Differential effects of miR-34c-3p and miR-34c-5p on SiHa cells proliferation apoptosis, migration and invasion

► In this study we examine miR-34c-3p and miR-34c-5p functions in SiHa cells. ► We study miRNA effect on cell proliferation, anchorage independent growth, apoptosis, cell motility and invasion. ► We find that miR-34c-3p and miR-34c-5p inhibition of proliferation and anchorage independent growth are exclusive to SiHa cells. ► miR-34c-3p induces apoptosis and inhibits cell motility and invasion in SiHa cells. ► In this study we conclude that miR-34c-3p functions as a tumor suppressor differ from miR-34c-5p.