کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1905817 | 1534742 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The nature of the cell cycle in neurons: Focus on a “non-canonical” pathway of DNA replication causally related to death
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The nature of the cell cycle in neurons: Focus on a “non-canonical” pathway of DNA replication causally related to death The nature of the cell cycle in neurons: Focus on a “non-canonical” pathway of DNA replication causally related to death](/preview/png/1905817.png)
چکیده انگلیسی
The mechanism whereby a reactivation of cell cycle in neurons causes cell death is beginning to be identified. In cellular models of Alzheimer's disease, activation of a non-canonical pathway of DNA replication contributes to neuronal death. This pathway involves the repair enzyme DNA polymerase-β, which is highly expressed in neurons of the Alzheimer's brain at early stages of the disease. Loading of DNA polymerase-β into the replication forks generates a death signal, which involves the tumor suppressor p53. The increasing knowledge of the main actors of the unscheduled DNA replication in neurons will pave the way for novel therapeutic interventions in Alzheimer's disease and other neurodegenerative disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1772, Issue 4, April 2007, Pages 409–412
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1772, Issue 4, April 2007, Pages 409–412
نویسندگان
Agata Copani, Filippo Caraci, Jeroen J.M. Hoozemans, Marco Calafiore, Maria Angela Sortino, Ferdinando Nicoletti,