کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1676529 | 1518101 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular dynamics study on the conformational transition of prion induced by the point mutation: F198S
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
فناوری نانو (نانو تکنولوژی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Molecular dynamics study on the conformational transition of prion induced by the point mutation: F198S Molecular dynamics study on the conformational transition of prion induced by the point mutation: F198S](/preview/png/1676529.png)
چکیده انگلیسی
The single point mutation F198S in prion protein can induce aberrant 3-dimensional structure which finally lead to serious disease. One of the most significant differences between normal and abnormal structures is the concentration of α-helix and β-sheet. By employing molecular dynamics method, we studied the structural transition induced by the mutation F198S. Our results show that the loss of the hydrophobic interactions between the 198-th residue and its surroundings may lead to the transition. A creation of additional β-sheet is captured in our investigation which has not been reported in the dynamical studies of mutated induced structure conversion in prion protein.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thin Solid Films - Volume 499, Issues 1â2, 21 March 2006, Pages 224-228
Journal: Thin Solid Films - Volume 499, Issues 1â2, 21 March 2006, Pages 224-228
نویسندگان
Yong Zhang, Luru Dai, Mitsumasa Iwamoto, Zhong-can Ou-Yang,