Modulatory roles of NHERF1 and NHERF2 in cell surface expression of the glutamate transporter GLAST

► NHERF1 and NHERF2 differentially interact with the glutamate transporter, GLAST. ► NHERF1 interacts with GLAST in the ER to facilitate the ER exit of GLAST. ► Transit from NHERF1 to NHERF2 of GLAST occurs in the ERGIC. ► NHERF2 also interacts with GLAST in the plasma membrane and endosomes. ► NHERF1 and NHERF2 modulate the cell surface expression of GLAST.