کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2502566 1557388 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Caprolactam-silica network, a strong potentiator of the antimicrobial activity of kanamycin against Gram-positive and Gram-negative bacterial strains
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Caprolactam-silica network, a strong potentiator of the antimicrobial activity of kanamycin against Gram-positive and Gram-negative bacterial strains
چکیده انگلیسی

Here, we report the fabrication of a novel ɛ-caprolactam-silica (ɛ-SiO2) network and assessed its biocompatibility and ability to improve the antimicrobial activity of kanamycin. The results of the quantitative antimicrobial assay demonstrate that the obtained ɛ-SiO2 network has efficiently improved the kanamycin activity on Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 strains, with a significant decrease of the minimum inhibitory concentration. The ɛ-SiO2 network could be feasibly obtained and represents an alternative for the design of new antibiotic drug carriers or delivery systems to control bacterial infections.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 446, Issues 1–2, 25 March 2013, Pages 63–69
نویسندگان
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