Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice

► AS1535907 represents a novel small-molecule GPR119 agonist that enhances insulin secretion at 16.8 mM glucose in rat islets. ► AS1535907 enhances the first phase of insulin secretion at 16.8 mM glucose in isolated perfused rat pancreas. ► AS1535907 reduces blood glucose levels due to the rapid secretion on insulin secretion following oral glucose loading in diabetic db/db mice.