کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2504788 | 1557468 | 2009 | 7 صفحه PDF | دانلود رایگان |
Investigation of the use of solution NMR spectroscopy to determine the effect of organic solvents on chemical shift changes in bases on addition of acids is reported. This information can be useful in the evaluation of solvents and counterion selection for salt formation. 1H and 15N chemical shift changes in three bases (pyrazine, phthalazine, and pyridine) on the addition of acids (1:1 ratio) were determined in various solvents. The effect of acid strength on chemical shift changes was examined. 1H and 15N chemical shift changes indicated protonation (salt formation). The media used affected the observed chemical shift changes. In D2O the data followed the ΔpKa (base–acid) general rule, that the pKa value of the acids should be 2 units lower than the pKa of the base to ensure proton transfer. Protonation, as measured by chemical shift changes using solution NMR spectroscopy, provided novel insight on potential salt formation in different media. Solution NMR spectroscopy appears to be a useful tool to evaluate counter ion and solvent selection for salt formation reaction.
Journal: International Journal of Pharmaceutics - Volume 377, Issues 1–2, 30 July 2009, Pages 105–111