal fish and Zn-exposed fish. Overall, Zn acclimation persisted when fish recovered, which provides a new perspective about Zn toxicology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 214, January 2019, Pages 85-93
Journal: Chemosphere - Volume 214, January 2019, Pages 85-93
نویسندگان
Lan-Fang Si, Cheng-Cheng Wang, Sai-Nan Guo, Jia-Lang Zheng, Hu Xia,