Investigating regeneration and functional integration of CNS neurons: Lessons from zebrafish genetics and other fish species

► We review the robust innate regenerative potential of the zebrafish CNS. ► Radial glia have been identified as a major source of CNS stem cells. ► We examine the molecular pathways activated during regenerative processes. ► Innovative cell lesioning paradigms that induce regeneration are described. ► Emerging genetic and physiology tools recommend zebrafish for CNS regeneration studies.