کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1936921 1050705 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel neurotrophic effects of sphingosylphosphorylcholine in cerebellar granule neurons and in PC12 cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Novel neurotrophic effects of sphingosylphosphorylcholine in cerebellar granule neurons and in PC12 cells
چکیده انگلیسی

Sphingosylphosphorylcholine (SPC) is a choline-containing naturally occurring derivative of sphingolipid involved in various biological processes. Here we show that SPC displays neurotrophic effects in cerebellar granule neurons (CGNs) and in PC12 cells. When CGNs were cultured under non-depolarizing condition, they exhibited condensed and fragmented nuclei typical of apoptotic phenotype. SPC added to the culture medium rescued cells from undergoing apoptosis. The anti-apoptotic effect of SPC was dependent on the presence of extracellular Ca2+, suggesting that Ca2+ influx occurs upon SPC treatment. In PC12 cells, SPC displayed nerve growth factor-like neuritogenic effect which was sensitive to the presence of Ca2+ channel blocker and Ca2+ withdrawal from the medium. These results suggest that SPC plays novel neurotrophic effects in the nervous system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 364, Issue 1, 7 December 2007, Pages 163–168
نویسندگان
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