کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10452234 | 918826 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expressão do VEGF e dos receptores Flt-1 e Flk-1 no corpo cavernoso do rato. Acção do envelhecimento e da orquidectomia
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
عمل جراحی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Immunohistochemical results demonstrated that both VEGF and VEGFR-1 were expressed in smooth muscle fibers, particularly in those surrounding the vascular endothelium, while endothelial expression was very low, especially in control and orchidectomized rats. VEGFR-2 expression was extended to the endothelium in all three groups: control group (2 months old), orchidectomized, and aged animals (12 and 18 months old). In aged rats, a shift resulting in VEGF and VEGFR-1 colocalization in the endothelial cell was observed. Our findings suggest an upregulation of VEGFR-1 in rat corpora cavernosa during aging, with a clear increase in expression by endothelial cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revista Internacional de AndrologÃa - Volume 3, Issue 3, September 2005, Pages 120-127
Journal: Revista Internacional de AndrologÃa - Volume 3, Issue 3, September 2005, Pages 120-127
نویسندگان
J. Santos, D. Neves, N. Tomada, H. Almeida, P. Vendeira,