کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10962574 1102641 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Advancing a vaccine to prevent hookworm disease and anemia
ترجمه فارسی عنوان
پیشگیری از واکسن برای جلوگیری از بیماری قلبی و کم خونی
کلمات کلیدی
کرم هوک، واکسن، ناکتور بیماری های گرمسیری نادیده گرفته شده،
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی
A human hookworm vaccine is under development and in clinical trials in Africa and the Americas. The vaccine contains the Na-APR-1 and Na-GST-1 antigens. It elicits neutralizing antibodies that interfere with establishment of the adult hookworm in the gut and the ability of the parasite to feed on blood. The vaccine target product profile is focused on the immunization of children to prevent hookworm infection and anemia caused by Necator americanus. It is intended for use in low- and middle-income countries where hookworm is highly endemic and responsible for at least three million disability-adjusted life years. So far, the human hookworm vaccine is being developed in the non-profit sector through the Sabin Vaccine Institute Product Development Partnership (PDP), in collaboration with the HOOKVAC consortium of European and African partners. We envision the vaccine to be incorporated into health systems as part of an elimination strategy for hookworm infection and other neglected tropical diseases, and as a means to reduce global poverty and address the Sustainable Development Goals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 34, Issue 26, 3 June 2016, Pages 3001-3005
نویسندگان
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