کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2407301 1103120 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SOCS1 downregulation in dendritic cells promotes memory T-cell responses
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
SOCS1 downregulation in dendritic cells promotes memory T-cell responses
چکیده انگلیسی

SummarySOCS1-1 is crucial for control of immune cell cytokine expression, including those cytokines known to enable memory T-cell formation and homeostasis. In this study, we found that immunization with SOCS1-downregulated bone marrow-derived dendritic cells generated increased antigen-specific CD8+ T memory cells and antigen-specific responses, as measured by ELISPOT, CTL assays, serum ELISAs, and T-cell proliferation assays. Bone marrow-derived dendritic cells in which SOCS1 was downregulated expressed increased levels of surface IL-15Ra and thymic leukemia (TL) antigen, both of which support memory cell development. This work supports a crucial role for SOCS1 in regulation of dendritic cell-directed generation of memory T-cell responses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 26, Issue 8, 20 February 2008, Pages 1128–1135
نویسندگان
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