Oxidized phospholipids impair pulmonary antibacterial defenses: Evidence in mice exposed to cigarette smoke

► Cigarette smoking impair macrophage bacterial phagocytosis but mechanisms unclear. ► Cigarette smoke (CS) exposure increase oxidized phospholipids (Ox-PLs) in mice lungs. ► Instillation of Ox-PLs impair bacterial clearance in mice lungs. ► EO6 mAb prevents Ox-PLs induced inhibition of macrophage bacterial phagocytosis. ► Ox-PLs in lungs of CS-exposed mice impair macrophage bacterial phagocytosis.