کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2403303 | 1102894 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The NKT cell ligand αgalactosylceramide suppresses allergic airway inflammation by induction of a Th1 response The NKT cell ligand αgalactosylceramide suppresses allergic airway inflammation by induction of a Th1 response](/preview/png/2403303.png)
One experimental approach for the treatment of allergic reactions is the stimulation of immunoregulatory NKT cells with the synthetic glycolipid αgalactosylceramide. For a first evaluation of the immunomodulatory potential of αGalCerMPEG a human in vitro allergy model was exploited. Acting as an adjuvant, the glycolipid induced an enhanced Th1-biased allergen-specific immune response of autologous lymphocytes. In a mouse model of allergic airway inflammation, αGalCerMPEG-activated NKT cells promoted a cytokine environment in the spleen, leading to priming of Th1 cells. The shift towards a Th1-dominated allergen-specific immune response thus might mediate the abrogation of allergic airway inflammation and thereby might provide a valid option for therapeutic intervention.
Journal: Vaccine - Volume 29, Issue 25, 6 June 2011, Pages 4249–4255