کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10451557 | 918467 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transcutaneous electrical nerve stimulation activates peripherally located alpha-2A adrenergic receptors
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کلمات کلیدی
α2ARi.a.ID50nmolμLs.c.ED50intracerebroventriculari.c.v.50% effective dose - 50٪ دوز موثرadrenergic - آدرنرژیکi.t. - آی تی.inflammation - التهاب( توروم) intrathecal - اینتراکتالconfidence limit - حد اعتمادstandard error of the mean - خطای استاندارد میانگینPain - دردTENS - ده هاsubcutaneous - زیر جلدیHour - ساعتSpinal cord - طناب نخاعیNumber - عددSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیIntra-articular - مفصلی داخلJoint - مَفصَل یا بندگاهMicroliter - میکرولیترCarrageenan - کاراگینانGram - گرامα2-adrenergic receptor - گیرنده α2-adrenergic
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The alpha2A and alpha2C adrenergic receptor (AR) subtypes mediate antinociception when activated by the endogenous ligand norepinephrine. These receptors also produce antinociceptive synergy when activated concurrently with opioid receptor activation. The involvement of the opioid receptors in the mechanisms governing transcutaneous electrical nerve stimulation (TENS) has been well described. While spinal alpha-2 ARs do not appear to be involved in TENS antihyperalgesia in rats, the noradrenergic analgesic system also involves supraspinal and peripheral sites. Thus, a broader evaluation of the potential contribution of alpha-2 AR to TENS is warranted. The current study compared the antihyperalgesic efficacy of high (100Â Hz) and low (4Â Hz) frequency TENS in mutant mice lacking a functional alpha2A AR against their respective wildtype counterparts. The degree of secondary heat hyperalgesia induced by intra-articular injection of carrageenan/kaolin (3%) mixture did not differ among the experimental groups. However, the antihyperalgesia induced by both low and high frequency TENS was significantly diminished in alpha2A mutant mice compared to controls. The alpha2 adrenergic receptor selective antagonist, SK&F 86466, reversed TENS-mediated antihyperalgesia when delivered intra-articularly, but not when delivered intrathecally or intracerebroventricularly. These data suggest that peripheral alpha2 ARs contribute, in part, to TENS antihyperalgesia. This pharmacodynamic response is consistent with previous anatomical observations that alpha2A ARs are expressed on primary afferent neurons and macrophages near injured tissue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pain - Volume 115, Issue 3, June 2005, Pages 364-373
Journal: Pain - Volume 115, Issue 3, June 2005, Pages 364-373
نویسندگان
Ellen W. King, Katherine Audette, Gwendolyn A. Athman, H. Oanh X. Nguyen, Kathleen A. Sluka, Carolyn A. Fairbanks,