کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1221884 1494649 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Liquid chromatography–tandem mass spectrometry method as the golden standard for therapeutic drug monitoring in renal transplant
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Liquid chromatography–tandem mass spectrometry method as the golden standard for therapeutic drug monitoring in renal transplant
چکیده انگلیسی


• We addressed therapeutic monitoring of immunosuppressants in kidney transplantation.
• Debate on which technology is the golden standard is still open.
• Two technologies for monitoring immunosuppression in kidney transplant patients.
• Effective immunosuppressive therapies by liquid chromatography–mass spectrometry.

Kidney transplanted patients need immunosuppressant therapies. Therapeutic drug monitoring approaches produce the optimal clinical outcome is still under debate. This review details strength and limits of methods available: immunoassay and chromatography-based. Liquid chromatography with mass spectrometry detection is a major breakthrough in therapeutic drug monitoring of immunosuppressive agents and is considered as the method of choice in therapeutic drug monitoring (TDM) of immunosuppressants. Despite the initial high cost for the instrumentation, HPLC–MS is more cost effective than microparticle enzyme immunoassay.The main important features of LC–MS/MS methodology for immunosuppressive drugs are the shortened analysis time, an increased throughput, higher selectivity, specificity, and sensitivity, and low cost of analysis.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 86, December 2013, Pages 123–126
نویسندگان
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