Applications of capillary electrophoresis with chemiluminescence detection in clinical, environmental and food analysis. A review

• An up-to-date critical review about the evolution of CE-CL is presented.
• Tris(2,2ʹ-bipyridine)ruthenium(II) and luminol as the most used CL systems.
• Instrumental designs and strategies for improving resolution and sensitivity.
• Applications in clinical, pharmaceutical, environmental and food analysis.

This paper reviews the latest developments and analytical applications of chemiluminescence detection coupled to capillary electrophoresis (CE-CL). Different sections considering the most common CL systems have been included, such as the tris(2,2ʹ-bipyridine)ruthenium(II) system, the luminol and acridinium derivative reactions, the peroxyoxalate CL or direct oxidations. Improvements in instrumental designs, new strategies for improving both resolution and sensitivity, and applications in different fields such as clinical, pharmaceutical, environmental and food analysis have been included. This review covers the literature from 2010 to 2015.

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