کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2550632 | 1560579 | 2016 | 17 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Tip110: Physical properties, primary structure, and biological functions Tip110: Physical properties, primary structure, and biological functions](/preview/png/2550632.png)
HIV-1 Tat-interacting protein of 110 kDa (Tip110), also referred to as squamous cell carcinoma antigen recognized by T cells 3 (Sart3), p110 or p110nrb, was initially identified as a cDNA clone (KIAA0156) without annotated functions. Over the past twenty years, several functions have been attributed to this protein. The proposed biological functions include roles for Tip110 in pre-mRNA splicing, gene transcription, stem cell biology, and development. Dysregulation of Tip110 is also a contributing factor in the development of cancer and other human diseases. It is clear that our understanding of this protein is rapidly evolving. In this review, we aimed to provide a summary of all the existing literature on this gene/protein and its proposed biological functions.
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Journal: Life Sciences - Volume 149, 15 March 2016, Pages 79–95