Cost-effectiveness and economic benefits of vaccines in low- and middle-income countries: A systematic review

► Reviews the economic benefits of adult and childhood vaccines in developing countries. ► Identified 108 articles from 51 countries covering 23 vaccines. ► 44 articles reported cost per disability-adjusted life years (DALY) averted. ► Vaccines cost less than $100 ($500) per DALY averted in 52% (77%) of articles. ► Few studies measure the long-term and societal economic benefits from vaccination.