Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells

► 12(S)-LOX is up-regulated in inflammatory areas of colorectal tumours. ► 12(S)-HETE and 12(S)-LOX over-expression stimulate malignant growth and migration. ► 12(S)-LOX over-expressing SW480 cells have a higher tendency to metastasise. ► Blocking 12(S)-LOX activity or expression inhibits malignant growth and migration.